Objective To understand the research progress of related biomarkers in early diagnosis of gastric cancer in recent years.Method The domestic and foregin literatures on studies of biomarkers of early diagnosis of gastric cancer in recent years were reviewed.Results At present, the sensitivity and specificity of serum tumor biomarkers of gastric cancer such as CEA and CA19-9 were lower, so the molecular markers that could predict, screen, and diagnose gastric cancer in the early stage were further explored. The recent studies suggested that microRNAs, long non-coding RNAs, circular RNAs, exosome, etc. molecular markers in early diagnosis of gastric cancer had better prospects of clinilal application.Conclusion With the continuous development of molecular biology technology, the values of microRNAs, long non-coding RNAs, circular RNAs, DNA, etc. in early diagnosis of gastric cancer would be further explored.
LÜ Haibing, DAI Zhicheng, ZOU Xiaoming. Recent advances of related biomarkers in early diagnosis of gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(8): 1108-1113. doi: 10.7507/1007-9424.202010116