• Department of Liver Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, P. R. China;
MA Yong, Email: doctormy80@163.com
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Objective To summarize the research advances of pyroptosis in hepatic ischamia reperfusion injury (IRI).Method The literatures about the studies of mechanism of pyroptosis in hepatic IRI were retrieved and analyzed.Results Pyroptosis, also known as inflammatory necrocytosis, was proven to play an important role in hepatic IRI. After sensing stimuli, macrophages in liver activate caspase-1-dependent canonical pathway and caspase-11-dependent non-canonical pathway of pyroptosis, leading to the activation of gasdermin D, release of proinflammatory factors such as interleukin-1β, interleukin-18, etc., and the recruitment of neutrophils. Consequently, pyroptosis caused a more severe hepatic inflammation and aggravated existing cellular injury and dysfunction of liver in hepatic IRI.Conclusions Pyroptosis plays an important roles in liver IRI. Further researches are needed for the prevention and treatment of the related diseases.