Clinical Efficacy of Zoledronic Acid on Postmenopausal Osteoporosis_West China Medical Journal

Authors：

 LILi , WUXU-yi ,  CHENMao-jun

Department of Neurological Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

CHENMao-jun, Email: sjwkhl@163.com

Keywords：

Zoledronic acid; Osteoporosis; Bone mineral density; Nursing

DOI：

10.7507/1002-0179.20140699

Video：

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Objective To observe the treatment effects of zoledronic acid on postmenopausal osteoporosis. Methods Seventy-two postmenopausal osteoporosis patients from July 2007 to December 2010 were randomly divided into observation group and control group, with 36 patients in each. Traditional drug treatment was used in the control group, while traditional drug treatment and zoledronic acid were used for patients in the observation group. The Indicator of bone mineral density (BMD) and ostocalcin were used to comapre the treatment effects between the two groups after one-year treatment. Results There was a significant difference in BMD and osteocalcin in both the observation group and the control group before and after treatment (P<0.05). The treatment effect is superior in the observation group (P<0.05). Conclusion Zoledronic acid is an effective treatment for postmenopausal osteoporosis; it can increase BMD and osteocalcin more effectively.

Citation： LILi, WUXU-yi, CHENMao-jun. Clinical Efficacy of Zoledronic Acid on Postmenopausal Osteoporosis. West China Medical Journal, 2014, 29(12): 2312-2314. doi: 10.7507/1002-0179.20140699 Copy

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1. 卢化爱. 绝经后骨质疏松发病率调查与预防[J]. 中国妇幼保健, 2007, 22(21):3033-3034.
2. Doggrell SA. Recent important clinical trials of drugs in osteoporosis[J]. Expert Opin Pharmacother, 2004, 5(7):1635-1638.
3. 中国健康促进基金会骨质疏松防治中国白皮书委员会. 骨质疏松症中国白皮书[J]. 中华健康管理学杂志, 2009, 6(3):148-154.
4. 刘忠厚, 朱汉民, 杨定焯. 中国人骨质疏松症建议诊断标准(第二稿)[J]. 中国骨质疏松杂志, 2000, 6(1):4-6.
5. 叶初阳, 瞿嵘, 刘延媛, 等. 唑来磷酸联合普伐他汀治疗绝经后妇女骨质疏松[J]. 中国现代药物应用, 2010, 4(14):18-19.
6. 张兆川, 鹿均先, 熊传芝. 锶盐在治疗骨质疏松症中的作用[J]. 现代医学, 2007, 35(1):64-66.
7. 赵利民, 赵维彪, 李毅, 等. 密固达治疗绝经后骨质疏松症的临床观察[J]. 航空航天医学杂志, 2013, 24(6):714-715.
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9. 崔巍, 彭六保. 唑来膦酸的临床应用研究进展[J]. 中南药学, 2006, 4(6):467-469.
10. 赵伟业, 董碧蓉, 欧雪梅, 等. 骨质疏松药物治疗的新进展及循证证据[J]. 中国骨质疏松杂志, 2003, 9(1):80-82, 50.
11. 黄志勇, 谭志明, 庄宇. 唑来膦酸钠治疗骨质疏松症的效果评价(附60例)[J]. 航空航天医药, 2010, 21(8):1333-1334.
12. 周丕琪, 沈霖, 杨艳萍, 等. 密固达治疗骨质疏松症患者的临床观察[J]. 中国中医骨伤科杂志, 2011, 19(6):36-37.
13. 旷鹂, 周萍, 梅艳丽. 静脉注射密固达的不良反应观察和临床护理体会[J]. 中国中医骨伤科杂志, 2011, 19(12):63-64.
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West China Medical Journal

Clinical Efficacy of Zoledronic Acid on Postmenopausal Osteoporosis

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