Cross-sectional Study on the Relationship between Syndromes of Traditional Chinese Medicine and Lung Function in Patients with Chronic Obstructive Pulmonary Disease at Stable Phase_West China Medical Journal

Authors：

 QUBo , ZHOUWei ,  MAOBing

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

MAOBing, Email: maobing2013@yeah.net

Keywords：

Chronic obstructive pulmonary disease; Stable phase; Syndrome of traditional Chinese medicine; Lung function

DOI：

10.7507/1002-0179.20150533

Video：

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Objective ?To investigate the relationship between syndromes of traditional Chinese medicine (TCM) and lung function in patients with chronic obstructive pulmonary disease (COPD) at stable phase. Methods Based on diagnostic criterion of TCM, five groups of symptoms of TCM about stable COPD were established including lung Qi deficiency, lung and spleen Qi deficiency, lung and kidney Qi deficiency, lung Spleen Kidney Qi deficiency, and deficiency of both Qi and Yin. A total of 300 cases which were up to the standard were differentiated into 5 groups by the symptoms. Some basic details and lung function of the patients were recorded, and then statistical analysis was performed to analyze the differences of lung function among groups. Results Forced expiratory volume in the first second in descending order was lung Qi deficiency group, lung and spleen Qi deficiency group, lung and kidney Qi deficiency group, and lung spleen kidney Qi deficiency group (P<0.05). Conclusion These findings suggest that with the progressing of COPD, the symptom type of TCM for COPD patients at stable phase may vary from lung Qi deficiency to lung and spleen Qi deficiency, or to lung and kidney Qi deficiency, and even lung, spleen and kidney Qi deficiency. Lung function tests help reveal substance and pathogenesis of TCM syndromes of patients with stable COPD, and provide evidence for the clinical syndrome.

Citation： QUBo, ZHOUWei, MAOBing. Cross-sectional Study on the Relationship between Syndromes of Traditional Chinese Medicine and Lung Function in Patients with Chronic Obstructive Pulmonary Disease at Stable Phase. West China Medical Journal, 2015, 30(10): 1853-1856. doi: 10.7507/1002-0179.20150533 Copy

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16.	马惠杰, 杨文杰, 陶家驹. ECT肺通气血流显像及肺功能检查在缓解期COPD中西医结合诊断分型中的应用研究[J]. 河北中医, 2004, 26(5):337-338.
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1. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2007年修订版)[J]. 中华内科杂志, 2007, 30(3): 254-261.
2. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (updated 2015)[EB/OL]. (2015-04-02)[2015-04-06]. http://www.goldcopd.org/uploads/users/files/GOLD_Report_2015_Apr2.pdf.
3. 刘建, 刘忠义, 赵文鹏, 等. 中药治疗慢性阻塞性肺疾病稳定期浅析[J]. 河北中医, 2011, 33(2):224.
4. 刘羽雄. 慢性阻塞性肺疾病稳定期中医干预疗效评价结构的分析[D]. 广州:广州中医药大学, 2011.
5. 郑筱萸. 中药新药临床研究指导原则[M]. 北京:中国医药科技出版社, 2002:53-66.
6. 沈自尹. 中医虚证辨证参考标准[J]. 中西医结合杂志, 1983, 6(2): 117.
7. 谭光波, 柏正平, 胡学军. 冬病夏治敷贴疗法对COPD稳定期患者生活质量的影响[C]//第十次全国中西医结合防治呼吸系统疾病学术研讨会论文集. 杭州:中国中西医结合学会, 2009:77-80.
8. 卓宋明, 徐文莉, 梁珊瑚, 等. 慢性阻塞性肺疾病患者T 淋巴细胞亚群凋亡与Fas、FasL、Bcl-2表达的关系[J]. 中华临床医师杂志: 电子版, 2011, 5(6):1554-1560.
9. 陈明静, 吴维平. COPD中医病因病机及辨证分型研究进展[J]. 光明中医, 2009, 24(1):168-169.
10. 吴启相. 慢性阻塞性肺疾病的中医辨治体会[J]. 中国中医急症, 2011, 20(8):1358-1359.
11. 徐雯洁, 王天芳, 王智瑜, 等. 基于现代文献的慢性阻塞性肺疾病中医证候及证候要素的研究[J]. 中华中医药杂志, 2008, 23(1):19-22.
12. 吴蕾, 林琳, 许银姬, 等. 慢性阻塞性肺疾病证候规律中的五脏关系探讨[J]. 新中医, 2010, 42(6):84-85.
13. 尹宝伶. COPD筛查问卷与肺功能检查诊断COPD的相关性研究[D]. 北京:北京中医药大学, 2013.
14. 麻丽丽. 慢性阻塞性肺疾病中医证型与肺功能、生活质量的相关性研究[D]. 太原:山西中医学院, 2013.
15. 陈瑾. COPD患者中医辨证分型与有关指标相关性分析[J]. 辽宁中医药大学学报, 2006, 8(4):7-8.
16. 马惠杰, 杨文杰, 陶家驹. ECT肺通气血流显像及肺功能检查在缓解期COPD中西医结合诊断分型中的应用研究[J]. 河北中医, 2004, 26(5):337-338.
17. 左萍. 补肺益肾丸对COPD稳定期患者呼吸功能的影响[J]. 中国中医药科技, 2010, 17(3):258-259.

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West China Medical Journal

Cross-sectional Study on the Relationship between Syndromes of Traditional Chinese Medicine and Lung Function in Patients with Chronic Obstructive Pulmonary Disease at Stable Phase

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