Effect of smoking on pulmonary function of male patients with chronic obstructive pulmonary disease and their correlation_West China Medical Journal

Authors：

 NIE Xiaohong , JIANG Chuan , LI Xuemei

Department of Respiratory Medicine, 416 Hospital of Nuclear Industry, Chengdu, Sichuan 610051, P. R. China;

Corresponding author：

NIE Xiaohong, Email: xhnie1226@sina.com

Keywords：

Smoking; Chronic obstructive pulmonary disease; Pulmonary function; Correlation analysis

DOI：

10.7507/1002-0179.201602114

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the effect of smoking on pulmonary function parameters of male patients with chronic obstructive pulmonary disease (COPD) and to analyze the correlation between smoking and pulmonary function parameters. Methods From January 2014 to October 2015, the pulmonary function parameters of 223 male outpatients or hospitalized patients with COPD in the Department of Respiratory Medicine were retrospectively analyzed by using SPSS 17.0 software. The patients were randomly divided into smoking group (n=98), smoking cessation group (n=82) and non-smoking group (n=43). Results Various degrees of damage or abnormality of lung capacity, ventilatory function, gas exchange function and airway resistance (Raw) existed in the patients with COPD. Compared with smoking cessation group and non-smoking group, residual volume/ total lung capacity (RV/TLC) and Raw were significantly higher (P< 0.05), maximum ventilatory volume, ventilation reserve percent, forced vital capacity, the percent of first second forced expiratory volume compared its predicted value (FEV₁%pred), maximum mid-expiratory flow (MMEF), forced expiratory flow 50%, forced expiratory flow 75% and diffusing capacity of carbon monoxide were significantly lower (P<0.05) in the smoking group. There was a negative relationship between MMEF, FEV₁%pred and smoking index (r=–0.352, –0.381, P<0.05), and a positive relationship between Raw, RV/TLC and smoking index (r=0.403, 0.378, P<0.05). Conclusions Most of the male COPD patients smoke or used to smoke. Smoking leads to ventilation and gas exchange function decrease, small airway limitation aggravation, airway resistance and emphysema degree increase in COPD patients. Smoking index has a negative relationship with MMEF, FEV₁%pred and a positive relationship with Raw and RV/TLC.

Citation： NIE Xiaohong, JIANG Chuan, LI Xuemei. Effect of smoking on pulmonary function of male patients with chronic obstructive pulmonary disease and their correlation. West China Medical Journal, 2017, 32(6): 852-856. doi: 10.7507/1002-0179.201602114 Copy

1.	Vozoris NT, Stanbrook MB. Smoking prevalence, behaviours, and cessation among individuals with COPD or asthma. Respir Med, 2011, 105(3): 477-484.
2.	兰丰铃, 王胜锋, 曹卫华, 等. 慢性阻塞性肺疾病危险因素流行病学研究新进展. 中华疾病控制杂志, 2014, 18(10): 998-1002.
3.	中华医学会呼吸病学会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南 (2013 年修订版). 中华结核和呼吸杂志, 2013, 36(4): 255-264.
4.	陈明勇, 刘小英, 吴友茹, 等. 远程医学干预对慢性阻塞性肺疾病稳定期患者慢性阻塞性肺疾病评估测试评分的影响. 华西医学, 2014, 29(10): 1807-1809.
5.	Miller MR. Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax, 2014, 69(12): 1145-1146.
6.	Zuo L, He F, Sergakis GG, et al. Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments. Am J Physiol Lung Cell Mol Physiol, 2014, 307(3): L205-L218.
7.	Sears MR. Smoking, asthma, chronic airflow obstruction and COPD. Eur Respir J, 2015, 45(3): 586-588.
8.	李晓茹, 赵子军. 吸烟与慢性阻塞性肺疾病相关性的研究进展. 中国慢性病预防与控制, 2014, 22(1): 110-112.
9.	雒志明, 马丽娜, 聂秀红, 等. 吸烟对 COPD 患者肺功能的影响. 临床肺科杂志, 2011, 16(8): 1250-1251.
10.	陈勃江, 李为民, 袁玉茹. 吸烟对无呼吸道症状个体肺功能的影响. 中华肺部疾病杂志: 电子版, 2011, 4(6): 483-486.
11.	王晓如, 孔庆华, 范颖, 等. 吸烟与老年慢性阻塞性肺疾病患者肺功能受损程度相关性分析. 中国临床医学, 2011, 18(6): 794-796.
12.	Melzer AC, Feemster LC, Crothers K, et al. Respiratory and bronchitic symptoms predict intention to quit smoking among current smokers with, and at risk for, chronic obstructive pulmonary disease. Ann Am Thorac Soc, 2016, 13(9): 1490-1496.
13.	罗勤利. 戒烟干预对不同风险程度慢性阻塞性肺疾病患者预后的影响对比. 临床肺科杂志, 2015, 20(6): 1076-1079.
14.	王聪颖, 张庆, 王少飞, 等. 不同风险慢性阻塞性肺疾病患者戒烟干预后临床症状及肺功能变化研究. 中国全科医学, 2014, 17(1): 50-52.

1. Vozoris NT, Stanbrook MB. Smoking prevalence, behaviours, and cessation among individuals with COPD or asthma. Respir Med, 2011, 105(3): 477-484.
2. 兰丰铃, 王胜锋, 曹卫华, 等. 慢性阻塞性肺疾病危险因素流行病学研究新进展. 中华疾病控制杂志, 2014, 18(10): 998-1002.
3. 中华医学会呼吸病学会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南 (2013 年修订版). 中华结核和呼吸杂志, 2013, 36(4): 255-264.
4. 陈明勇, 刘小英, 吴友茹, 等. 远程医学干预对慢性阻塞性肺疾病稳定期患者慢性阻塞性肺疾病评估测试评分的影响. 华西医学, 2014, 29(10): 1807-1809.
5. Miller MR. Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax, 2014, 69(12): 1145-1146.
6. Zuo L, He F, Sergakis GG, et al. Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments. Am J Physiol Lung Cell Mol Physiol, 2014, 307(3): L205-L218.
7. Sears MR. Smoking, asthma, chronic airflow obstruction and COPD. Eur Respir J, 2015, 45(3): 586-588.
8. 李晓茹, 赵子军. 吸烟与慢性阻塞性肺疾病相关性的研究进展. 中国慢性病预防与控制, 2014, 22(1): 110-112.
9. 雒志明, 马丽娜, 聂秀红, 等. 吸烟对 COPD 患者肺功能的影响. 临床肺科杂志, 2011, 16(8): 1250-1251.
10. 陈勃江, 李为民, 袁玉茹. 吸烟对无呼吸道症状个体肺功能的影响. 中华肺部疾病杂志: 电子版, 2011, 4(6): 483-486.
11. 王晓如, 孔庆华, 范颖, 等. 吸烟与老年慢性阻塞性肺疾病患者肺功能受损程度相关性分析. 中国临床医学, 2011, 18(6): 794-796.
12. Melzer AC, Feemster LC, Crothers K, et al. Respiratory and bronchitic symptoms predict intention to quit smoking among current smokers with, and at risk for, chronic obstructive pulmonary disease. Ann Am Thorac Soc, 2016, 13(9): 1490-1496.
13. 罗勤利. 戒烟干预对不同风险程度慢性阻塞性肺疾病患者预后的影响对比. 临床肺科杂志, 2015, 20(6): 1076-1079.
14. 王聪颖, 张庆, 王少飞, 等. 不同风险慢性阻塞性肺疾病患者戒烟干预后临床症状及肺功能变化研究. 中国全科医学, 2014, 17(1): 50-52.

Previous Article
Relationship between blood pressure variability and pulse wave velocity in patients with hypertension CAIYali, WANG Si, ZHANG Xin, ZHU Xiaojiang, LIU Qi, ZHANG Qiang, CHEN Xiaoping
Next Article
Clinical characteristics of 41 cases of primary salivary glandtype lung cancer YANGLiqing, YANG Xiaodong, ZHANG Yi, HU Qiufang, WANG Yan, CHEN Xuping, ZHOU Zhenxing

West China Medical Journal

Effect of smoking on pulmonary function of male patients with chronic obstructive pulmonary disease and their correlation

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content