Research Progress of Immunological Rejection in Tracheal Allograft_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIUXing-chen , SUNFei ,  SHIHong-can

Department of General Thoracic Surgery, Medical College of Yangzhou University, Yangzhou, 225001, Jiangsu, P. R. China;

Corresponding author：

SHIHong-can, Email: shihongcan@hotmail.com

Keywords：

Immunological rejection; Tracheal transplantation; Allograft

DOI：

10.7507/1007-4848.20150020

Video：

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A variety of benign and malignant disorders affecting the trachea can theoretically be treated by simple resection and subsequent end-to-end anastomosis of remained trachea. Unfortunately, it is feasible only when the affected tracheal length does not exceed 50% of the entire length in adults and about 30% in children. Tracheal transplantation may be a treatment option for those patients, but still has many problems to be solved, such as immunological rejection, revascularization, infection and granulation tissue hyperplasia. This review focuses on how to use different methods to inhibit immunological rejection of tracheal transplantation, and current research progress of immunological rejection in tracheal allograft.

Citation： LIUXing-chen, SUNFei, SHIHong-can. Research Progress of Immunological Rejection in Tracheal Allograft. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(1): 71-74. doi: 10.7507/1007-4848.20150020 Copy

1.	Vacanti CA, Upton J. Tissue engineered morphogenesis of cartilage and bone by means of cell transplantat ion using synthetic biodegradable polymer matrices. Clin Plast Surg, 1994, 21(3):445-462.
2.	Steger V, Hampel M, Trick I, et al. Clinical tracheal replacement:transplantation, bioprostheses and artificial grafts. Expert Rev Med Devices, 2008, 5(5):605-612.
3.	Klepetko W, Marta GM, Wisser W, et al. Heterotopic tracheal transplantation with omentum wrapping in the abdominal position preserves functional and structural integrity of a human tracheal allograft. Thorac Cardiovasc Surg, 2004, 127(3):862-867.
4.	Rees LE, Ayoub O, Haverson K, et al. Differential major histocompatibility complex class Ⅱ locus expression on human laryngeal epithelium. Clin Exp Immunol, 2003, 134(3):497-502.
5.	Yokomise H, Inui K, Wada H, et al. High-dose irradiation prevents rejection of canine tracheal allografts. Thorac Cardiovasc Surg, 1994, 107(6):1391-1397.
6.	Yokomise H, Inui K, Wada H, et al. The infeasibility of using tenring irradiated grafts for tracheal allotransplantation even with omentopexy. Surg Today, 1996, 26(6):427-430.
7.	Makris D, Holder-Espinasse M, Wurtz A, et al. Tracheal replacement with cryopreserved allogenic aorta. Chest, 2010, 137(1):60-67.
8.	Radu DM, Seguin A, Bruneval P, et al. Bronchial replacement with arterial allografts. Ann Thorac Surg, 2010, 90(1):252-258.
9.	Martinod E, Radu DM, Chouahnia K, et al. Human Transplantation of a biologic airway substitute in conservative lung cancer surgery. Ann Thorac Surg, 2011, 91(3):837-842.
10.	Tojo T, Kitamura S, Gojo S, et al. Epithelial regeneration and preservation of tracheal cartilage after tracheal replacement with cryopreserved allograft in the rat. Thorac Cardiovasc Surg, 1998, 116(4):624-627.
11.	Mukaida T, Shimizu N, Aoe M, et al. Experimental study of tracheal allotransplantation with cryopreserved grafts. Thorac Cardiovasc Surg, 1998, 116(2):262-266.
12.	Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet, 2008, 372(9655):2023-2030.
13.	Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials, 2011, 32(12):3233-3243.
14.	Jungebluth P, Go T, Asnaghi A, et al. Structural and morphological evaluation of a novel enzymatic detergent tissue engineered tracheal tubular matrix. Thorac Cardiovasc Surg, 2009, 138(3):586-593.
15.	Go T, Jungebluth P, Baiguero S, et al. Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. Thorac Cardiovasc Surg, 2010, 139(2):437-443.
16.	孙飞, 潘枢, 史宏灿. 去污剂-联合酶法行兔脱细胞组织工程气管制备及性能评价. 中华胸心血管外科杂志, 2014, 30(1):38-55.
17.	章方彪, 张卫东, 史宏灿. 细胞外基质在长段气管病损治疗中的应用与研究进展. 中国胸心血管外科临床杂志, 2013, 20(3):334-337.
18.	Baiguera S, Gonfiotti A, Jaus M, et al. Development of bioengineered human larynx. Biomaterials, 2011, 32(19):4433-4442.
19.	Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials, 2006, 27(19):3675-3683.
20.	Delaere PR, Hermans R. Clinical transplantation of a tissueengineered airway. Lancet, 2009, 3739(9665):717-718.
21.	Pierre D, Jan V, Geert V, et al. Tracheal allotransplantation after withdrawal of immunosuppressive therapy. N Engl J Med, 2010, 362(2):138-145.
22.	Shalev I, Schmelzle M, Robson SC, et al. Making sense of regulatory T cell suppressive function. Semin Immunol, 2011, 23(4):282-292.
23.	Sojka DK, Huang YH, Fowell DJ. Mechanisms of regulatory T-cell suppression-a diverse arsenal for a moving target. Immunology, 2008, 124(1):13-22.
24.	Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol, 2003, 3(3):199-210.
25.	Kang SM, Tang Q, Bluestone JA. CD4+CD25+ regulatory T cells in transplantation:progress, challenges and prospects. Am J Transplant, 2007, 7(6):1457-1463.
26.	Li W, Carper K, Zheng XX, et al. The role of Foxp3t regulatory T cells in liver transplant tolerance. Transplant Proc, 2006, 38(10):3205-3206.
27.	Long E, Wood KJ. Regulatory T cells in transplantation:transferring mouse studies to the clinic. Transplantation, 2009, 88(9):1050-1056.
28.	BluestoneJA, Tang Q. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci USA, 2004, 101(Suppl 2):14622-14626.
29.	Sugimoto K, Itoh T, Takita M, et al. Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors. Transpl Int, 2014, 27(4):408-415.
30.	Pasquet L, Douet JY, Sparwasser T, et al. Long term prevention of chronic allograft rejection by regulatory T cell immunotherapy involves host Foxp3-expressing T cells. Blood, 2013, 121(21):4303-4310.
31.	Haag J, Baiguera S, Jungebluth P, et al. Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin crosslinked decellularized tissue. Biomaterials, 2012, 33(3):780-789.

1. Vacanti CA, Upton J. Tissue engineered morphogenesis of cartilage and bone by means of cell transplantat ion using synthetic biodegradable polymer matrices. Clin Plast Surg, 1994, 21(3):445-462.
2. Steger V, Hampel M, Trick I, et al. Clinical tracheal replacement:transplantation, bioprostheses and artificial grafts. Expert Rev Med Devices, 2008, 5(5):605-612.
3. Klepetko W, Marta GM, Wisser W, et al. Heterotopic tracheal transplantation with omentum wrapping in the abdominal position preserves functional and structural integrity of a human tracheal allograft. Thorac Cardiovasc Surg, 2004, 127(3):862-867.
4. Rees LE, Ayoub O, Haverson K, et al. Differential major histocompatibility complex class Ⅱ locus expression on human laryngeal epithelium. Clin Exp Immunol, 2003, 134(3):497-502.
5. Yokomise H, Inui K, Wada H, et al. High-dose irradiation prevents rejection of canine tracheal allografts. Thorac Cardiovasc Surg, 1994, 107(6):1391-1397.
6. Yokomise H, Inui K, Wada H, et al. The infeasibility of using tenring irradiated grafts for tracheal allotransplantation even with omentopexy. Surg Today, 1996, 26(6):427-430.
7. Makris D, Holder-Espinasse M, Wurtz A, et al. Tracheal replacement with cryopreserved allogenic aorta. Chest, 2010, 137(1):60-67.
8. Radu DM, Seguin A, Bruneval P, et al. Bronchial replacement with arterial allografts. Ann Thorac Surg, 2010, 90(1):252-258.
9. Martinod E, Radu DM, Chouahnia K, et al. Human Transplantation of a biologic airway substitute in conservative lung cancer surgery. Ann Thorac Surg, 2011, 91(3):837-842.
10. Tojo T, Kitamura S, Gojo S, et al. Epithelial regeneration and preservation of tracheal cartilage after tracheal replacement with cryopreserved allograft in the rat. Thorac Cardiovasc Surg, 1998, 116(4):624-627.
11. Mukaida T, Shimizu N, Aoe M, et al. Experimental study of tracheal allotransplantation with cryopreserved grafts. Thorac Cardiovasc Surg, 1998, 116(2):262-266.
12. Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet, 2008, 372(9655):2023-2030.
13. Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials, 2011, 32(12):3233-3243.
14. Jungebluth P, Go T, Asnaghi A, et al. Structural and morphological evaluation of a novel enzymatic detergent tissue engineered tracheal tubular matrix. Thorac Cardiovasc Surg, 2009, 138(3):586-593.
15. Go T, Jungebluth P, Baiguero S, et al. Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. Thorac Cardiovasc Surg, 2010, 139(2):437-443.
16. 孙飞, 潘枢, 史宏灿. 去污剂-联合酶法行兔脱细胞组织工程气管制备及性能评价. 中华胸心血管外科杂志, 2014, 30(1):38-55.
17. 章方彪, 张卫东, 史宏灿. 细胞外基质在长段气管病损治疗中的应用与研究进展. 中国胸心血管外科临床杂志, 2013, 20(3):334-337.
18. Baiguera S, Gonfiotti A, Jaus M, et al. Development of bioengineered human larynx. Biomaterials, 2011, 32(19):4433-4442.
19. Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials, 2006, 27(19):3675-3683.
20. Delaere PR, Hermans R. Clinical transplantation of a tissueengineered airway. Lancet, 2009, 3739(9665):717-718.
21. Pierre D, Jan V, Geert V, et al. Tracheal allotransplantation after withdrawal of immunosuppressive therapy. N Engl J Med, 2010, 362(2):138-145.
22. Shalev I, Schmelzle M, Robson SC, et al. Making sense of regulatory T cell suppressive function. Semin Immunol, 2011, 23(4):282-292.
23. Sojka DK, Huang YH, Fowell DJ. Mechanisms of regulatory T-cell suppression-a diverse arsenal for a moving target. Immunology, 2008, 124(1):13-22.
24. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol, 2003, 3(3):199-210.
25. Kang SM, Tang Q, Bluestone JA. CD4+CD25+ regulatory T cells in transplantation:progress, challenges and prospects. Am J Transplant, 2007, 7(6):1457-1463.
26. Li W, Carper K, Zheng XX, et al. The role of Foxp3t regulatory T cells in liver transplant tolerance. Transplant Proc, 2006, 38(10):3205-3206.
27. Long E, Wood KJ. Regulatory T cells in transplantation:transferring mouse studies to the clinic. Transplantation, 2009, 88(9):1050-1056.
28. BluestoneJA, Tang Q. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci USA, 2004, 101(Suppl 2):14622-14626.
29. Sugimoto K, Itoh T, Takita M, et al. Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors. Transpl Int, 2014, 27(4):408-415.
30. Pasquet L, Douet JY, Sparwasser T, et al. Long term prevention of chronic allograft rejection by regulatory T cell immunotherapy involves host Foxp3-expressing T cells. Blood, 2013, 121(21):4303-4310.
31. Haag J, Baiguera S, Jungebluth P, et al. Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin crosslinked decellularized tissue. Biomaterials, 2012, 33(3):780-789.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research Progress of Immunological Rejection in Tracheal Allograft

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