The molecular landscape of noninvasive follicular thyroid neoplasm with papillary-like nuclear features_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Yichao ¹ , XIANG Lijuan ² , ZHOU Ping ³ , ZHAO Wanjun ² ,  ZHU Jingqiang ¹

1. Department of Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Department of Wound Therapeutic Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
3. Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

ZHU Jingqiang, Email: zjq-wkys@163.com

Keywords：

noninvasive follicular thyroid neoplasm with papillary-like nuclear features; molecular research; review

DOI：

10.7507/1007-9424.201807051

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective The aim of this study is to review the molecular landscape of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Method The relevant literatures about molecular profiling of NIFTP were retrospectively analyzed and summarized. Results The most common mutation in NIFTP was rat sarcoma viral oncogene homolog (RAS) mutation. B-type RAF (BRAF^K601E) mutation, PPARG fusion, and THADA fusion also could be seen. There was usually no BRAF^V600E mutation. miRNAs also were found to be differentially expressed in NIFTP. Conclusion The molecular profiling of NIFTP may become a new molecular marker for the diagnosis of NIFTP.

Citation： WANG Yichao, XIANG Lijuan, ZHOU Ping, ZHAO Wanjun, ZHU Jingqiang. The molecular landscape of noninvasive follicular thyroid neoplasm with papillary-like nuclear features. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(1): 110-115. doi: 10.7507/1007-9424.201807051 Copy

1.	Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid, 2016, 26(1): 1-133.
2.	Liu Y, Su L, Xiao H. Review of factors related to the thyroid cancer epidemic. Int J Endocrinol, 2017, 2017: 5308635.
3.	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin, 2018, 68(1): 7-30.
4.	Sipos JA, Mazzaferri EL. Thyroid cancer epidemiology and prognostic variables. Clin Oncol (R Coll Radiol), 2010, 22(6): 395-404.
5.	Lloyd RV, Osamura RY, Kloppel G, et al. WHO classification of tumours of endocrine organs, Lyon, France: IARC, 2017: 1-20.
6.	Mahajan S, Agarwal S, Kocheri N, et al. Cytopathology of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: a comparative study with similar patterned papillary thyroid carcinoma variants. Cytopathology, 2018, 29(3): 233-240.
7.	Lloyd RV, Asa SL, LiVolsi VA, et al. The evolving diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Hum Pathol, 2018, 74: 1-4.
8.	Hung YP, Barletta JA. A user’s guide to non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Histopathology, 2018, 72(1): 53-69.
9.	Ward R. Carcinoma of the thyroid gland: a clinical and pathologic study of 293 patients at the University of California hospital. Calif Med, 1960, 93(4): 261.
10.	Baloch ZW, Shafique K, Flannagan M, et al. Encapsulated classic and follicular variants of papillary thyroid carcinoma: comparative clinicopathologic study. Endocr Pract, 2010, 16(6): 952-959.
11.	Vivero M, Kraft S, Barletta JA. Risk stratification of follicular variant of papillary thyroid carcinoma. Thyroid, 2013, 23(3): 273-279.
12.	Liu J, Singh B, Tallini G, et al. Follicular variant of papillary thyroid carcinoma: a clinicopathologic study of a problematic entity. Cancer, 2006, 107(6): 1255-1264.
13.	Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg, 2014, 140(4): 317-322.
14.	Howitt BE, Jia Y, Sholl LM, et al. Molecular alterations in partially-encapsulated or well-circumscribed follicular variant of papillary thyroid carcinoma. Thyroid, 2013, 23(10): 1256-1262.
15.	Nikiforov YE, Seethala RR, Tallini G, et al. Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol, 2016, 2(8): 1023-1029.
16.	Jiang XS, Harrison GP, Datto MB. Young investigator challenge: molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Cancer Cytopathol, 2016, 124(12): 893-900.
17.	Bizzarro T, Martini M, Capodimonti S, et al. Young investigator challenge: the morphologic analysis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on liquid-based cytology: some insights into their identification. Cancer Cytopathol, 2016, 124(10): 699-710.
18.	Paulson VA, Shivdasani P, Angell TE, et al. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features accounts for more than half of " carcinomas” harboring RAS mutations. Thyroid, 2017, 27(4): 506-511.
19.	Giannini R, Ugolini C, Poma AM, et al. Identification of two distinct molecular subtypes of non-invasive follicular neoplasm with papillary-like nuclear features by digital RNA counting. Thyroid, 2017, 27(10): 1267-1276.
20.	Zhao L, Dias-Santagata D, Sadow PM, et al. Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma. Cancer Cytopathol, 2017, 125(5): 323-331.
21.	Cho U, Mete O, Kim MH, et al. Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features. Mod Pathol, 2017, 30(6): 810-825.
22.	Lee SE, Hwang TS, Choi YL, et al. Molecular profiling of papillary thyroid carcinoma in Korea with a high prevalence of BRAF thyroid. Thyroid, 2017, 27(6): 802-810.
23.	Kim M, Jeon MJ, Oh HS, et al. BRAF and RAS mutational status in noninvasive follicular thyroid neoplasm with papillary-like nuclear features and invasive subtype of encapsulated follicular variant of papillary thyroid carcinoma in Korea. Thyroid, 2018, 28(4): 504-510.
24.	Strickland KC, Eszlinger M, Paschke R, et al. Molecular testing of nodules with a suspicious or malignant cytologic diagnosis in the setting of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Endocr Pathol, 2018, 29(1): 68-74.
25.	du Jour KP, Schmitt AC, Chen AY, et al. Application of strict criteria for noninvasive follicular thyroid neoplasm with papillary-like nuclear features and encapsulated follicular variant papillary thyroid carcinoma: a retrospective study of 50 tumors previously diagnosed as follicular vriant PTC. Endocr Pathol, 2018, 29(1): 35-42.
26.	Wang Z, Wang W, Huang K, et al. MicroRNA-34a inhibits cells proliferation and invasion by downregulating Notch1 in endometrial cancer. Oncotarget, 2017, 8(67): 111258-111270.
27.	Cui XB, Peng H, Li RR, et al. MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma. Oncotarget, 2017, 8(54): 92454-92469.
28.	Song L, Peng L, Hua S, et al. miR-144-5p enhances the radiosensitivity of non-small-cell lung cancer cells via targeting ATF2. Biomed Res Int, 2018, 2018: 5109497.
29.	Chen K, Chen Y, Chen Z, et al. miR-134 increases the antitumor effects of cytarabine by targeting Mnks in acute myeloid leukemia cells. Onco Targets Ther, 2018, 11: 3141-3147.
30.	Han L, Chen W, Xia Y, et al. MiR-101 inhibits the proliferation and metastasis of lung cancer by targeting zinc finger E-box binding homeobox 1. Am J Transl Res, 2018, 10(4): 1172-1183.
31.	Sun W, Lan X, Wang Z, et al. MicroRNA-144 inhibits proliferation by targeting WW domain-containing transcription regulator protein 1 in papillary thyroid cancer. Oncol Lett, 2018, 15(1): 1007-1013.
32.	Stefanescu H, Muntean D, Pilut C, et al. Using blood and plasma microRNAs as a non-invasive biomarker in patients with colorectal cancer. Clin Lab, 2018, 64(3): 257-262.
33.	Xia D, Li X, Niu Q, et al. MicroRNA-185 suppresses pancreatic cell proliferation by targeting transcriptional coactivator with PDZ-binding motif in pancreatic cancer. Exp Ther Med, 2018, 15(1): 657-666.
34.	Borrelli N, Denaro M, Ugolini C, et al. miRNA expression profiling of ‘noninvasive follicular thyroid neoplasms with papillary-like nuclear features’ compared with adenomas and infiltrative follicular variants of papillary thyroid carcinomas. Mod Pathol, 2017, 30(1): 39-51.
35.	Jahanbani I, Al-Abdallah A, Ali RH, et al. Discriminatory miRNAs for the management of papillary thyroid carcinoma and noninvasive follicular thyroid neoplasms with papillary-like nuclear features. Thyroid, 2018, 28(3): 319-327.

1. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid, 2016, 26(1): 1-133.
2. Liu Y, Su L, Xiao H. Review of factors related to the thyroid cancer epidemic. Int J Endocrinol, 2017, 2017: 5308635.
3. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin, 2018, 68(1): 7-30.
4. Sipos JA, Mazzaferri EL. Thyroid cancer epidemiology and prognostic variables. Clin Oncol (R Coll Radiol), 2010, 22(6): 395-404.
5. Lloyd RV, Osamura RY, Kloppel G, et al. WHO classification of tumours of endocrine organs, Lyon, France: IARC, 2017: 1-20.
6. Mahajan S, Agarwal S, Kocheri N, et al. Cytopathology of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: a comparative study with similar patterned papillary thyroid carcinoma variants. Cytopathology, 2018, 29(3): 233-240.
7. Lloyd RV, Asa SL, LiVolsi VA, et al. The evolving diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Hum Pathol, 2018, 74: 1-4.
8. Hung YP, Barletta JA. A user’s guide to non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Histopathology, 2018, 72(1): 53-69.
9. Ward R. Carcinoma of the thyroid gland: a clinical and pathologic study of 293 patients at the University of California hospital. Calif Med, 1960, 93(4): 261.
10. Baloch ZW, Shafique K, Flannagan M, et al. Encapsulated classic and follicular variants of papillary thyroid carcinoma: comparative clinicopathologic study. Endocr Pract, 2010, 16(6): 952-959.
11. Vivero M, Kraft S, Barletta JA. Risk stratification of follicular variant of papillary thyroid carcinoma. Thyroid, 2013, 23(3): 273-279.
12. Liu J, Singh B, Tallini G, et al. Follicular variant of papillary thyroid carcinoma: a clinicopathologic study of a problematic entity. Cancer, 2006, 107(6): 1255-1264.
13. Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg, 2014, 140(4): 317-322.
14. Howitt BE, Jia Y, Sholl LM, et al. Molecular alterations in partially-encapsulated or well-circumscribed follicular variant of papillary thyroid carcinoma. Thyroid, 2013, 23(10): 1256-1262.
15. Nikiforov YE, Seethala RR, Tallini G, et al. Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol, 2016, 2(8): 1023-1029.
16. Jiang XS, Harrison GP, Datto MB. Young investigator challenge: molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Cancer Cytopathol, 2016, 124(12): 893-900.
17. Bizzarro T, Martini M, Capodimonti S, et al. Young investigator challenge: the morphologic analysis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on liquid-based cytology: some insights into their identification. Cancer Cytopathol, 2016, 124(10): 699-710.
18. Paulson VA, Shivdasani P, Angell TE, et al. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features accounts for more than half of " carcinomas” harboring RAS mutations. Thyroid, 2017, 27(4): 506-511.
19. Giannini R, Ugolini C, Poma AM, et al. Identification of two distinct molecular subtypes of non-invasive follicular neoplasm with papillary-like nuclear features by digital RNA counting. Thyroid, 2017, 27(10): 1267-1276.
20. Zhao L, Dias-Santagata D, Sadow PM, et al. Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma. Cancer Cytopathol, 2017, 125(5): 323-331.
21. Cho U, Mete O, Kim MH, et al. Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features. Mod Pathol, 2017, 30(6): 810-825.
22. Lee SE, Hwang TS, Choi YL, et al. Molecular profiling of papillary thyroid carcinoma in Korea with a high prevalence of BRAF thyroid. Thyroid, 2017, 27(6): 802-810.
23. Kim M, Jeon MJ, Oh HS, et al. BRAF and RAS mutational status in noninvasive follicular thyroid neoplasm with papillary-like nuclear features and invasive subtype of encapsulated follicular variant of papillary thyroid carcinoma in Korea. Thyroid, 2018, 28(4): 504-510.
24. Strickland KC, Eszlinger M, Paschke R, et al. Molecular testing of nodules with a suspicious or malignant cytologic diagnosis in the setting of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Endocr Pathol, 2018, 29(1): 68-74.
25. du Jour KP, Schmitt AC, Chen AY, et al. Application of strict criteria for noninvasive follicular thyroid neoplasm with papillary-like nuclear features and encapsulated follicular variant papillary thyroid carcinoma: a retrospective study of 50 tumors previously diagnosed as follicular vriant PTC. Endocr Pathol, 2018, 29(1): 35-42.
26. Wang Z, Wang W, Huang K, et al. MicroRNA-34a inhibits cells proliferation and invasion by downregulating Notch1 in endometrial cancer. Oncotarget, 2017, 8(67): 111258-111270.
27. Cui XB, Peng H, Li RR, et al. MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma. Oncotarget, 2017, 8(54): 92454-92469.
28. Song L, Peng L, Hua S, et al. miR-144-5p enhances the radiosensitivity of non-small-cell lung cancer cells via targeting ATF2. Biomed Res Int, 2018, 2018: 5109497.
29. Chen K, Chen Y, Chen Z, et al. miR-134 increases the antitumor effects of cytarabine by targeting Mnks in acute myeloid leukemia cells. Onco Targets Ther, 2018, 11: 3141-3147.
30. Han L, Chen W, Xia Y, et al. MiR-101 inhibits the proliferation and metastasis of lung cancer by targeting zinc finger E-box binding homeobox 1. Am J Transl Res, 2018, 10(4): 1172-1183.
31. Sun W, Lan X, Wang Z, et al. MicroRNA-144 inhibits proliferation by targeting WW domain-containing transcription regulator protein 1 in papillary thyroid cancer. Oncol Lett, 2018, 15(1): 1007-1013.
32. Stefanescu H, Muntean D, Pilut C, et al. Using blood and plasma microRNAs as a non-invasive biomarker in patients with colorectal cancer. Clin Lab, 2018, 64(3): 257-262.
33. Xia D, Li X, Niu Q, et al. MicroRNA-185 suppresses pancreatic cell proliferation by targeting transcriptional coactivator with PDZ-binding motif in pancreatic cancer. Exp Ther Med, 2018, 15(1): 657-666.
34. Borrelli N, Denaro M, Ugolini C, et al. miRNA expression profiling of ‘noninvasive follicular thyroid neoplasms with papillary-like nuclear features’ compared with adenomas and infiltrative follicular variants of papillary thyroid carcinomas. Mod Pathol, 2017, 30(1): 39-51.
35. Jahanbani I, Al-Abdallah A, Ali RH, et al. Discriminatory miRNAs for the management of papillary thyroid carcinoma and noninvasive follicular thyroid neoplasms with papillary-like nuclear features. Thyroid, 2018, 28(3): 319-327.

Previous Article
腹主动脉瘤腔内修复术后Ⅱ型内漏治疗进展
Next Article
Research progress of pathogenetic and development mechanism of phyllodes tumor of breast

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The molecular landscape of noninvasive follicular thyroid neoplasm with papillary-like nuclear features

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content