Objective To investigate the risk factors, clinical characteristics and prognostic factors of venous thrombosis (and pulmonary embolism) in patients with idiopathic hypereosinophilia (IHE) so as to provide a theoretical basis for clinical prevention of venous thrombosis and improve prognosis.Methods Thirty-nine patients with IHE admitted to West China Hospital of Sichuan University from January 2010 to January 2022 were collected in this retrospective case-control study to explore the risk factors of venous thrombosis (including pulmonary embolism) and thrombosis recurrence after treatment. Results There were 17 (43.5%) patients combined with venous thrombosis of 39 patients with IHE. In the patients with vascular involvement, pulmonary embolism was the initial expression of IHE accounted for 29% (5/17). patients of IHE with pulmonary embolism were younger [44 (24.5 - 51.0) vs. 56 (46.3 - 67.8) year, P=0.035] and had higher peak absolute eosinophil counts [11.7 (7.2 - 26.5)×109/L vs. 3.8 (2.9 - 6.7)×109/L, P=0.020] than those without pulmonary embolism. After a mean follow-up of 13 months (2 - 21 months), thrombosis recurred in 35.3% (6/17) of patients. Persistent increasing in eosinophils (>0.5×109/L) was an independent risk factor for thrombus recurrence (odds ratio 13.33, 95% confidential interval 1.069 - 166.374). Conclusions Thrombosis is a common vascular impaired complication in IHE , and increased eosinophilia is a risk factor for thrombosis and thrombus recurrence after therapy. Controlling and monitoring the eosinophilic cell levels in patients with IHE may avoid severe comorbidities.
Citation:
LI Qinxue, FENG Xiaoyi, OU Xuemei. A case-control study of idiopathic hypereosinophilia combined with thrombosis and recurrence. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(10): 716-721. doi: 10.7507/1671-6205.202301018
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贾金靖, 陈达灿, 郑焱. 特发性嗜酸性粒细胞增多症伴下肢动脉血栓形成1例. 中国皮肤性病学杂志, 2020, 34(1): 118-120.
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Khan F, Tritschler T, Kahn SR, et al. Venous thromboembolism. Lancet, 2021, 398(10294): 64-77.
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Réau V, Vallée A, Terrier B, et al. Venous thrombosis and predictors of relapse in eosinophil-related diseases. Sci Rep, 2021, 11(1): 6388.
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王子熹. 嗜酸性粒细胞增多综合征的诊断与治疗. 中华临床免疫和变态反应杂志, 2021, 15(1): 108-109.
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Liu YC, Meng X, Feng J, et al. Hypereosinophilia with concurrent venous thromboembolism: clinical features, potential risk factors, and short-term outcomes in a Chinese cohort. Sci Rep, 2020, 10(1): 8359.
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何静, 王军, 杨涛. 静脉血栓栓塞症患者外周血嗜酸性粒细胞与血小板、凝血功能指标、C-反应蛋白的相关性分析. 中国普通外科杂志, 2018, 27(12): 1531-1538.
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Lippi G, Montagnana M, Salvagno GL, et al. Eosinophilia and first-line coagulation testing. J Thromb Thrombolysis, 2009, 28(1): 90-93.
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- 1. 贾金靖, 陈达灿, 郑焱. 特发性嗜酸性粒细胞增多症伴下肢动脉血栓形成1例. 中国皮肤性病学杂志, 2020, 34(1): 118-120.
- 2. Todd S, Hemmaway C, Nagy Z. Catastrophic thrombosis in idiopathic hypereosinophilic syndrome. Br J Haematol, 2014, 165(4): 425.
- 3. 中华医学会血液学分会白血病淋巴瘤学组. 嗜酸粒细胞增多症诊断与治疗中国专家共识(2017年版). 中华血液学杂志, 2017, 38(7): 561-565.
- 4. Shomali W, Gotlib J. World Health Organization-defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management. Am J Hematol, 2019, 94(10): 1149-1167.
- 5. Khan F, Tritschler T, Kahn SR, et al. Venous thromboembolism. Lancet, 2021, 398(10294): 64-77.
- 6. Réau V, Vallée A, Terrier B, et al. Venous thrombosis and predictors of relapse in eosinophil-related diseases. Sci Rep, 2021, 11(1): 6388.
- 7. 王子熹. 嗜酸性粒细胞增多综合征的诊断与治疗. 中华临床免疫和变态反应杂志, 2021, 15(1): 108-109.
- 8. Liu YC, Meng X, Feng J, et al. Hypereosinophilia with concurrent venous thromboembolism: clinical features, potential risk factors, and short-term outcomes in a Chinese cohort. Sci Rep, 2020, 10(1): 8359.
- 9. 何静, 王军, 杨涛. 静脉血栓栓塞症患者外周血嗜酸性粒细胞与血小板、凝血功能指标、C-反应蛋白的相关性分析. 中国普通外科杂志, 2018, 27(12): 1531-1538.
- 10. Lippi G, Montagnana M, Salvagno GL, et al. Eosinophilia and first-line coagulation testing. J Thromb Thrombolysis, 2009, 28(1): 90-93.