Association between periodontal disease and gastric cancer risk: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Binghui ^1,2,3 , MENG Jiming ^1,2,3 , WANG Chaoyang ^1,2,3 , ZHENG Zhongli ^1,2,3 , ZI Hao ^2,3,4 , CHEN Shaohua ^2,3 , ZENG Xiantao ^2,3,5,6,7,8 ,  REN Xuequn ^1,2,3

1. Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
2. Center for Evidence-Based Medicine, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
3. Center for Evidence-Based Medicine, Henan University, Kaifeng, 475000, P.R.China;
4. Department of Urology, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
5. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P.R.China;
6. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan, 430071, P.R.China;
7. Department of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical Medical College, Wuhan University, Wuhan, 430071, P.R.China;
8. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, P.R.China;

Corresponding author：

REN Xuequn, Email: renxuequn001@163.com

Keywords：

Gastric cancer; Periodontal disease; Periodontitis; Case-control studies; Cohort studies; Meta-analysis

DOI：

10.7507/1672-2531.201703145

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Objective To systematically review the relationship between periodontal disease and gastric cancer risk. Methods We retrieved PubMed, EMbase, CNKI, WanFang Data, VIP, and CBM databases to collect studies about the correlation between periodontal disease and gastric cancer from inception to January 31^st, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results Five studies were included. The results of meta-analysis showed that there was no significant correlation between periodontal disease and gastric cancer (RR=0.99, 95%CI 0.83 to 1.19, P=0.93). Sensitivity analysis showed good stability. Subgroup analysis showed that the type of study, race and type of effect size have no statistically impact on the outcome, there was no significant correlation between periodontal disease and gastric cancer. Conclusion According to the current evidence, periodontal disease probably is not a risk factor of gastric cancer. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify above conclusion.

Citation： LI Binghui, MENG Jiming, WANG Chaoyang, ZHENG Zhongli, ZI Hao, CHEN Shaohua, ZENG Xiantao, REN Xuequn. Association between periodontal disease and gastric cancer risk: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(10): 1183-1187. doi: 10.7507/1672-2531.201703145 Copy

1.	陈万青, 郑荣寿, 张思维, 等. 2012 年中国恶性肿瘤发病和死亡分析. 中国肿瘤, 2016, 25(1): 1-8.0.
2.	张惠珍, 王佩英. 牙周病与幽门螺杆菌相关性的观察研究. 浙江临床医学, 2005, 7(8): 808.0.
3.	Watabe K, Nishi M, Miyake H, et al. Lifestyle and gastric cancer: a case-control study. Oncol Rep, 1998, 5(5): 1191-1194.
4.	Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. Lancet Oncol, 2008, 9(6): 550-558.
5.	Hujoel PP, Drangsholt M, Spiekerman C, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol, 2003, 13(5): 312-316.
6.	Arora M, Weuve J, Fall K, et al. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol, 2010, 171(2): 253-259.
7.	Wen BW, Tsai CS, Lin CL, et al. Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. QJM, 2014, 107(4): 283-290.
8.	曾宪涛, 李胜, 马钻, 等. Meta 分析系列之八: Meta 分析的报告规范. 中国循证心血管医学杂志, 2012, 4(6): 500-503.0.
9.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
10.	文进, 李幼平. Meta 分析中效应尺度指标的选择. 中国循证医学杂志, 2007, 7(8): 606-613.0.
11.	罗杰, 冷卫东, 主编. 系统评价/Meta 分析理论与实践. 第一版. 北京: 军事医学科学出版社, 2013: 106-108.
12.	Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
13.	Linden GJ, Herzberg MC. Periodontitis and systemic diseases: a record of discussions of working group 4 of the joint EFP/AAP workshop on periodontitis and systemic diseases. J Clin Periodontol, 2013, 40(S14): 20-23.
14.	刘文斌, 曹广文. 癌症进化发育学: 基于炎-癌转化研究的新学说. 中国肿瘤生物治疗杂志, 2017, 24(2): 103-111.0.
15.	Adler I, Muino A, Aguas S, et al. Helicobacter pylori and oral pathology: relationship with the gastric infection. World J Gastroenterol, 2014, 20(29): 9922-9935.
16.	Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol, 2006, 12(1): 17-20.
17.	田文静, 王滨有, 张建中, 等. 中国幽门螺杆菌感染与胃癌关系的 Meta 分析. 中国循证医学杂志, 2006, 6(11): 833-838.0.
18.	Tsugane S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci, 2005, 96(1): 1-6.
19.	鲍萍萍, 陶梦华, 刘大可, 等. 吸烟、饮酒与胃癌关系的病例对照研究. 肿瘤, 2001, 21(5): 334-338.0.
20.	Duell EJ, Travier N, Lujan-Barroso L, et al. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr, 2011, 94(5): 1266-1275.
21.	Krajden S, Fuksa M, Anderson J, et al. Examination of human stomach biopsies, saliva, and dental plaque for campylobacter pylori. J Clin Microbiol, 1989, 27(6): 1397-1398.
22.	张和平, 曹红勇, 袁爱华. 抗炎症治疗胃癌的原理和进展. 现代医学, 2013, 41(8): 605-609.0.

1. 陈万青, 郑荣寿, 张思维, 等. 2012 年中国恶性肿瘤发病和死亡分析. 中国肿瘤, 2016, 25(1): 1-8.0.
2. 张惠珍, 王佩英. 牙周病与幽门螺杆菌相关性的观察研究. 浙江临床医学, 2005, 7(8): 808.0.
3. Watabe K, Nishi M, Miyake H, et al. Lifestyle and gastric cancer: a case-control study. Oncol Rep, 1998, 5(5): 1191-1194.
4. Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. Lancet Oncol, 2008, 9(6): 550-558.
5. Hujoel PP, Drangsholt M, Spiekerman C, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol, 2003, 13(5): 312-316.
6. Arora M, Weuve J, Fall K, et al. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol, 2010, 171(2): 253-259.
7. Wen BW, Tsai CS, Lin CL, et al. Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. QJM, 2014, 107(4): 283-290.
8. 曾宪涛, 李胜, 马钻, 等. Meta 分析系列之八: Meta 分析的报告规范. 中国循证心血管医学杂志, 2012, 4(6): 500-503.0.
9. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
10. 文进, 李幼平. Meta 分析中效应尺度指标的选择. 中国循证医学杂志, 2007, 7(8): 606-613.0.
11. 罗杰, 冷卫东, 主编. 系统评价/Meta 分析理论与实践. 第一版. 北京: 军事医学科学出版社, 2013: 106-108.
12. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
13. Linden GJ, Herzberg MC. Periodontitis and systemic diseases: a record of discussions of working group 4 of the joint EFP/AAP workshop on periodontitis and systemic diseases. J Clin Periodontol, 2013, 40(S14): 20-23.
14. 刘文斌, 曹广文. 癌症进化发育学: 基于炎-癌转化研究的新学说. 中国肿瘤生物治疗杂志, 2017, 24(2): 103-111.0.
15. Adler I, Muino A, Aguas S, et al. Helicobacter pylori and oral pathology: relationship with the gastric infection. World J Gastroenterol, 2014, 20(29): 9922-9935.
16. Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol, 2006, 12(1): 17-20.
17. 田文静, 王滨有, 张建中, 等. 中国幽门螺杆菌感染与胃癌关系的 Meta 分析. 中国循证医学杂志, 2006, 6(11): 833-838.0.
18. Tsugane S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci, 2005, 96(1): 1-6.
19. 鲍萍萍, 陶梦华, 刘大可, 等. 吸烟、饮酒与胃癌关系的病例对照研究. 肿瘤, 2001, 21(5): 334-338.0.
20. Duell EJ, Travier N, Lujan-Barroso L, et al. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr, 2011, 94(5): 1266-1275.
21. Krajden S, Fuksa M, Anderson J, et al. Examination of human stomach biopsies, saliva, and dental plaque for campylobacter pylori. J Clin Microbiol, 1989, 27(6): 1397-1398.
22. 张和平, 曹红勇, 袁爱华. 抗炎症治疗胃癌的原理和进展. 现代医学, 2013, 41(8): 605-609.0.

Chinese Journal of Evidence-Based Medicine

Association between periodontal disease and gastric cancer risk: a meta-analysis

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