Construct the evaluation index domain of traditional Chinese medicine treatment of ischemic stroke_Chinese Journal of Evidence-Based Medicine

Authors：

 LI Chunxiao ^1,2,3 , YANG Yuqing ^1,2 , LING Xiao ^1,2 , XING Dongmei ⁴ , LIU Xiangzhe ⁵

1. Department of Pharmacy, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, P. R. China;
2. Henan Province Engineering Research Center for Clinical Application, Evaluation and Transformation of Traditional Chinese Medicine/Henan Province Engineering Laboratory for Clinical Evaluation Technology of Chinese Medicine, Zhengzhou 450000, P. R. China;
3. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China, Henan University of Chinese Medicine, Zhengzhou 450000, P. R. China;
4. Department of Cardiology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, P. R. China;
5. Department of encephalopathy, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, P. R. China;

Corresponding author：

LI Chunxiao, Email: lichunxiao@126.com

Keywords：

Mixed method research; Index domain; Exploratory sequence design; Traditional Chinese medicine; Ischemic stroke

DOI：

10.7507/1672-2531.202412116

Video：

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Objective A set of core index sets applicable to the treatment of ischemic stroke (IS) by traditional Chinese medicine (TCM) has been constructed to IS as a basis for final determination of core index sets. Methods The exploratory sequence design of mixed methods research (MMR) was used to conduct qualitative research first and quantitative research, and the research model of quantitative research was determined based on the qualitative research results. In the qualitative research stage, focus groups composed of TCM encephalopathy and neurology experts, core indicator set methodology experts, clinical pharmacists of encephalopathy and researchers with more than 10 years of experience were selected by purpose sampling method, and focus group meetings were held around the theme of "indicator domain, indicator hierarchy and indicator attribution". Based on the discussion results, the meeting further designed the quantitative research questionnaire. A questionnaire survey was conducted among medical professionals with TCM background nationwide from September 11 to October 11, 2023, using convenient sampling method. Results In the qualitative research stage, 11 categories of IS index domain were successfully divided, including functional impairment evaluation, imaging index, daily living ability evaluation, TCM therapeutic characteristic index and TCM intervention advantage index. In the quantitative research part, 50 valid questionnaires were collected from 23 hospitals in 13 provinces, with a recovery rate of 76.92%. The recovery rate of the second round was 100%. In the end, the initial list of IS indicators in different stages of disease course was developed. The acute stage included 43 second-level evaluation indexes, 8 third-level evaluation indexes and 87 fourth-level evaluation indexes under 8 index domains. The recovery period includes 45 second-level evaluation indexes, 8 third-level evaluation indexes and 72 fourth-level evaluation indexes under 10 index domains. The sequelae stage included 33 second-level evaluation indicators, 8 third-level evaluation indicators and 70 fourth-level evaluation indicators in 9 indicator domains. Conclusion Based on the exploratory sequence design of MMR, this study successfully divide the index domain that IS scientific, in line with the characteristics of the disease and can reflect the characteristics of the intervention effect of TCM, ensuring the scientific and applicability of the initial IS index list, and laying a solid foundation for the construction of a comprehensive, objective and practical core index set.

Citation： LI Chunxiao, YANG Yuqing, LING Xiao, XING Dongmei, LIU Xiangzhe. Construct the evaluation index domain of traditional Chinese medicine treatment of ischemic stroke. Chinese Journal of Evidence-Based Medicine, 2025, 25(8): 926-931. doi: 10.7507/1672-2531.202412116 Copy

1.
2.
3.
4.
5.
6.
7.	张俊华, 王海南. 临床评价核心指标集研究方法与实践. 上海: 上海科学技术出版社, 2021.
8.	张翔宇. 中医药治疗室性早搏核心指标集研究. 天津: 天津中医药大学, 2022.
9.	崔莹. 基于GRADE分级工具系统评价针灸临床证据质量及核心指标集构建: 原发性抑郁症. 天津: 天津中医药大学, 2022.
10.	李凯. 中医药治疗肺癌核心指标集研究. 天津: 天津中医药大学, 2021.
11.
12.	Creswell JW. 混合方法研究导论. 上海: 上海人民出版社, 2015.
13.	Creswell JW, Clark V. 混合方法研究: 设计与实施. 重庆: 重庆大学出版社, 2017.
14.	王正辉. 焦点小组在博物馆观众评估领域的应用. 济南: 山东大学, 2022.
15.
16.	Cella D, Yount S, Rothrock N, et al. The Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH roadmap cooperative group during its first two years. Med Care, 2007, 45(5 Suppl 1): S3-S11.
17.
18.
19.
20.
21.	吴明隆. 问卷统计分析实务-SPSS操作与应用. 重庆: 重庆大学出版社, 2010.
22.	程超. ICU护理质量敏感性指标体系的构建. 合肥: 安徽医科大学, 2018.
23.
24.
25.
26.
27.
28.
29.	宋晶. 护士工作繁荣的现状及影响因素研究—基于混合研究之探索性序列设计. 青岛: 青岛大学, 2024.
30.
31.	付静, 商洪才. 基于混合方法研究探讨苗医特色外治技术筛选指标体系的构建思路. 世界科学技术-中医药现代化, 2025.
32.
33.
34.
35.
36.
37.	宋立超. 中医药治疗儿童社区获得性肺炎临床研究核心指标集的构建. 沈阳: 辽宁中医药大学, 2021.
38.	代欣玥. 中医药治疗糖尿病足临床研究核心指标集指标域构建研究. 北京: 中国中医科学院, 2021.
39.	曹雪. 中医药治疗早发性卵巢功能不全核心指标集研究. 北京: 中国中医科学院, 2023.
40.
41.	黄柳瑛. 326例缺血性中风后遗症期的中医证型分布与中药用药规律探讨. 南宁: 广西中医药大学, 2023.
42.

1.
2.
3.
4.
5.
6.
7. 张俊华, 王海南. 临床评价核心指标集研究方法与实践. 上海: 上海科学技术出版社, 2021.
8. 张翔宇. 中医药治疗室性早搏核心指标集研究. 天津: 天津中医药大学, 2022.
9. 崔莹. 基于GRADE分级工具系统评价针灸临床证据质量及核心指标集构建: 原发性抑郁症. 天津: 天津中医药大学, 2022.
10. 李凯. 中医药治疗肺癌核心指标集研究. 天津: 天津中医药大学, 2021.
11.
12. Creswell JW. 混合方法研究导论. 上海: 上海人民出版社, 2015.
13. Creswell JW, Clark V. 混合方法研究: 设计与实施. 重庆: 重庆大学出版社, 2017.
14. 王正辉. 焦点小组在博物馆观众评估领域的应用. 济南: 山东大学, 2022.
15.
16. Cella D, Yount S, Rothrock N, et al. The Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH roadmap cooperative group during its first two years. Med Care, 2007, 45(5 Suppl 1): S3-S11.
17.
18.
19.
20.
21. 吴明隆. 问卷统计分析实务-SPSS操作与应用. 重庆: 重庆大学出版社, 2010.
22. 程超. ICU护理质量敏感性指标体系的构建. 合肥: 安徽医科大学, 2018.
23.
24.
25.
26.
27.
28.
29. 宋晶. 护士工作繁荣的现状及影响因素研究—基于混合研究之探索性序列设计. 青岛: 青岛大学, 2024.
30.
31. 付静, 商洪才. 基于混合方法研究探讨苗医特色外治技术筛选指标体系的构建思路. 世界科学技术-中医药现代化, 2025.
32.
33.
34.
35.
36.
37. 宋立超. 中医药治疗儿童社区获得性肺炎临床研究核心指标集的构建. 沈阳: 辽宁中医药大学, 2021.
38. 代欣玥. 中医药治疗糖尿病足临床研究核心指标集指标域构建研究. 北京: 中国中医科学院, 2021.
39. 曹雪. 中医药治疗早发性卵巢功能不全核心指标集研究. 北京: 中国中医科学院, 2023.
40.
41. 黄柳瑛. 326例缺血性中风后遗症期的中医证型分布与中药用药规律探讨. 南宁: 广西中医药大学, 2023.
42.

Chinese Journal of Evidence-Based Medicine

Construct the evaluation index domain of traditional Chinese medicine treatment of ischemic stroke

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