生酮饮食疗法历史浅谈_Journal of Epilepsy

Authors：

 廖建湘 ¹ , 方科伟 ¹ ,  LanXiong ²

1. ;
2. ;

Corresponding author：

LanXiong, Email: lan.xiong@umontreal.ca

Keywords：

生酮饮食; 癫痫; 辟谷; 历史; 断食

DOI：

10.7507/2096-0247.20160074

Video：

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生酮饮食是一种脂肪高比例, 碳水化合物低比例, 蛋白质和其他营养素合适的配方饮食。不仅治疗癫痫, 近来治疗其他疾病也在探索中。生酮饮食的前身是断食治疗, 断食不是完全断绝食物和水, 只是减少热卡, 维持饮水。为了更长时间维持断食的疗效, 1921年美国梅奥诊所出现了生酮饮食疗法。现在约翰.霍普金斯医院领导着全球的生酮饮食治疗。2004年我国大陆生酮饮食疗法临床开始于深圳市儿童医院。中国古老的辟谷疗法, 目前主要用于西医医院以外的养生保健, 操作和西方的断食疗法非常类似, 辟谷大约在2 500多年前就开始存在了。

Citation： 廖建湘, 方科伟, LanXiong. 生酮饮食疗法历史浅谈. Journal of Epilepsy, 2016, 2(5): 418-421. doi: 10.7507/2096-0247.20160074 Copy

1.	Freeman JM, Vining EPG. The efficacy of the ketogenic diet 1998:a prospective evaluation of intervention in 150 children. Pediatrics, 1998, 102(4):1358-1363.
2.	Kossoff EH, Freeman JM, Turner Z, et al. Ketogenic Diets:treatment for Epilepsy and Other Disorders, 5th edition:New York, DEMOS, 2011:39-48.
3.	廖建湘.生酮饮食疗法的临床方案.中华实用儿科临床杂志, 2013, 28(12):881-883.
4.	Wheless JW. History of the ketogenic diet. Epilepsia, 2008, 49(Suppl 8):3-5.
5.	Freeman JM, Vining EP. Seizures decrease rapidly after fasting:preliminarystudies of the ketogenic diet. Arch Pediatr Adolesc Med, 1999, 153(9):946-949.
6.	马王堆汉墓帛书整理小组.马王堆汉墓出土医书释文(一), 文物, 1975, 6:1-5.
7.	Guelpa G, Marie A.Laluttecontrel epilepsieparlades in toxication etparl are educational imentaire. Rev Ther Medico-Chirurgicale, 1911, 78:8-13.
8.	Woodyatt RT. Objects and method of diet adjustment in diabetics. Arch Intern Med, 1921, 28:125-141.
9.	Peterman MG. The ketogenic diet in epilepsy. JAMA, 1925, 84:1979-1983.
10.	Livingston S. Comprehensive management of epilepsy in infancy, childhood and adolescence. Charles C. Thomas, Springfield, IL, 1972:378-405.
11.	Huttenlocher PR. Ketonemia and seizures:metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res, 1976, 10(5):536-540.
12.	Liu YM. Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia, 2008, 49 (Suppl 8):33-36.
13.	Kossoff EH, Cervenka MC, Henry BJ, et al.A decade of themodified Atkins diet (2003-2013):Results, insights, and future directions.Epilepsy Behav, 2013, 29(3):437-442.
14.	Kossoff EH, McGrogan JR, Bluml RM, et al. Amodified Atkins diet is effective for the treatment of intractable pediatricepilepsy. Epilepsia, 2006, 47(2):421-424.
15.	Pfeifer HH, Lyczkowski DA, Thiele EA. Low glycemic index treatment:implementation and new insights into efficacy. Epilepsia, 2008, 49(Suppl8):42-45.
16.	Larson AM, Pfeifer HH, Thiele EA. Low glycemic index treatment for epilepsy intuberous sclerosis complex. Epilepsy Res, 2012, 99(1-2):180-182.
17.	Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet:recommendations of the International Ketogenic Diet Study Group.Epilepsia, 2009, 50(2):304-317.
18.	Kossoff EH, Al-Macki N, Cervenka MC, et al. What are theminimum requirements for ketogenic diet services in resource-limited regions?Recommendations from the International League Against Epilepsy Task Force forDietary Therapy. Epilepsia, 2015, 56(9):1337-1342.
19.	Kossoff EH, McGrogan JR. Worldwide use of the ketogenic diet. Epilepsia, 2015, 46(10):280-289.
20.	Pascual JM, Ronen GM. Glucose Transporter Type I Deficiency (G1D) at 25(1990-2015):presumptions, facts, and the lives of persons with this rare disease. Pediatr Neurol, 2015, 53(5):379-393.
21.	Roubergue A, Philibert B, Gautier A, et al. Excellentresponse to a ketogenic diet in a patient with alternating hemiplegia ofchildhood. JIMD Rep, 2015, 15(5):7-12.
22.	Allen BG, Bhatia SK, Anderson CM, et al. Ketogenic diets as anadjuvant cancer therapy:history and potential mechanism. Redox Biol, 2014, 2(5):963-970.
23.	Spilioti M, Evangeliou AE, Tramma D, et al. Evidence for treatable inborn errors ofmetabolism in a cohort of 187 Greek patients with autism spectrum disorder (ASD).Front Hum Neurosci, 2013, 7(8):858.
24.	Cheng CW, Adams GB, Perin L, et al. Prolonged fasting reduces IGF-1/PKA topromote hematopoietic-stem-cell-based regeneration and reverse immunesuppression.Cell Stem Cell, 2014, 14(6):810-823.Erratumin:Cell Stem Cell, 2016, 18(2):291-292.
25.	Valadao JM, Vigilante JA, DiGeorge NW, et al. Ketogenic diet for high partial pressure oxygendiving. Undersea Hyperb Med, 2014, 41(4):331-335.
26.	Freeman JM, Kossoff EH, Hartman AL.The ketogenic diet:one decade later.Pediatrics, 2007, 119(3):535-543.
27.	李德杏.道教医学辟谷养生术浅析.中华中医药杂志, 2012, 25(5):1230-1232.
28.	王岗, 董调红, 刘晓瑞, 等.从道教辟谷术论治糖尿病及其并发症.湖南中医药大学学报, 2015, 22(12):43-45.
29.	黄巍, 何清湖, 姚勤.论马王堆医书中的饮食养生理念与方法.湖南中医杂志, 2013, 20(7):6-8.
30.	陈红梅.马王堆医书抄录年代研究概况.中医文献杂志, 2009, 6:50-52.
31.	王娟娟.北京白云观藏明《道藏》洞真部及太玄部医药文献整理研究(研究生论文).北京中医药大学, 2016:1-215.
32.	刘晓瑞, 黄彬洋, 李凯, 等.服饵辟谷养生术防治2型糖尿病的理论初探.时珍国医国药, 2016, 4:907-908.
33.	赵江滨, 刘禹舟.从《伤寒论》阳明病篇看中医养生观.河南中医, 2014, 1:6-7.
34.	刘先勇, 华卫国, 储维忠, 等.辟谷食饵对S-180腹水癌小鼠的影响.山东中医杂志, 2011, 11(5):806-808.
35.	燕晓雯, 郭建红, 俞海虹, 等. 6名辟谷受试者体质量、血压、血糖观察及辟谷养生技术分析.中华中医药杂志, 2016, 29(2):627-629.
36.	洪斌, 王世其, 陇文菊, 等.辟食10天的实证体验及思考.中国保健营养, 2012, 18(4):4187-4188.

1. Freeman JM, Vining EPG. The efficacy of the ketogenic diet 1998:a prospective evaluation of intervention in 150 children. Pediatrics, 1998, 102(4):1358-1363.
2. Kossoff EH, Freeman JM, Turner Z, et al. Ketogenic Diets:treatment for Epilepsy and Other Disorders, 5th edition:New York, DEMOS, 2011:39-48.
3. 廖建湘.生酮饮食疗法的临床方案.中华实用儿科临床杂志, 2013, 28(12):881-883.
4. Wheless JW. History of the ketogenic diet. Epilepsia, 2008, 49(Suppl 8):3-5.
5. Freeman JM, Vining EP. Seizures decrease rapidly after fasting:preliminarystudies of the ketogenic diet. Arch Pediatr Adolesc Med, 1999, 153(9):946-949.
6. 马王堆汉墓帛书整理小组.马王堆汉墓出土医书释文(一), 文物, 1975, 6:1-5.
7. Guelpa G, Marie A.Laluttecontrel epilepsieparlades in toxication etparl are educational imentaire. Rev Ther Medico-Chirurgicale, 1911, 78:8-13.
8. Woodyatt RT. Objects and method of diet adjustment in diabetics. Arch Intern Med, 1921, 28:125-141.
9. Peterman MG. The ketogenic diet in epilepsy. JAMA, 1925, 84:1979-1983.
10. Livingston S. Comprehensive management of epilepsy in infancy, childhood and adolescence. Charles C. Thomas, Springfield, IL, 1972:378-405.
11. Huttenlocher PR. Ketonemia and seizures:metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res, 1976, 10(5):536-540.
12. Liu YM. Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia, 2008, 49 (Suppl 8):33-36.
13. Kossoff EH, Cervenka MC, Henry BJ, et al.A decade of themodified Atkins diet (2003-2013):Results, insights, and future directions.Epilepsy Behav, 2013, 29(3):437-442.
14. Kossoff EH, McGrogan JR, Bluml RM, et al. Amodified Atkins diet is effective for the treatment of intractable pediatricepilepsy. Epilepsia, 2006, 47(2):421-424.
15. Pfeifer HH, Lyczkowski DA, Thiele EA. Low glycemic index treatment:implementation and new insights into efficacy. Epilepsia, 2008, 49(Suppl8):42-45.
16. Larson AM, Pfeifer HH, Thiele EA. Low glycemic index treatment for epilepsy intuberous sclerosis complex. Epilepsy Res, 2012, 99(1-2):180-182.
17. Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet:recommendations of the International Ketogenic Diet Study Group.Epilepsia, 2009, 50(2):304-317.
18. Kossoff EH, Al-Macki N, Cervenka MC, et al. What are theminimum requirements for ketogenic diet services in resource-limited regions?Recommendations from the International League Against Epilepsy Task Force forDietary Therapy. Epilepsia, 2015, 56(9):1337-1342.
19. Kossoff EH, McGrogan JR. Worldwide use of the ketogenic diet. Epilepsia, 2015, 46(10):280-289.
20. Pascual JM, Ronen GM. Glucose Transporter Type I Deficiency (G1D) at 25(1990-2015):presumptions, facts, and the lives of persons with this rare disease. Pediatr Neurol, 2015, 53(5):379-393.
21. Roubergue A, Philibert B, Gautier A, et al. Excellentresponse to a ketogenic diet in a patient with alternating hemiplegia ofchildhood. JIMD Rep, 2015, 15(5):7-12.
22. Allen BG, Bhatia SK, Anderson CM, et al. Ketogenic diets as anadjuvant cancer therapy:history and potential mechanism. Redox Biol, 2014, 2(5):963-970.
23. Spilioti M, Evangeliou AE, Tramma D, et al. Evidence for treatable inborn errors ofmetabolism in a cohort of 187 Greek patients with autism spectrum disorder (ASD).Front Hum Neurosci, 2013, 7(8):858.
24. Cheng CW, Adams GB, Perin L, et al. Prolonged fasting reduces IGF-1/PKA topromote hematopoietic-stem-cell-based regeneration and reverse immunesuppression.Cell Stem Cell, 2014, 14(6):810-823.Erratumin:Cell Stem Cell, 2016, 18(2):291-292.
25. Valadao JM, Vigilante JA, DiGeorge NW, et al. Ketogenic diet for high partial pressure oxygendiving. Undersea Hyperb Med, 2014, 41(4):331-335.
26. Freeman JM, Kossoff EH, Hartman AL.The ketogenic diet:one decade later.Pediatrics, 2007, 119(3):535-543.
27. 李德杏.道教医学辟谷养生术浅析.中华中医药杂志, 2012, 25(5):1230-1232.
28. 王岗, 董调红, 刘晓瑞, 等.从道教辟谷术论治糖尿病及其并发症.湖南中医药大学学报, 2015, 22(12):43-45.
29. 黄巍, 何清湖, 姚勤.论马王堆医书中的饮食养生理念与方法.湖南中医杂志, 2013, 20(7):6-8.
30. 陈红梅.马王堆医书抄录年代研究概况.中医文献杂志, 2009, 6:50-52.
31. 王娟娟.北京白云观藏明《道藏》洞真部及太玄部医药文献整理研究(研究生论文).北京中医药大学, 2016:1-215.
32. 刘晓瑞, 黄彬洋, 李凯, 等.服饵辟谷养生术防治2型糖尿病的理论初探.时珍国医国药, 2016, 4:907-908.
33. 赵江滨, 刘禹舟.从《伤寒论》阳明病篇看中医养生观.河南中医, 2014, 1:6-7.
34. 刘先勇, 华卫国, 储维忠, 等.辟谷食饵对S-180腹水癌小鼠的影响.山东中医杂志, 2011, 11(5):806-808.
35. 燕晓雯, 郭建红, 俞海虹, 等. 6名辟谷受试者体质量、血压、血糖观察及辟谷养生技术分析.中华中医药杂志, 2016, 29(2):627-629.
36. 洪斌, 王世其, 陇文菊, 等.辟食10天的实证体验及思考.中国保健营养, 2012, 18(4):4187-4188.

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