Objective
To study the clinical efficacy of topiramate combined with carbamazepine combined with phenytoin in elderly seizures.
Methods
A total of 105 elderly patients with epilepsy were enrolled in this study from August 2014 to July 2016 in Fuzhou Chinese and Western Medicine Hospital. The patients were aged 61 to 80 years. There were 42 males and 63 females with epilepsy. The course were 1 to 5 years; 55 cases were partial onset, 50 cases were systemic attack. According to the different treatment methods, the patients were divided into A, B, C three groups, each group were 35 patients. Group A was daily treated with 4 to 8 mg/kg topiramate; Group B was treated with 0.3 g carbamazepine combined with 250 to 300 mg phenytoin per day. Group C was daily treated with 4 to 8 mg/kg topiramate and 0.3 g carbamazepine combined with 250 to 300 mg phenytoin. The total effective rate, the incidence of adverse reactions, the number of seizures before and after treatment were compared among the three groups.
Results
The total effective rate of group C was higher than that of group A and B, and the difference was statistically significant (P<0.05). There were no significant differences in the number of epileptic seizures between the three groups before treatment (P>0.05). The number of seizures in group C was significantly lower than that in group A and B (P<0.05).
Conclusions
The treatment of topical epilepsy patients with topiramate and carbamazepine combined with phenytoin can significantly improve the total effective rate of treatment, protect the safety of medication, reduce the number of patients with epilepsy, so that patients can quickly return to normal life. It would be worthy for clinical promotion and use.
Citation：
XU Liqun, WEI Feng. Comparison of topiramate with carbamazepine combined with phenytoin in therapeutic effect of seizures in elderly patients. Journal of Epilepsy, 2018, 4(1): 24-26. doi: 10.7507/2096-0247.20180006
Copy
Copyright © the editorial department of Journal of Epilepsy of West China Medical Publisher. All rights reserved
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- 1. 梁守芳, 袁锋. 托吡酯与卡马西平治疗老年癫痫的疗效比较. 实用中西医结合临床, 2016, 16(6): 34-35.
- 2. 吴正刚. 托吡酯与卡马西平联合治疗脑梗死后继发癫痫疗效对比分析. 临床医药文献电子杂志, 2016, 3(48): 9634-9634.
- 3. 王金莉, 陈杰明, 林合麟, 等. 托吡酯、卡马西平与丙戊酸钠治疗不同类型脑炎继发癫痫疗效观察. 中国实用医刊, 2017, 44(4): 21-23.
- 4. 卓凤萍. 卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫的临床观察. 基层医学论坛, 2017, 21(5): 560-562.
- 5. 宋艳丽. 左乙拉西坦联合卡马西平与托吡酯治疗难治性癫痫合并糖尿病的临床研究. 糖尿病新世界, 2015, 35(6): 45-46.
- 6. 杨优君, 李云华. 加巴喷丁与卡马西平治疗老年原发性三叉神经痛患者的临床疗效观察. 中国生化药物杂志, 2017, 37(2): 229-231.
- 7. 杨丹. 奥卡西平和卡马西平治疗脑卒中后继发性癫痫的疗效对比和康复分析. 中国伤残医学, 2017, 25(1): 49-50.
- 8. 张亚娜. 加巴喷丁与卡马西平治疗原发性三叉神经痛的临床疗效及不良反应观察. 中国卫生标准管理, 2017, 8(3): 75-76.
