Clinical analysis of 20 patients with electrical status epilepticus during sleep_Journal of Epilepsy

Authors：

GAO Jie , WANG Luojun ,  DENG Yanchun

Department of Neurology, Xijing Hospital of Airforce Military Medical School, Xi’an 710032, China;

Corresponding author：

DENG Yanchun, Email: yanchund@fmmu.edu.cn

Keywords：

Epilepsy; ESES; Clinical Research; EEG; Epilepsy Syndrome

DOI：

10.7507/2096-0247.20210063

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To improve the clinicians’ understanding and treatment level of electrical status epilepticus during sleep by analyzing the clinical data of patients with ESES retrospectively.Methods We collected 20 cases from 2018 to 2019 diagnosed in our hospital by clinical and 24-hour video EEG confirmed and analyzed the clinical manifestations, EEG features, seizure type, classification of epilepsy syndrome as well as the imaging findings.Results Among the 20 patients, there were 12 males and 8 females, the mean age was (10.96±2.68) years old, and the first onset age was (8.90±1.93) years old. Epilepsy seizure as the first symptom is most common, the EEG showed a broad or localized sustained discharge, generalized tonic clonic seizure is the main form of seizure type in most patients, ECSWS is the most prominent in the epilepsy syndrome, for small lesion through MR can be found early.Conclusion Most patients have partial or generalized seizures, which have a range of cognitive impairment, mental decline or other issues. It is important to improve the cognitive function, behavior, neuropsychology of patients by long term video EEG monitoring in the early stage.

Citation： GAO Jie, WANG Luojun, DENG Yanchun. Clinical analysis of 20 patients with electrical status epilepticus during sleep. Journal of Epilepsy, 2021, 7(5): 392-396. doi: 10.7507/2096-0247.20210063 Copy

1.	Patry G, Lyagoubi S, Tassinari CA. Subclinical "electrical status epilepticus" induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol, 1971, 24(3): 242-252.
2.	张玮娜, 邹丽萍. 儿童睡眠中癫痫性电持续状态定义病因学及流行病学概述. 中国实用儿科杂志, 2013, 28(2): 81-82.
3.	刘晓燕, 秦炯, 包新华等. 儿童睡眠中癫痫性电持续状态的临床及脑电特征研究. 中国实用儿科杂志, 2000, 15(5): 285-287.
4.	Brazzo D, Pera MC, Fasce M, et al. epileptic encephalopathies with status epilepticus during sleep: new techniques for understanding pathophysiology and therapeutic options. Epilepsy Res Treat, 2012: 642725.
5.	刘晓燕. 儿童睡眠中癫痫性电持续状态的脑电图诊断. 中国实用儿科杂志, 2013, 28(2): 83-85.
6.	曹园园, 彭锋, 王文杰等. Rolandic区放电的27例癫痫患儿长程视频脑电图及临床特征分析. 中华神经医学杂志, 2014, 13(12): 1264-1268.
7.	Guerrini R, Belmonte A, Genton P. Antiepileptic drug-induced worsening of seizures in children. Epilepsia, 1998, 39(Suppl 3): S2-10.
8.	Nikanorova M, Miranda MJ, Atkins M, et al. Ketogenic diet in the treatment of refractory continuous spikes and waves during slow sleep. Epilepsia, 2009, 50(5): 1127-1131.
9.	Kelley SA, Kossoff EH et al. How effective is the ketogenic diet for electrical status epilepticus of sleep? Epilepsy Res, 2016, 127: 339-343.
10.	梁展荣. 睡眠中癫痫性电持续状态的治疗进展. 癫痫与神经电生理学杂志, 2019, 28(1): 44-49.
11.	葛争, 戴园园. 甲泼尼龙冲击疗法对睡眠中癫痫性电持续状态患儿的临床疗效及血清细胞因子的影响. 中南药学, 2020, 18(05): 877-881.
12.	陈静, 杨志仙, 刘晓燕等. 甲泼尼龙冲击治疗对儿童睡眠中癫痫性电持续状态的疗效. 中华儿科杂志, 2014, 52(9): 678-682.
13.	Fainberg N, Harper A, Tchapyjnikov D, et al. Response to immunotherapy in a patient with Landau-Kleffner syndrome and GRIN2A mutation. Epileptic Disord, 2016, 18(1): 97-100.
14.	Geva-Dayan K, Shorer Z, Menascu S, et al. Immunoglobulin treatment for severe childhood epilepsy. ediatr Neurol, 2012, 46(6): 375-381.
15.	Altunel A, Sever A, et al. ACTH has beneficial effects on stuttering in ADHD and ASD patients with ESES: A retrospective study. Brain Dev, 2017, 39(2): 130-137.
16.	李慧, 王华. 甲泼尼龙冲击治疗对儿童睡眠中癫痫性电持续状态免疫功能的影响. 中国小儿急救医学, 2020, 27(2): 119-124.

1. Patry G, Lyagoubi S, Tassinari CA. Subclinical "electrical status epilepticus" induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol, 1971, 24(3): 242-252.
2. 张玮娜, 邹丽萍. 儿童睡眠中癫痫性电持续状态定义病因学及流行病学概述. 中国实用儿科杂志, 2013, 28(2): 81-82.
3. 刘晓燕, 秦炯, 包新华等. 儿童睡眠中癫痫性电持续状态的临床及脑电特征研究. 中国实用儿科杂志, 2000, 15(5): 285-287.
4. Brazzo D, Pera MC, Fasce M, et al. epileptic encephalopathies with status epilepticus during sleep: new techniques for understanding pathophysiology and therapeutic options. Epilepsy Res Treat, 2012: 642725.
5. 刘晓燕. 儿童睡眠中癫痫性电持续状态的脑电图诊断. 中国实用儿科杂志, 2013, 28(2): 83-85.
6. 曹园园, 彭锋, 王文杰等. Rolandic区放电的27例癫痫患儿长程视频脑电图及临床特征分析. 中华神经医学杂志, 2014, 13(12): 1264-1268.
7. Guerrini R, Belmonte A, Genton P. Antiepileptic drug-induced worsening of seizures in children. Epilepsia, 1998, 39(Suppl 3): S2-10.
8. Nikanorova M, Miranda MJ, Atkins M, et al. Ketogenic diet in the treatment of refractory continuous spikes and waves during slow sleep. Epilepsia, 2009, 50(5): 1127-1131.
9. Kelley SA, Kossoff EH et al. How effective is the ketogenic diet for electrical status epilepticus of sleep? Epilepsy Res, 2016, 127: 339-343.
10. 梁展荣. 睡眠中癫痫性电持续状态的治疗进展. 癫痫与神经电生理学杂志, 2019, 28(1): 44-49.
11. 葛争, 戴园园. 甲泼尼龙冲击疗法对睡眠中癫痫性电持续状态患儿的临床疗效及血清细胞因子的影响. 中南药学, 2020, 18(05): 877-881.
12. 陈静, 杨志仙, 刘晓燕等. 甲泼尼龙冲击治疗对儿童睡眠中癫痫性电持续状态的疗效. 中华儿科杂志, 2014, 52(9): 678-682.
13. Fainberg N, Harper A, Tchapyjnikov D, et al. Response to immunotherapy in a patient with Landau-Kleffner syndrome and GRIN2A mutation. Epileptic Disord, 2016, 18(1): 97-100.
14. Geva-Dayan K, Shorer Z, Menascu S, et al. Immunoglobulin treatment for severe childhood epilepsy. ediatr Neurol, 2012, 46(6): 375-381.
15. Altunel A, Sever A, et al. ACTH has beneficial effects on stuttering in ADHD and ASD patients with ESES: A retrospective study. Brain Dev, 2017, 39(2): 130-137.
16. 李慧, 王华. 甲泼尼龙冲击治疗对儿童睡眠中癫痫性电持续状态免疫功能的影响. 中国小儿急救医学, 2020, 27(2): 119-124.

Previous Article
Efficacy and safety of adjunctive perampanel in children with refractory epilepsy
Next Article
A preliminary investigation of adenoid hypertrophy in children with epilepsy

Journal of Epilepsy

Clinical analysis of 20 patients with electrical status epilepticus during sleep

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content