Clinical study on the treatment of refractory epilepsy in children by adding Chinese medicine_Journal of Epilepsy

Authors：

YAO Yanyang ¹ , ZHANG Jingwen ² , CHEN Zhihong ^1,2 ,  ZHAI Qiongxiang ² , SHI Gang’an ³ , LI Xueping ⁴

1. Department of Neurology, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou 519041, China;
2. Department of Neurology, Guangdong Provincial People's Hospital, Guangzhou 519041, China;
3. School of Medicine, South China University of Teconology, Guangzhou 511400, China;
4. Department of Neurology, Foshan Maternal and Child Health Care Hospital, Foshan 528000, China;

Corresponding author：

ZHAI Qiongxiang, Email: zhaiqiongxiang@sina.com

Keywords：

Xiao’er kang xian capsule; Refractory epilepsy; Neuron specific enolase; Cludter of differentiation19⁺

DOI：

10.7507/2096-0247.202502015

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the clinical efficacy of Xiao’er kang xian capsule added to anti-seizure medications (ASMs) in the treatment of children with refractory epilepsy and its influence on serum neuron-specific enolase (NSE) and cludter of differentiation 19⁺ (CD19⁺) levels. Methods A total of 60 children with refractory epilepsy were selected from the pediatric outpatient department and ward of Guangdong Provincial People's Hospital from February 2021 to June 2023. The study subjects were divided into two groups by numerical random method,with 30 cases in each group. The children with Xiao’er kang xian capsule added to the original treatment were the treatment group and the children without Xiao’er kang xian capsule added to the original treatment were the control group. The frequency, duration, EEG characteristics, adverse reactions and changes in serum NSE and CD19⁺ levels of the two groups were compared after treatment. Results Self-control before and after treatment in the treatment group: the frequency and duration of seizures were significantly reduced, with statistical difference (P<0.05). EEG discharge index in awake period and sleep period were significantly decreased, with statistical difference (P<0.05). After 6 months of treatment, comparison between the two groups of children: the seizure frequency of children in the treatment group was significantly decreased compared with the control group (P=0.03). There was a statistical difference (P<0.05), and the seizure duration in the treatment group was less than that in the control group (P=0.863), the clinical effective rate of treatment group 83.33% was higher than that of control group 63.33% (P=0.08), the effective rate of EEG in treatment group 80% was higher than that of control group 60% (P=0.091), serum NSE and CD19⁺ in treatment group were lower than that of control group, with no statistical difference (P>0.05). After 12 months of treatment, the frequency and duration of seizures in the treatment group were significantly decreased (P<0.05). The clinical efficacy and effectiveness of treatment group were significantly higher than that of control group (P=0.038). The incidence of adverse reactions in both groups was 16.67% (P>0.05). The effective rate of EEG in treatment group was significantly higher than that in control group (P=0.053). Serum NSE and CD19⁺ in treatment group were significantly lower than those in control group (P<0.05). Conclusion For children with refractory epilepsy, the addition of Xiao’er kang xian capsule on the basis of the original treatment has obvious effect low adverse reaction and high safety. NSE and CD19⁺ can be used as monitoring indicators for the influence of the disease and prognosis evaluation during the treatment of children with epilepsy.

Citation： YAO Yanyang, ZHANG Jingwen, CHEN Zhihong, ZHAI Qiongxiang, SHI Gang’an, LI Xueping. Clinical study on the treatment of refractory epilepsy in children by adding Chinese medicine. Journal of Epilepsy, 2025, 11(3): 214-219. doi: 10.7507/2096-0247.202502015 Copy

1.	中国抗癫痫协会. 临床诊疗指南: 癫痫病分册. 北京: 人民卫生出版社, 2023.
2.	Song L, Liu F, Liu Y, et al. Clonazepam add-on therapy for refractory epilepsy in adults and children. Cochrane Database Syst Rev, 2018, 5(5): CD01 2253.
3.	张宇昕, 翟琼香, 汤志鸿, 等. 左乙拉西坦添加治疗小儿额叶癫痫: 附 105 例报告. 南方医科大学学报, 2014, 34(3): 364-367.
4.	郑筱萸. 中药新药临床研究指导原则: 试行. 北京: 中国医药科技出版社, 2002.
5.	马融, 李新民, 张德芹, 等. 小儿抗痫胶囊治疗儿童癫痫及其神经生化机制的研究. 医学研究杂志, 2 006, 35(9): 39-40.
6.	钱悠悠. 拉莫三嗪联合小剂量丙戊酸钠治疗初诊癫痫的疗效及对神经认知功能的影响. 实用临床医药杂志, 2020, 24(2): 80-82,86.
7.	Rigo JM, Hans G, Nguyen L, et al. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. BriT J Pharmacol, 2002, 136(5): 659-672.
8.	Preuss RGWT. OxcarbazepineIn: Stat Pearls. Treasure Island (FL): StatPearls Publishing, 2022.
9.	彭梦婕, 邹建华. Development of overseas Chinese medicine and legislative status. World Journal of Integrated Traditional and Western Medicine, 2022, 5(6): 24-33.
10.	孙秋玲, 申兴田, 董争清, 等. 小儿抗痫胶囊联合左乙拉西坦治疗小儿癫痫伴智力低下疗效及血清瘦素、白细胞介素6和胰岛素样生长因子1的影响. 实验与检验医学, 2019, 37(5): 944-947.
11.	卢俞任, 毛中臣. 小儿抗痫胶囊联合奥卡西平治疗小儿癫痫的疗效观察. 药物评价研究, 2020, 43(2): 277-282.
12.	耿丽娟, 王葆辉, 张现娥, 等. 小儿抗痫胶囊联合丙戊酸钠治疗儿童原发性全身强直– 阵挛发作型癫痫的临床研究及其对GFAP、S100β水平的影响. 现代药物与临床, 2021, 36(5): 995-999.
13.	郭娜, 马英, 王琳莹, 等. 脑卒中患者血清 Hcy及NSE水平与癫痫发作的相关性研究. 现代检验医学杂志, 2022, 37(1): 177-181.
14.	黎素清, 郑凤丽, 谭志军, 等. 癫痫患儿血清及脑脊液 CRP、S100β、NSE 含量变化与临床意义. 现代医学与健康研究, 2020, 4(5): 84-85.
15.	ZhaoYL , Li JM, Fan Y, et al. Sodium valproate combined with levetiracetam in pediatric epilepsy and its influence on NSE, IL6, hsCRP and electroencephalogram improvement. Experimental And Therapeutic Medicine, 2020, 20: 2043-2048.
16.	Mu RZ, Liu S, Liang KG, et al. A meta-analysis of neuron-specifific enolase levels in cerebrospinal fluid and serum in children with epilepsy. Front Mol Neurosci, 2020, 10(13): 24.
17.	Hanak TJ, Libbey JE, Doty DJ, et al. Positive modulation of m GluR5 attenuates seizures and reduces TNF-a+macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy. Exp l Neuro1, 2019, 311: 194-204.
18.	黄永洪, 康颖, 韩登科, 等. 125例癫痫患儿外周血B淋巴细胞、NK 细胞和NKT 细胞的检测与分析. 国际检验医学杂志, 2017, 38(27): 3286-3290.
19.	黎雪萍, 陈志红. 小儿癫痫外周血淋巴细胞亚群水平的变化及其意义. 汕头大学医学院, 硕士学位论文, 2022.

1. 中国抗癫痫协会. 临床诊疗指南: 癫痫病分册. 北京: 人民卫生出版社, 2023.
2. Song L, Liu F, Liu Y, et al. Clonazepam add-on therapy for refractory epilepsy in adults and children. Cochrane Database Syst Rev, 2018, 5(5): CD01 2253.
3. 张宇昕, 翟琼香, 汤志鸿, 等. 左乙拉西坦添加治疗小儿额叶癫痫: 附 105 例报告. 南方医科大学学报, 2014, 34(3): 364-367.
4. 郑筱萸. 中药新药临床研究指导原则: 试行. 北京: 中国医药科技出版社, 2002.
5. 马融, 李新民, 张德芹, 等. 小儿抗痫胶囊治疗儿童癫痫及其神经生化机制的研究. 医学研究杂志, 2 006, 35(9): 39-40.
6. 钱悠悠. 拉莫三嗪联合小剂量丙戊酸钠治疗初诊癫痫的疗效及对神经认知功能的影响. 实用临床医药杂志, 2020, 24(2): 80-82,86.
7. Rigo JM, Hans G, Nguyen L, et al. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. BriT J Pharmacol, 2002, 136(5): 659-672.
8. Preuss RGWT. OxcarbazepineIn: Stat Pearls. Treasure Island (FL): StatPearls Publishing, 2022.
9. 彭梦婕, 邹建华. Development of overseas Chinese medicine and legislative status. World Journal of Integrated Traditional and Western Medicine, 2022, 5(6): 24-33.
10. 孙秋玲, 申兴田, 董争清, 等. 小儿抗痫胶囊联合左乙拉西坦治疗小儿癫痫伴智力低下疗效及血清瘦素、白细胞介素6和胰岛素样生长因子1的影响. 实验与检验医学, 2019, 37(5): 944-947.
11. 卢俞任, 毛中臣. 小儿抗痫胶囊联合奥卡西平治疗小儿癫痫的疗效观察. 药物评价研究, 2020, 43(2): 277-282.
12. 耿丽娟, 王葆辉, 张现娥, 等. 小儿抗痫胶囊联合丙戊酸钠治疗儿童原发性全身强直– 阵挛发作型癫痫的临床研究及其对GFAP、S100β水平的影响. 现代药物与临床, 2021, 36(5): 995-999.
13. 郭娜, 马英, 王琳莹, 等. 脑卒中患者血清 Hcy及NSE水平与癫痫发作的相关性研究. 现代检验医学杂志, 2022, 37(1): 177-181.
14. 黎素清, 郑凤丽, 谭志军, 等. 癫痫患儿血清及脑脊液 CRP、S100β、NSE 含量变化与临床意义. 现代医学与健康研究, 2020, 4(5): 84-85.
15. ZhaoYL , Li JM, Fan Y, et al. Sodium valproate combined with levetiracetam in pediatric epilepsy and its influence on NSE, IL6, hsCRP and electroencephalogram improvement. Experimental And Therapeutic Medicine, 2020, 20: 2043-2048.
16. Mu RZ, Liu S, Liang KG, et al. A meta-analysis of neuron-specifific enolase levels in cerebrospinal fluid and serum in children with epilepsy. Front Mol Neurosci, 2020, 10(13): 24.
17. Hanak TJ, Libbey JE, Doty DJ, et al. Positive modulation of m GluR5 attenuates seizures and reduces TNF-a+macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy. Exp l Neuro1, 2019, 311: 194-204.
18. 黄永洪, 康颖, 韩登科, 等. 125例癫痫患儿外周血B淋巴细胞、NK 细胞和NKT 细胞的检测与分析. 国际检验医学杂志, 2017, 38(27): 3286-3290.
19. 黎雪萍, 陈志红. 小儿癫痫外周血淋巴细胞亚群水平的变化及其意义. 汕头大学医学院, 硕士学位论文, 2022.

Journal of Epilepsy

Clinical study on the treatment of refractory epilepsy in children by adding Chinese medicine

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content