The expression and rearrangement of bcl-2 gene in 64 cases with colorectal carcinoma were studied by immunohistochemical technique and semi-nest PCR respectively. The results showed the abnormal changes of the expression and rearrangement of bcl-2 gene had emerged in the early stage of colorectal carcinoma. The tumors with the expression of bcl-2 were associated with a higher incidence of metastasis to lymphatic node. The rearragement of bcl-2 was significantly higher in late-stage than that in early-stage. These suggest that bcl-2 gene involves in the regulation of the development of colorectal carcinoma. The state of the changes of bcl-2 gene in colorectal carcinoma may predict the therapeutic effect and prognosis of colorectal carcinoma.
Citation：
Luo Chenyu,Li Shiyong.. A STUDY ON THE EXPRESSION AND REARRANGEMENT OF BCL-2 GENE IN COLORECTAL CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(1): 4-6. doi:
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- 1. Leek RD, Kaklamanis L, Pezzela F, et al. bcl2 in normal human breast and carcinoma,association with oestrogen receptorpositive, epidermal growth factor receptornegative tumors and in situ cancer. Br J Cancer, 1994; 69(1)∶135.
- 2. 骆成玉， 詹新恩， 姜军. 乳腺癌组织中T细胞亚群分布的观察与分析. 中华实验外科杂志， 1992； 9(增刊)∶219.
- 3. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: laboratory manuals. 2th ed. New York: Cold Spring Harbor Laboratory Press, 1989∶463-493.
- 4. Yuan R, Dowling P, Zucca E, et al. Detection of bcl2/JH rearrangement in follicular and diffuse lymphoma: concordant results of peripheral blood and bone marrow analysis at diagnosis. Br J Cancer, 1993; 67(5)∶922.
- 5. Hsu B, Marin MC, Brisbay S, et al. Expression of bcl2 gene confers multidrug resistance to chemotherapyinduced cell death. Cancer Bull, 1994; 46(1)∶125.
- 6. Fisher TC, Milner AE, Gregory CD, et al. Bcl2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res, 1993; 53(15)∶3321.
