To evaluate effect of recombinant human growth hormone (rhGH) on immunologic function in patients with gastrointestinal malignant tumor (GIMT). Before and 3 weeks after surgical treatment and administration of rhGH, the amount of T lymphocyte subset (T-LS) and soluble interleukin 2 receptor (sIL-2R) level were measured in 12 patients with GIMT, which were compared with 20 cases of normal control and 18 cases of GIMT treated by surgery alone. Result: ①In all GIMT patients, the serum CD＋3, CD＋4 level and the ratio of CD＋4/CD＋8 were lower than normal control and the sIL2R level was much higher; ②After operation, the serum CD＋3, CD＋4 level and the ratio of CD＋4/CD＋8 of all patients increased, the serum sIL2R level decreased; ③In patients recieved rhGH, the serum CD＋3, CD＋4 level and the ratio of CD＋4/CD＋8 were much more increased and the serum sIL-2R level much more decreased than those of surgery alone group. Conclusion: rhGH can enhance the immunologic function of patients with GIMT.
Citation：
Ran Jianghua,Guo Qun,Zhang Jiahua,et al.. EFFECT OF RECOMBINANT HUMAN GROWTH HORMONE ON IMMUNOLOGIC FUNCTION IN PATIENTS WITH GASTROINTESTINAL MALIGNANT TUMOR. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 298-299. doi:
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| 1. |
曹雪涛. 细胞因子研究的现状与发展趋势. 中国肿瘤生物治疗杂志， 1995； 3(2)∶175.
|
| 2. |
李求是. 肿瘤患者手术前后T细胞亚群细胞毒性细胞因子及血浆抑制因子变化. 中国免疫学杂志， 1992； 8(4)∶247.
|
| 3. |
Lotze MT, Finn OJ. Recent advances incellular immunolgy: implications for immunity to cancer. Immunol Today, 1990; 11(6)∶190.
|
| 4. |
Laurencea A, Rubin MD, David L, et al. The soluble interleukin2 receptor biology, function and dinical application. Intern Med, 1990; 113(8)∶619.
|
| 5. |
Semenzato C, Foa R, Agostioni C, et al. High serum levels of soluble interleukin 2 receptor in patients with B chronic lympherytic leukemia. Blood, 1987; 70∶369.
|
| 6. |
Saito H, Fukatsu K, Ming Tsan L, et al. Growth hormone and the immune ressponse to bacterial infection. Horm Res, 1996; 45∶50.
|
| 7. |
Vara Thorbeck R, Guerrero JA, Rosell J, et al. Exogenous growth hormone: effects on the cateabobic response to surgically produced acute stress and on postoperative immune function. World J Surg, 1993; 17(4)∶530.
|
| 8. |
顾军，黎介寿， 李维勤等. 重组生长激素对严重感染后蛋白质代谢影响的研究. 中华外科杂志， 1997； 35(2)∶104.
|
| 9. |
何桂珍， 蒋朱明. 重组生长激素对创伤后代谢的影响. 中华医学杂志， 1995； 75(5)∶312.
|
| 10. |
蒋朱明， 何桂珍， 张思源等. 手术后患者用生长激素及肠外营养的代谢效应. 中华外科杂志， 1995； 33(11)∶704.
|
- 1. 曹雪涛. 细胞因子研究的现状与发展趋势. 中国肿瘤生物治疗杂志， 1995； 3(2)∶175.
- 2. 李求是. 肿瘤患者手术前后T细胞亚群细胞毒性细胞因子及血浆抑制因子变化. 中国免疫学杂志， 1992； 8(4)∶247.
- 3. Lotze MT, Finn OJ. Recent advances incellular immunolgy: implications for immunity to cancer. Immunol Today, 1990; 11(6)∶190.
- 4. Laurencea A, Rubin MD, David L, et al. The soluble interleukin2 receptor biology, function and dinical application. Intern Med, 1990; 113(8)∶619.
- 5. Semenzato C, Foa R, Agostioni C, et al. High serum levels of soluble interleukin 2 receptor in patients with B chronic lympherytic leukemia. Blood, 1987; 70∶369.
- 6. Saito H, Fukatsu K, Ming Tsan L, et al. Growth hormone and the immune ressponse to bacterial infection. Horm Res, 1996; 45∶50.
- 7. Vara Thorbeck R, Guerrero JA, Rosell J, et al. Exogenous growth hormone: effects on the cateabobic response to surgically produced acute stress and on postoperative immune function. World J Surg, 1993; 17(4)∶530.
- 8. 顾军，黎介寿， 李维勤等. 重组生长激素对严重感染后蛋白质代谢影响的研究. 中华外科杂志， 1997； 35(2)∶104.
- 9. 何桂珍， 蒋朱明. 重组生长激素对创伤后代谢的影响. 中华医学杂志， 1995； 75(5)∶312.
- 10. 蒋朱明， 何桂珍， 张思源等. 手术后患者用生长激素及肠外营养的代谢效应. 中华外科杂志， 1995； 33(11)∶704.
