Expression of bcl-2 in 45 cases of primary gallbladder carcinomas and 39 cases of gallbladder adenomas were detected by streptavidin-biotin-peroxidase complex (SABC) methods. The results revealed that the positive rate of bcl-2 in primary gallbladder carcinomas was 71.1% and that in gallbladder adenomas was 87.2%, there was no obvious difference between them (Ｐ＞0.05). Expression of bcl-2 in well, moderately and poorly differentiated primary gallbladder carcinomas were 82.8%, 82.4% and 50.0% respectively with significant statistical difference (Ｐ＜0.01). The positive rate of bcl-2 in stages Ⅰ,Ⅱ and Ⅲ of primary gallbladder carcinomas were 81.3% and 55.2% respectively with no significant differnce. The result suggests that expression of bcl-2 in primary gallbladder carcinomas has no correlation with clinic stages.
Citation：
Xu Hongyong,Wang Wenyong,Yan Qingguo,et al.. EXPRESSION AND SIGNIFICANCE OF ANTIAPOPTOSIS GENE BCL-2 IN PRIMARY GALLBLADDER CARCINOMAS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(2): 73-74. doi:
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| 1. |
Tsujimoto Y, Finger LR, Yunis J, et al. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14∶18) chromosome translocation. Science, 1984; 226(4678)∶1097.
|
| 2. |
Frank AS, San Bao R, Karen RC, et al. bcl2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Research, 1995; 55(2)∶237.
|
| 3. |
徐宏勇，阎庆国，方驰华等. 凋亡相关基因bcl2和bax在结肠肿瘤的表达及意义. 天津医药， 1997； 25(8)∶459.
|
| 4. |
Shi SR, Key ME, Kalra KL. Antigen retrieval in formalin fixed paraffin embeded tissues: an enbancement method for immunohistochemical staining based upon microwave oven heating of tissue sections. J Histochem Cytochem, 1991; 39(6)∶741.
|
| 5. |
Hino N, Higashi T, Nouso K, et al. Apoptosis and proliferation of human hepatocellular carcinoma. Liver, 1996; 16(3)∶123.
|
| 6. |
Hellemans P, Van Dam PA, Weiler J, et al. Prognostic value of bcl2 expression in invasive breast cancer. Br J Cancer, 1995; 72(2)∶354.
|
| 7. |
Henriksen R, Willander E, Berg K. Expression and prognostic significance of bcl2 in ovarian tumors. Br J Cancer, 1995; 72(10)∶1324.
|
| 8. |
Viale G, Roncalli M, Grimelius L, et al. Prognostic value of bcl2 immunoreactivity in medullary thyroid carcinoma. Human patho, 1995; 26(9)∶945.
|
| 9. |
Lauwers GY, Scott GV, Karpeh MS. Immunohistechemical evaluation of bcl2 protein expression in gastric adenocarcinomas. Cancer, 1995; 75(9)∶2209.
|
- 1. Tsujimoto Y, Finger LR, Yunis J, et al. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14∶18) chromosome translocation. Science, 1984; 226(4678)∶1097.
- 2. Frank AS, San Bao R, Karen RC, et al. bcl2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Research, 1995; 55(2)∶237.
- 3. 徐宏勇，阎庆国，方驰华等. 凋亡相关基因bcl2和bax在结肠肿瘤的表达及意义. 天津医药， 1997； 25(8)∶459.
- 4. Shi SR, Key ME, Kalra KL. Antigen retrieval in formalin fixed paraffin embeded tissues: an enbancement method for immunohistochemical staining based upon microwave oven heating of tissue sections. J Histochem Cytochem, 1991; 39(6)∶741.
- 5. Hino N, Higashi T, Nouso K, et al. Apoptosis and proliferation of human hepatocellular carcinoma. Liver, 1996; 16(3)∶123.
- 6. Hellemans P, Van Dam PA, Weiler J, et al. Prognostic value of bcl2 expression in invasive breast cancer. Br J Cancer, 1995; 72(2)∶354.
- 7. Henriksen R, Willander E, Berg K. Expression and prognostic significance of bcl2 in ovarian tumors. Br J Cancer, 1995; 72(10)∶1324.
- 8. Viale G, Roncalli M, Grimelius L, et al. Prognostic value of bcl2 immunoreactivity in medullary thyroid carcinoma. Human patho, 1995; 26(9)∶945.
- 9. Lauwers GY, Scott GV, Karpeh MS. Immunohistechemical evaluation of bcl2 protein expression in gastric adenocarcinomas. Cancer, 1995; 75(9)∶2209.
