To study the prognostic significance of proliferative cell nuclear antigen(PCNA)in bile duct carcinoma,expression of PCNA protein was studied immunohistochemically in 30 patients with bile duct carcinoma.Results:86.7 percent of bile duct carcinomas showed PCNA positive staining and significiant difference was observed between malignant and benign tissues.These results suggest that proliferative activity of malignant tissues was ber than that of the benign ones.In patients with cancer of stages 3,the mean survial time for those with high proliferative activity was 13 months in constrast with 26 months for those with low activity.PCNA is of prognostic significance for bile duct carcinoma patients.
Citation：
Xu Chunsen,Yin Fengzhi,Chen Daliang.. THE PORGANSTIC SIGNIFICANCE OF PROLIFERATIVE CELL NUCLEAR ANTIGEN PROTEIN IN BILE DUCT CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(2): 81-82. doi:
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Hall PA,Levison DA,Woodst AL,et al.PCNA immunolocalization in paraffin sections,an index of cell proliferation with evidence of deregulated expression insome neoplasmes.J Pathol,1990;162(4):285.
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Thomas M,Noguchi M,Kitagawa H,et al.Poor prognostic value of proliferating cell nuclear antigen labelling index in breast carcinoma.J Clin Pathol,1993;46(6):525.
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Donald EH,Jorge AS,Donald C,et al.Carcinoma of the extrahepatic bile ducts,histological types,stage of disease,grade and survival rates.Cancer,1992;70(6):1498.
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Miyachi K,Fritzer MJ,Tan EM,et al.Autoantibody to a nuclear antigen in proliferating cells.J Immunol,1978;121(6):2228.
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- 1. Hall PA,Levison DA,Woodst AL,et al.PCNA immunolocalization in paraffin sections,an index of cell proliferation with evidence of deregulated expression insome neoplasmes.J Pathol,1990;162(4):285.
- 2. Thomas M,Noguchi M,Kitagawa H,et al.Poor prognostic value of proliferating cell nuclear antigen labelling index in breast carcinoma.J Clin Pathol,1993;46(6):525.
- 3. Donald EH,Jorge AS,Donald C,et al.Carcinoma of the extrahepatic bile ducts,histological types,stage of disease,grade and survival rates.Cancer,1992;70(6):1498.
- 4. Miyachi K,Fritzer MJ,Tan EM,et al.Autoantibody to a nuclear antigen in proliferating cells.J Immunol,1978;121(6):2228.
