负压引流技术在临床应用中的研究进展_West China Medical Journal

Authors：

李晨阳 ¹ ,  马兵 ²

Corresponding author：

马兵, Email: mrtianpinlee@yahoo.com.cn

Keywords：

负压引流技术; 临床应用

Video：

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【摘要】　负压引流技术作为一种促进创面愈合的有效治疗手段，目前越来越多的应用于临床各类难愈性创面的治疗工作中。现就负压引流技术的作用机制、适应证、禁忌证及疗效影响因素等方面进行了综述。

Citation： 李晨阳,马兵. 负压引流技术在临床应用中的研究进展. West China Medical Journal, 2011, 26(10): 1461-1465. doi: Copy

1.	Argenta LC, Morykwas MJ, Marks MW, et al.Vacuum-assistied closure: state of clinic art[J]. Plast Reconstr Surg, 2006, 117(7): 127-142.
2.	Armstrong DG, Lavery LA. Nagative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial[J]. Lancet, 2005, 366(9498): 1704-1710.
3.	Morykwas MJ, Argenta LC, Shelton-Brown EI, et al. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation[J]. Ann Plast Surg, 1997, 38(6): 553.
4.	Petzina R, Gustafsson L, Mokhtari A, et al. Effect of vacuum-assisted closure on blood flow in the peristernal thoracic wall afterinternal mammary artery harvesting[J]. Eur J Cardiothorac Surg, 2006, 30(1): 85-89.
5.	Chen SZ, Li J, Lin XY. Effects of vacuum-assisted closure on wound microcirculation: an experimental study[J]. Asian J Surg, 2005, 28(3): 211-217.
6.	Fleischmann W, Strecher W, Bombelli M.Vacuum sealing as treatment of soft damage in open fractures[J].Unfallchirurg, 1993, 96(9): 488-492.
7.	吕小星, 陈绍宗, 李学拥, 等. 封闭负压引流技术对创周组织水肿及血管通透性的影响[J]. 中国临床康复, 2003, 7(3): 1244-1245.
8.	Ladwig GP, Robson MC, Liu R, et al. Ratios of activated MMP-9/TIMP-1 in wound fluids are inverse correlated with healing of pressure ulscers[J]. Wound Repair Regen, 2002, 10(10): 26-37.
9.	石冰, 陈绍宗, 张萍, 等. 封闭负压引流技术对人肉芽创面中MMP-1、MMP-2、MMP-13 mRNA表达的影响[J]. 中华整形外科杂志, 2003, 19(4): 279-281.
10.	Squier CA.The stretching of mouse skin in vivo: effect on epidermal proliferation and thickness[J].J Invest Dermato, 1980, 74(2): 68-71.
11.	Cozart RF, Atchison JR, Lett ED, et al. The use of controlled subatmospheric pressure to promote wound healing in preparation for split-thickness skin grafting in a fourth degree burn[J]. Tenn Med, 1999, 92(10): 382-384.
12.	Nakazawa T, Yasuhara H, Shigematsu K, et al. Smooth muscle cell migration induced by shear-loaded platelets and endothelial cells.Enhanced PDGF Production by shear-loaded platelets[J]. Int angiol, 2000, 19(2): 142-146.
13.	Saxena V, Hwang CW, Huang S, et al.Vacuum-assisted closure: micro deformations of wounds and cell proliferation[J].Plast Reconstr Surg, 2004, 114(5): 1086-1096.
14.	Kilpadi D, Bower CE, Reade CC. Effect of vacuum-assisted closure therapy on early systemic cytokine levels in a swine model[J]. Wound Rep Reg, 2006, 14(2): 210-215.
15.	江苏阳, 陈绍宗, 胡绍华, 等. 封闭式负压引流技术对大鼠创面愈合过程中VEGF和Bcl的影响[J]. 中国美容医学, 2003, 12(2): 142-146.
16.	Moran SG, Windham ST, Cross JM, et al. Vacuum-assisted complex wound closure with elastic vessel loop augmentation. A novel technique[J]. J Wound Care, 2003, 12(6): 212-213.
17.	Younan G, Ogawa R, Ramirez M, et al. A nalysis of nerve and neuropeptide patterns in vacuum-assisted closure-treated diabetic murine wound[J]. Plast Reconstr Surg, 2010, 126(1): 87-96.
18.	Saaiq M, Hameed-Ud-Din, Khan MI, et al. Vacuum-assisted closure therapy as a pretreatment for split thickness skin graft[J]. J Coll Physicians Surg Pak, 2010, 20(10): 675-679.
19.	周业平, 田鹏, 于东宁, 等. 41例胸骨骨髓炎的外科综合治疗[J]. 中华损伤与修复杂志, 2010, 5(3): 16-18.
20.	Scholl L, Chang E, Reitz B, et al. Sternal osteomyelitis: use of vacuum-assisted closure device as an adjunct to definitive closure with sternectomy and muscle flap reconstruction[J]. Arch Orthop Trauma Surg, 2004, 19(5): 453-461.
21.	Nakayama M. Applying negative pressure therapy to deep pressure ulcers covered by soft necrotic tissue[J]. Int Wound J, 2010, 7(3): 160-166.
22.	黄雄飞, 杜靖远. 封闭式负压引流治疗开放性骨折合并软组织缺损[J]. 中华创伤杂志, 1998, 14(3): 183.
23.	马丹, 刘敏, 马兵, 等. VSD在5·12地震伤员下肢挤压伤后骨筋膜间隙综合征中的应用[J]. 重庆医学, 2009, 38(2): 150-151.
24.	Whitehead SJ, Forest-Bendien VL, Richard JL, et al. Economic evaluation of vacuum assisted closure therapy for the treatment of diabetic foot ulcers in France[J]. Int Wound J, 2010, 8(1): 22-32.
25.	Stansby G, Wealleans V, Wilson L, et al. Clinical experience of a new NPWT system in diabetic foot ulcers and post-amputation wounds[J]. J Wound Care, 2010, 19(11): 496, 498-502.
26.	Nather A, Chionh SB, Han AY, et al. Effectiveness of vacuum-assisted closure (VAC) therapy in the healing of chronic diabetic foot ulcers[J]. Ann Acad Med Singapore, 2010, 39(5): 353-358.
27.	Rispoli DM, Horne BR, Kryzak TJ, et al. Description of a technique for vacuum-assisted deep drains in the management of cavitary defects and deep infections in devastating military and civilian trauma[J]. J Trauma, 2010, 68(5): 1247-1252.
28.	李荣刚, 刘兴炎. MRI与病理学评价封闭式负压引流技术早期治疗肢体枪弹伤疗效[J].中国修复重建外科杂志, 2010, 24(3): 335-339.
29.	陈炯, 周建军, 苏国亮, 等. 早期负压封闭引流治疗深II度烧伤创面的临床疗效评价[J].中华烧伤杂志, 2010, 26(3): 170-174.
30.	Topaz M, Bisker O, Litmanovitch M, et al. Application of regulated oxygen-enriched negative pressure-assited wound therapy in combating anaerobic infections[J]. Eur J Plast Surg, DOI 10.1007/s00238-010-0514-5.
31.	Citak M, Backhaus M, Meindl R, et al. Rear complication after VAC-therapy in the treatment of deep sore ulcers in a paraplegic patient[J]. Arch Orthop Trauma Surg, 2010, 130(12): 1511-1514.
32.	Hourigan LA, Linfoot JA, Chung KK, et al. Loss of protein, immunoglobulins, and electrolytes in exudates from negative pressure wound therapy[J]. Nutr Clin Pract, 2010, 25(5): 510-516.
33.	Ho CH, Powell HL, Collins JF, et al. Poor nutrition is a relative contraindication to negative pressure wound therapy for pressure ulcers: preliminary observations in patients with spinal cord injury[J]. Adv Skin Wound Care, 2010, 23(11): 508-516.
34.	李婧, 陈绍宗. 封闭负压引流技术对创面微循环流速和血管口径影响的实验研究[J]. 现代康复, 2000, 4(12): 1848-1849.
35.	Borgquist O, Ingemansson R, Malmsjö M, et al. Wound edge microvascular blood flow during negative-pressure wound therapy: examining the effects of pressure from-10 to-175 mm Hg[J]. Plast Reconstr Surg, 2010, 125(2): 502-509.
36.	Malmsjö M, Lindstedt S, Inqemansson R, et al. Influence on pressure transduction when using different drainage techniques and wound fillers (foam and gauze) for negative pressure wound therapy[J]. Int Wound J, 2010, 7(5): 406-412.
37.	Hurd T, Chadwick P, Cote J, et al. Impact of gauze-based NPWT on the patient and nursing experience in the treatment of challenging wounds[J]. Int Wound J, 2010, 7(6): 448-455.
38.	Scimeca CL, Bharara M, Fisher TK, et al. Novel use of insulin in continuous-instillation negative pressure wound therapy as “wound chemotherapy” [J]. J Diabetes Sci Technol, 2010, 4(4): 820-824.
39.	Scimeca CL, Bharara M, Fisher TK, et al. Novel use of doxycycline in continuous-instillation negative pressure wound therapy as “wound chemotherapy” [J]. Foot Ankle Spec, 2010, 3(4): 190-193.
40.	Franczyk M, Lohman RF, Aqarwal JP, et al. The impact of topical lidocaine on pain level assessment during and after vacuum-assisted closure dressing changes: a double-blind, prospective, randomized study[J]. Plast Reconstr Surg, 2009, 124(3): 854-861.

1. 　Argenta LC, Morykwas MJ, Marks MW, et al.Vacuum-assistied closure: state of clinic art[J]. Plast Reconstr Surg, 2006, 117(7): 127-142.
2. 　Armstrong DG, Lavery LA. Nagative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial[J]. Lancet, 2005, 366(9498): 1704-1710.
3. 　Morykwas MJ, Argenta LC, Shelton-Brown EI, et al. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation[J]. Ann Plast Surg, 1997, 38(6): 553.
4. 　Petzina R, Gustafsson L, Mokhtari A, et al. Effect of vacuum-assisted closure on blood flow in the peristernal thoracic wall afterinternal mammary artery harvesting[J]. Eur J Cardiothorac Surg, 2006, 30(1): 85-89.
5. 　Chen SZ, Li J, Lin XY. Effects of vacuum-assisted closure on wound microcirculation: an experimental study[J]. Asian J Surg, 2005, 28(3): 211-217.
6. 　Fleischmann W, Strecher W, Bombelli M.Vacuum sealing as treatment of soft damage in open fractures[J].Unfallchirurg, 1993, 96(9): 488-492.
7. 　吕小星, 陈绍宗, 李学拥, 等. 封闭负压引流技术对创周组织水肿及血管通透性的影响[J]. 中国临床康复, 2003, 7(3): 1244-1245.
8. 　Ladwig GP, Robson MC, Liu R, et al. Ratios of activated MMP-9/TIMP-1 in wound fluids are inverse correlated with healing of pressure ulscers[J]. Wound Repair Regen, 2002, 10(10): 26-37.
9. 　石冰, 陈绍宗, 张萍, 等. 封闭负压引流技术对人肉芽创面中MMP-1、MMP-2、MMP-13 mRNA表达的影响[J]. 中华整形外科杂志, 2003, 19(4): 279-281.
10. 　Squier CA.The stretching of mouse skin in vivo: effect on epidermal proliferation and thickness[J].J Invest Dermato, 1980, 74(2): 68-71.
11. 　Cozart RF, Atchison JR, Lett ED, et al. The use of controlled subatmospheric pressure to promote wound healing in preparation for split-thickness skin grafting in a fourth degree burn[J]. Tenn Med, 1999, 92(10): 382-384.
12. 　Nakazawa T, Yasuhara H, Shigematsu K, et al. Smooth muscle cell migration induced by shear-loaded platelets and endothelial cells.Enhanced PDGF Production by shear-loaded platelets[J]. Int angiol, 2000, 19(2): 142-146.
13. 　Saxena V, Hwang CW, Huang S, et al.Vacuum-assisted closure: micro deformations of wounds and cell proliferation[J].Plast Reconstr Surg, 2004, 114(5): 1086-1096.
14. 　Kilpadi D, Bower CE, Reade CC. Effect of vacuum-assisted closure therapy on early systemic cytokine levels in a swine model[J]. Wound Rep Reg, 2006, 14(2): 210-215.
15. 　江苏阳, 陈绍宗, 胡绍华, 等. 封闭式负压引流技术对大鼠创面愈合过程中VEGF和Bcl的影响[J]. 中国美容医学, 2003, 12(2): 142-146.
16. 　Moran SG, Windham ST, Cross JM, et al. Vacuum-assisted complex wound closure with elastic vessel loop augmentation. A novel technique[J]. J Wound Care, 2003, 12(6): 212-213.
17. 　Younan G, Ogawa R, Ramirez M, et al. A nalysis of nerve and neuropeptide patterns in vacuum-assisted closure-treated diabetic murine wound[J]. Plast Reconstr Surg, 2010, 126(1): 87-96.
18. 　Saaiq M, Hameed-Ud-Din, Khan MI, et al. Vacuum-assisted closure therapy as a pretreatment for split thickness skin graft[J]. J Coll Physicians Surg Pak, 2010, 20(10): 675-679.
19. 　周业平, 田鹏, 于东宁, 等. 41例胸骨骨髓炎的外科综合治疗[J]. 中华损伤与修复杂志, 2010, 5(3): 16-18.
20. 　Scholl L, Chang E, Reitz B, et al. Sternal osteomyelitis: use of vacuum-assisted closure device as an adjunct to definitive closure with sternectomy and muscle flap reconstruction[J]. Arch Orthop Trauma Surg, 2004, 19(5): 453-461.
21. 　Nakayama M. Applying negative pressure therapy to deep pressure ulcers covered by soft necrotic tissue[J]. Int Wound J, 2010, 7(3): 160-166.
22. 　黄雄飞, 杜靖远. 封闭式负压引流治疗开放性骨折合并软组织缺损[J]. 中华创伤杂志, 1998, 14(3): 183.
23. 　马丹, 刘敏, 马兵, 等. VSD在5·12地震伤员下肢挤压伤后骨筋膜间隙综合征中的应用[J]. 重庆医学, 2009, 38(2): 150-151.
24. 　Whitehead SJ, Forest-Bendien VL, Richard JL, et al. Economic evaluation of vacuum assisted closure therapy for the treatment of diabetic foot ulcers in France[J]. Int Wound J, 2010, 8(1): 22-32.
25. 　Stansby G, Wealleans V, Wilson L, et al. Clinical experience of a new NPWT system in diabetic foot ulcers and post-amputation wounds[J]. J Wound Care, 2010, 19(11): 496, 498-502.
26. 　Nather A, Chionh SB, Han AY, et al. Effectiveness of vacuum-assisted closure (VAC) therapy in the healing of chronic diabetic foot ulcers[J]. Ann Acad Med Singapore, 2010, 39(5): 353-358.
27. 　Rispoli DM, Horne BR, Kryzak TJ, et al. Description of a technique for vacuum-assisted deep drains in the management of cavitary defects and deep infections in devastating military and civilian trauma[J]. J Trauma, 2010, 68(5): 1247-1252.
28. 　李荣刚, 刘兴炎. MRI与病理学评价封闭式负压引流技术早期治疗肢体枪弹伤疗效[J].中国修复重建外科杂志, 2010, 24(3): 335-339.
29. 　陈炯, 周建军, 苏国亮, 等. 早期负压封闭引流治疗深II度烧伤创面的临床疗效评价[J].中华烧伤杂志, 2010, 26(3): 170-174.
30. 　Topaz M, Bisker O, Litmanovitch M, et al. Application of regulated oxygen-enriched negative pressure-assited wound therapy in combating anaerobic infections[J]. Eur J Plast Surg, DOI 10.1007/s00238-010-0514-5.
31. 　Citak M, Backhaus M, Meindl R, et al. Rear complication after VAC-therapy in the treatment of deep sore ulcers in a paraplegic patient[J]. Arch Orthop Trauma Surg, 2010, 130(12): 1511-1514.
32. 　Hourigan LA, Linfoot JA, Chung KK, et al. Loss of protein, immunoglobulins, and electrolytes in exudates from negative pressure wound therapy[J]. Nutr Clin Pract, 2010, 25(5): 510-516.
33. 　Ho CH, Powell HL, Collins JF, et al. Poor nutrition is a relative contraindication to negative pressure wound therapy for pressure ulcers: preliminary observations in patients with spinal cord injury[J]. Adv Skin Wound Care, 2010, 23(11): 508-516.
34. 　李婧, 陈绍宗. 封闭负压引流技术对创面微循环流速和血管口径影响的实验研究[J]. 现代康复, 2000, 4(12): 1848-1849.
35. 　Borgquist O, Ingemansson R, Malmsjö M, et al. Wound edge microvascular blood flow during negative-pressure wound therapy: examining the effects of pressure from-10 to-175 mm Hg[J]. Plast Reconstr Surg, 2010, 125(2): 502-509.
36. 　Malmsjö M, Lindstedt S, Inqemansson R, et al. Influence on pressure transduction when using different drainage techniques and wound fillers (foam and gauze) for negative pressure wound therapy[J]. Int Wound J, 2010, 7(5): 406-412.
37. 　Hurd T, Chadwick P, Cote J, et al. Impact of gauze-based NPWT on the patient and nursing experience in the treatment of challenging wounds[J]. Int Wound J, 2010, 7(6): 448-455.
38. 　Scimeca CL, Bharara M, Fisher TK, et al. Novel use of insulin in continuous-instillation negative pressure wound therapy as “wound chemotherapy” [J]. J Diabetes Sci Technol, 2010, 4(4): 820-824.
39. 　Scimeca CL, Bharara M, Fisher TK, et al. Novel use of doxycycline in continuous-instillation negative pressure wound therapy as “wound chemotherapy” [J]. Foot Ankle Spec, 2010, 3(4): 190-193.
40. 　Franczyk M, Lohman RF, Aqarwal JP, et al. The impact of topical lidocaine on pain level assessment during and after vacuum-assisted closure dressing changes: a double-blind, prospective, randomized study[J]. Plast Reconstr Surg, 2009, 124(3): 854-861.

West China Medical Journal

负压引流技术在临床应用中的研究进展

Abstract Full text Figures/Tables Video References Cited by

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