Change and Significance of Urinary Total Bile Acids in Intrahepatic Cholestasis with Pregnancy_West China Medical Journal

Authors：

XU Zhou ² , XING Aiyun ¹ , WAN Hongfang ¹ , et al. ¹

1.Department of Gynecology and Obstetrics，West China Second Hospital，Sichuan University，Chengdu 610041;2.Department of Gynecology and Obstetrics，the Second Affiliated Hospital，Chongqing University of Medical Sciences，Chengdu 610031，China;

Corresponding author：

XING Aiyun, Email:

Keywords：

总胆汁酸; 妊娠期肝内胆汁淤积症; 尿液

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目的：测定妊娠期肝内胆汁淤积症(ICP)患者血清及尿液的胆汁酸水平，探讨ICP时母体胆汁酸转运的变化及意义。方法：ICP患者(ICP组)及正常妊娠(对照组)各20例。血清及尿液总胆汁酸测定采用速率法。结果：(1)ICP组与对照组相比，血清及尿液中总胆汁酸水平均明显升高，差异有显著性(P lt;0.05)；(2)对照组尿液总胆汁酸水平明显高于血清，差异有显著性(P lt;0.05)，而ICP组血清和尿液总胆汁酸水平无显著性差异(P gt;0.05)；(3)两组中血清与尿液总胆汁酸水平均无相关性(P gt;0.05)。结论：ICP患者母血中总胆汁酸水平明显增加，而总胆汁酸经尿液的排泄未成比例增加，这可加重胆汁淤积，引起围产儿不良结局。

Citation： XU Zhou,XING Aiyun,WAN Hongfang,et al.. Change and Significance of Urinary Total Bile Acids in Intrahepatic Cholestasis with Pregnancy. West China Medical Journal, 2009, 24(2): 317-319. doi: Copy

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13.	Soroka CJ，Cai SY，Boyer JL.Effects of cholestasis on the regulation of membrane transporter expression in intestine and kidney(Abstract)[J].Hepatology，2002，36：462A..
14.	Oelkers P，Kirby LC，Heubi JE，et al.Primary bile acid malabsorption caused by mutations in the ileal sodiumdependentbile acid transporter gene(SLC10A2)[J].J Clin Invest，1997，99：1880-1887..

1. Glantz A，Marschall HU，Mattsson LA.Intrahepatic cholestasis of pregnancy：Relationships between bile acid levels and fetal complication rates[J].Hepatology，2004，40：467-474..
2. Reyes H.The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy[J].Gastroenterol Clin North Am，1992，21：905-921..
3. Raedsch R，Lauterburg BH，Hofmann AF.Altered bile acid metabolism in primary biliary cirrhosis[J].Dig Dis Sci，1981，26：394-401.
4. Colombo C，Roda A，Roda E，et al.Correlation between fetal and meternal serum bile acid concentrations[J].Pediatr Res，1985，19：227-231..
5. Mazzella G，Nicola R，Francesco A，et al.Ursodexycholic acid administration in patients with cholestasis of pregnancy：effects on primary bile acids in babies and mothers[J].Hepatology，2001，33：504-8.
6. Williamson C，Gorelik J，Eaton BM，et al.The bile acid taurocholate impairs rat cardiomyocyte function：a proposed mechanism for intrauterine fetal death in obstetric cholestasis[J].Clin sci，2001；100：363-369..
7. Aguilar Spivey JR.In vitro studies of bile salt toxicity[J].Hepatology，1994，19：1538-1541..
8. 夏松云，陈竹钦，李力.妊娠期肝内胆汁淤积症患者胎盘血管内皮生长因子的变化及其意义[J].中国医师杂志，2003，8：1068-70..
9. Thomassen PA.Urinary bile acids during development of recurrent cholestasis of pregnancy[J].Eur J Clin Invest，1979，9(6)：417-23..
10. Carddock AL，Love MW，Daniel RW，et al.Expression and transport properties of the human ileal and renal sodiumdependent bile acid transporter[J].Am J Physiol Gastrointest Liver Physiol，1998，278：G157-G169..
11. Kullakublick GA，Hagenbuch B，Stieger B，et al.Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver[J].Gastroenterology，1995，109：1274-1282..
12. Schaub TP，Kartenbeck J，Konig J，et al.Expression of the MRP2 geneencoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma[J].J Am Soc Nephrol，1999，10：1159-1169..
13. Soroka CJ，Cai SY，Boyer JL.Effects of cholestasis on the regulation of membrane transporter expression in intestine and kidney(Abstract)[J].Hepatology，2002，36：462A..
14. Oelkers P，Kirby LC，Heubi JE，et al.Primary bile acid malabsorption caused by mutations in the ileal sodiumdependentbile acid transporter gene(SLC10A2)[J].J Clin Invest，1997，99：1880-1887..

West China Medical Journal

Change and Significance of Urinary Total Bile Acids in Intrahepatic Cholestasis with Pregnancy

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