目的:观察七氟醚靶控用于低流量吸入麻醉维持的临床规律及血流动力学变化,寻求靶控下的药物量化指标。方法:选择60例20～60岁手术患者,随机分2组每组30例:P组(丙泊酚)常规实施全凭静脉TCI靶控麻醉;S组(七氟醚),实施低流量七氟醚靶控吸入麻醉(BIS值40)。分别记录诱导前(T1),插管后5(T2)、15(T3)、30(T4)45(T5)、60(T6)、90(T7)、120(T8)min时的、MBP、HR、;Sev组患者加记各个时点的七氟醚IT、ET的MAC值。结果:T2点两组均比T1 降低(P lt;0.05),S 组高于P组(P lt;0.05),两组比较T3至T7无显著性差异(P gt;0.05);S 组T3 至T7 各点ET值无统计学差异,ET%:2.46,约1.4 MAC。结论:(1)七氟醚诱导较静脉麻醉诱导患者血流动力学稳定,(2)低流量七氟醚靶控吸入麻醉维持平稳,调控简便,效果良好。
Citation：
SU Tao,WANG Zaiyi,WU Xiangyi,et al. A Clinical Comparison Between Low Flow Sevoflurane TargetControlled and TCI of Propofol. West China Medical Journal, 2009, 24(7): 1695-1698. doi:
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Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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- 1. 庄心良,曾因明,陈伯銮.现代麻醉学[M].3版.北京:人民卫生出版社,2003:446-448.
- 2. VIITANEN H, ANNILA P, VIITANEN M, et al. Premeditation with midazolam delays recovery after ambulatory sevoflurane anesthesia in children[J].Anesth Analg,1999,8(91):75.
- 3. MALAN TPJ, DINARDO J A, ISNER R J, et al. Cardiovascular effects of servo fluraneeom Pared with those of isofiurane in volunteers[J]. Anesthesiology,1995,83:918-28.
- 4. MAPLESON W W. Effec to fageon MAC analysis[J].Br J Anaesth,1996,76:179-85.
- 5. EGER EL ZND, SAIDNLAN L J, BRANDSTATER B. Minimum alveolar anesthetic concentration:a standard of anesthetic potency[J].Anesthesiology,1965,26:756-63.
- 6. KEIJZER C, PEREZ R S, DE LANGE J J. Compound A and carbon monoxide production from sevoflurane and seven different types of carbon dioxide absorbent in a patient model[J]. Acta Anaesthesiol Scand, 2007, 51:31-37.
