目的:探讨平阳霉素/博来霉素联合顺铂(BP方案)、5氟尿嘧啶+异环磷酰胺联合顺铂(FIP方案)在宫颈癌新辅助化疗(Neoadjuvant Chemotherapy, NACT)的疗效及临床意义。方法:2004～2008年我院收治的Ib2-IIb期巨块型宫颈癌共62例,其中36例行BP或FIP方案化疗1～2个疗程后行根治性手术,为研究组;另26例直接行根治性手术,为对照组;术前评价NACT的疗效,并比较两组术中出血量、术后病理特征及并发症。结果:研究组36例患者术前进行NACT有效率为86％;术后病理检查示淋巴结阳性率,阴道切缘阳性率及宫旁累及率均较对照组低,差异有显著性。结论:利用BP,FIP方案对宫颈癌患者进行新辅助化疗有效、安全、经济,可缩小癌肿体积,增加手术切除率。
Citation：
WANG Tongjie,XIONG Dongmei. Clinical Effects of Neoadjuvant Chemotherapy on 36 Cases with Cervical Carcinoma. West China Medical Journal, 2009, 24(7): 1703-1704. doi:
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- 4. EDLTORZA GILLIAN M,THOMAS.Neoadjuvant chemotherapy a useful strategy for the treatment off stage Ib cervix cancer[J].Gynecol Oncology,1993,49(2):153-155.
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