目的:探讨盐敏感性高血压患者胰岛素抵抗与脂联素代谢异常的关系。方法:对100例高血压患者采用急性盐水负荷试验,确定65例为盐敏感性(SS)高血压患者,35例为盐不敏感性(NSS)高血压患者,选定正常人50例为对照组,分别测其胰岛素水平、血脂、血尿酸及脂联素水平。结果:高血压患者存尿酸、胆固醇、甘油三酯水平升高(P lt;0.01),SS组较NSS组的血尿酸、血胆固醇、血甘油三脂增高(P lt;0.01)。SS组脂联素［(6.04±2.08)ng/mL］,较NSS组［(7.89±3.35)ng/mL(P lt;0.01)］降低,且SS组存在胰岛素抵抗,HOMA指数分别为［2.54±0.53,2.21±0.55(P lt;0.01)］。血浆脂联素水平与胰岛素抵抗指标存在正相关,r=-0.36,(P lt;0.01)。结论:盐敏感性高血压患者存在胰岛素抵抗及脂联素降低,胰岛素抵抗可能是其他代谢异常及脂联素降低的基础。
Citation：
WANG Mian,CHEN Xiaoping. Relationship Between Insulin Resistance and Adiponectin in Salt Sensitive Hypertensive Patients. West China Medical Journal, 2009, 24(7): 1714-1716. doi:
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- 2. BILHORAC A, TEZCAN H, OZENER, et al. Association between salt sensitivity and target organ damage in essential hypertension[J]. Am J Hypertens, 2000, 13:846-872.
- 3. JOHN S W, KREGE J H, OLIVER P M, et al. Genetic decreases in atrial natriuretic peptide and saltsensitive hypertension[J]. Science, 1995, 267:679-681.
- 4. GALISTEO M, GARCIASAURA M F, JIMENEZ R, et al. Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetatesalthypertensive rats[J]. Mol Cell Biochem, 2004, 259:91-99.
- 5. ZHOU M S, JAIMES E A, RAIJ L. Atorvastatin prevents endorgan injury in saltsensitive hypertension:role of eNOS and oxidant stress[J]. Hypertension, 2004, 44:186-90.
- 6. 刘文辉, 刘治全, 等. 慢性盐负荷对血压正常盐敏感性个体胰岛素抗性的影响[J ]. 高血压杂志, 1998, 6 (2):1111.
- 7. OHASHIK, KIHARA S, OUCHIN, et al. Adiponection replenishmenl amelionatca obeaityrelated hypentension [J]. Hypentension. 2006,47(6):1108-1116.
- 8. ADAMCZAK M, WIECEK A, FUNAHASHI T, et al.〖WTBZ〗Decreased plasmal.adiponectin concent ration in patients with essential hypertension[J]. Am J hypertens,2003,16(1),72-75.
