目的 探讨胰腺囊腺瘤和囊腺癌的临床病理特点及其诊治。
方法 回顾性分析山东省菏泽市立医院及曹县人民医院1996年6月至2007年3月共收治的17例患者的临床病理资料。
结果 本病临床表现无特征性。B超和CT检查能发现囊肿但不能确定类型。浆液性囊腺瘤7例均行肿瘤局部切除; 黏液性囊腺瘤6例,行胰十二指肠切除1例,胰体尾切除5例; 囊腺癌4例,行胰十二指肠切除加淋巴结清扫1例,胰体尾切除术2例,胰体尾加脾切除1例。光镜下浆液性囊腺瘤囊壁由扁平或立方上皮细胞组成; 黏液性囊腺瘤囊壁由高柱状上皮细胞组成,可见乳头状突起; 囊腺癌囊壁细胞核异形明显,可见核分裂象及间质浸润。15例获得B超随访,中位随访时间为42个月(1~129个月),除1例行胰体尾切除加脾切除的老年囊腺癌患者术后6个月死于营养衰竭和 1例胰十二指肠切除患者并发糖尿病外,其余患者生存满意,未见肿瘤复发。
结论 B超和CT是本病的主要影像检查方法。加强对本病临床病理特征的认识是提高诊治率的关键。手术切除治疗本病疗效满意。
Citation:
魏志新,赵博,沙元革,赵瑞平. Clinicopathologic Features,Diagnosis and Treatment of Pancreatic Cystadenoma and Cystadenocarcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(4): 467-468. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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Femandez-del Castillo C, Targarona J, Thayer SP, et al. Incidental pancreas cysts: clinicopathologic characteristics and comparison with symptomatic patiients [J]. Arch Surg, 2003; 138(4)∶427.
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王单松, 靳大勇, 楼文晖, 等. 胰腺囊腺瘤和囊腺癌的诊断及外科治疗 [J]. 中华普通外科杂志, 2007; 22(1)∶55.
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Sarr MG, Carpenter HA, Prabhakar LP, et al. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms? [J]. Ann Surg, 2000; 231(2)∶205.
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Bassi C, Salvia R, Molinari E, et al. Management of 100 consecutive cases of pancreatic serous cystadenoma: wait for symptoms and see at imaging or vice versa? [J]. World J Surg, 2003; 27(3)∶319.
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- 1. Femandez-del Castillo C, Targarona J, Thayer SP, et al. Incidental pancreas cysts: clinicopathologic characteristics and comparison with symptomatic patiients [J]. Arch Surg, 2003; 138(4)∶427.
- 2. 王单松, 靳大勇, 楼文晖, 等. 胰腺囊腺瘤和囊腺癌的诊断及外科治疗 [J]. 中华普通外科杂志, 2007; 22(1)∶55.
- 3. 沈魁, 钟守先, 张圣道主编. 胰腺外科 [M]. 第1版. 北京: 人民卫生出版社, 2000∶383~388.
- 4. 吴泓, 熊先泽, 程南生, 等. 胰腺囊腺癌的诊断(附36例报告) [J]. 中国普外基础与临床杂志, 2005; 12(5)∶509.
- 5. Warshaw AL, Compton CC, Lewandrowski K, et al. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients [J]. Ann Surg, 1990; 212(4)∶432.
- 6. 魏志新, 宝荣, 孙智勇, 等. 胰腺实性假乳头状瘤的病理特点及诊治体会 [J]. 中华普通外科杂志, 2007; 22(2)∶96.
- 7. Brugge WR, Lauwers GY, Sahani D, et al. Cystic neoplasms of the pancreas [J]. N Engl J Med, 2004; 351(12)∶1218.
- 8. Jimenez RE, Warshaw AL, Z’graggen K, et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy [J]. Ann Surg, 1999; 230(4)∶501.
- 9. Sarr MG, Carpenter HA, Prabhakar LP, et al. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms? [J]. Ann Surg, 2000; 231(2)∶205.
- 10. Bassi C, Salvia R, Molinari E, et al. Management of 100 consecutive cases of pancreatic serous cystadenoma: wait for symptoms and see at imaging or vice versa? [J]. World J Surg, 2003; 27(3)∶319.