Objective To study the effects of long term application of cathartics on electromyography of rat colon, and to explore the role of interstitial cells of Cajal (ICC) in it.
Methods Colonic slow waves of the rat was examined after 3-month feeding of phenolphthalein, and ICC in myenteric plexus was observed by ZIO method, and ultrastructure changes of nerves and ICC was observed. Results The frequency of slow waves of cathartic colon was reduced significantly(Ｐ＜0.05). The distribution of ICC in myenteric plexus was uneven, and the processes were mussily connected each other. Vacuolar degeneration of axon and ICC-like cells was revealed by electron microscope in myenteric plexus of cathartic colon.
Conclusion Long term application of phenolphthalein could reduce the frequency of colonic slow waves, and the possible mechanism was degeneration of ICC and myenteric plexus nerves.
Citation：
TONG Weidong,ZHANG Shengben,ZHANG Lianyang,et al.. ROLE OF INTERSTITIAL CELLS OF CAJAL IN ELECTROMYOGRAPHY OF CATHARTIC COLON OF RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(5): 288-290. doi:
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- 1. Smith B. Effect of irritant purgatives on the muenteric plexus in man and mouse 〔Ｊ〕. Gut, 1968; 9(1)∶139.
- 2. 童卫东， 蔡文琴， 张胜本. Cajal间质细胞研究进展 〔Ｊ〕. 解剖科学进展， 1997； 3(1)∶214.
- 3. Christensen J, Rick GA, Lowe LS. Distribution of interstitial cells of Cajal in stomach and colon of cat, dog, ferrit, opossum, rat, guinea pig and rabbit 〔Ｊ〕. J Auto Nerv Syst, 1992; 37(1)∶45.
- 4. 童卫东， 张胜本， 张连阳等. 大黄致大鼠结肠壁内一氧化氮异常及意义 〔Ｊ〕. 中药药理与临床， 1997； 13(6)∶29.
- 5. Smith B. Pathologic changes in the colon produced by anthraquinone purgatives 〔Ｊ〕. Dis Colon Rectum, 1973; 16(3)∶455.
- 6. Fioramonti J, Dupuy C, Bueno L. In vivo motility of rat colon chronically pretreated with sennosides 〔Ｊ〕. Pharmacology, 1993; 47(Suppl 1)∶155.
- 7. Huizinga JD, Thuneberg L, Vanderwinden JM, et al. Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders 〔Ｊ〕. Trends Pharmacol Sci, 1997; 18(10)∶393.
- 8. Hulzlnga JD, Thuneberg L, Kluppel M, et al. W/kit gene required for intestinal cells of Cajal and for intestinal pacemaker activity 〔Ｊ〕. Nature, 1995; 373(26)∶347.
- 9. Zhou DS, Komuro T. Ultrastructure of the zinc iodideosmic acid stained cells in guinea pig small intestine 〔Ｊ〕. J Anat, 1995； 187(3)∶481.
