THE EXPRESSION AND SIGNIFICANCE OF TRANSFORMING GROWTH FACTOR-β1 IN THE HEALING PROCESS OF BILE DUCT_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Hepatobiliary Surgery, The First Hospital, Xi’an jiaotong University of Medical Sciences, Xi’an 710061;

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Keywords：

Bile duct Wound healing Immunohistochemistry Transforming growth factor-β1

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Objective To observe the expression and distribution of transforming growth factor-β1 (TGF-β1) in the healing process of bile duct and discuss its function and significance in the process of benign biliary stricture formation. Methods An injury to bile duct of dog was made and then repaired. The expression and distribution of TGF-β1 in the tissue at different time of the healing process were studied after operation with immunohistochemical SP staining.
Results TGF-β1 staining was observed in the granulation tissue, fibroblasts and endothelial cells of blood vessels. High expression of TGF-β1 was observed in the healing process lasting for a long time.
Conclusion The high expression of TGF-β1 is related closely with the fibroblast proliferating activity, extracellular matrix overdeposition and scar proliferation in the healing process of bile duct.

Citation： GENG Zhimin,XIANG Guoan,HAN Qing,et al.. THE EXPRESSION AND SIGNIFICANCE OF TRANSFORMING GROWTH FACTOR-β1 IN THE HEALING PROCESS OF BILE DUCT. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(6): 362-363. doi: Copy

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1. 傅小兵，王德文主编. 创伤修复基础〔M〕. 第1版. 北京: 人民军医出版社, 1997∶127～166.
2. 王文革, 钱云良, 商庆新. 细胞因子与瘢痕形成机制的研究进展〔J〕. 中华整形烧伤外科杂志, 1997； 13(2)∶128.
3. Desmouliere A, Geinoz A, Gabbiani F, et al. Transforming growth factorβ1 induces αsmooth musle actin expression in granulation tissue myofibroblasts 〔J〕.J Cell Biol, 1993； 122(2)∶103.
4. Abergel RR, Dizzurro D, Muker CA. Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloids fibroblast cultures 〔J〕. J Invest Dermatol, 1985; 84(4)∶384.
5. Dicesare PE, Chang DT, Perlman N, et al. Alternation of collagen composition and crosslinking in keloids tissues 〔J〕. Matrix, 1990; 10(2)∶172.
6. Zhang K, Carner W, Cohen L, et al. Increased types Ⅰ and Ⅲ collagen and transforming growth factorβ1 mRNA and protein in hypertrophic burn scar 〔J〕. J Invest Dermatol, 1995； 104(6)∶750.
7. Mast BA, Krummel TM. Acute inflammation in fetal wound healing 〔M〕. In: NS Adzick, MT Longaker, eds. Fetal wound healing. New York: Elsevier Science, 1992∶227-240.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE EXPRESSION AND SIGNIFICANCE OF TRANSFORMING GROWTH FACTOR-β1 IN THE HEALING PROCESS OF BILE DUCT

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