ADVANCES IN GENETIC DIAGNOSIS OF PANCREATIC CANCER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIANG Jinbo , XU.. Feng

Department of General Surgery, The First Affiliated Hospital, Shandong University of Medical Sciences, Jinan 250012;

Corresponding author：

Keywords：

Pancreatic cancer Genetic diagnosis

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Abstract Full text Figures/Tables Video References Cited by

Objective To search for the significant gene indicators in the diagnosis of pancreatic cancer.
Methods Literatures about genetic diagnosis of pancreatic cancer were collected and reviewed.
Results K-ras, p53, DPC4 and telomerase genes were considered to play important roles in the diagnosis of pancreatic cancer.
Conclusion Detection of the genes related to pancreatic cancer may be of helpful in early diagnosis of pancreatic cancer.

Citation： JIANG Jinbo,XU.. Feng,SHOU Nanhai.. ADVANCES IN GENETIC DIAGNOSIS OF PANCREATIC CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(6): 408-410. doi: Copy

1.	Parker SL, Tong T, Bolden S, et al. Cancer statistics 〔Ｊ〕. CA Cancer J Clin, 1997; 47(1)∶5.
2.	Tada M, Ohashi M, Shiratori T, et al. Analysis of Kras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease 〔Ｊ〕. Gastroenterology, 1996; 110(1)∶227.
3.	Tateishi K, Tada M, Yamagata M, et al. High proportion of mutant Kras gene in pancreatic juice of patients with pancreatic cystic lesion 〔Ｊ〕. Gut, 1999; 45(5)∶737.
4.	Caldas C, Hahn SA, Hruban RH, et al. Detection of Kras mutation in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia 〔Ｊ〕. Cancer Res, 1994; 54(13)∶3568.
5.	Hugh EM, Jacquekine L, Christine L, et al. A prospective study of Kras mutation in the plasma of pancreatic cancer patient 〔Ｊ〕. Clin Cancer Res, 1998; 4(2)∶272.
6.	Yamada T, Nakamori S, Ohzato H, et al. Detection of Kras gene mutation in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathology feature 〔Ｊ〕. Clinic Cancer Res, 1998; 4(6)∶1527.
7.	Demeure MJ, Doffek KM, Komorowski PA, et al. Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reactionbased assay 〔Ｊ〕. Cancer, 1998; 83(7)∶1328.
8.	Demeure MJ, Doffek KM, Komorowski RA, et al. Molecular metastases in stage Ⅰ pancreatic cancer: improved survival with adjuvant chemoradiation 〔Ｊ〕. Surgery, 1998; 124(4)∶663.
9.	Inoue S, Nakao A, Kasai Y, et al. Dectection of hepatic micrometastasis in pancreatic adenocarcinoma patients by twostage polymerase chain reaction/restriction fragment length polymorphism analysis 〔Ｊ〕. Jpn J Cancer Res, 1995; 86(7)∶626.
10.	Suwa H, Ohshio G, Okada N, et al. Clinical significance of serum p53 antigen in patients with pancreatic carcinoma 〔Ｊ〕. Gut, 1997; 40(5)∶647.
11.	Lundin J, Nordling S, von Boguslawsky K, et al. Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer 〔Ｊ〕. Oncology, 1996; 53(2)∶104.
12.	Makinen K, Hakala T, Lipponen P, et al. Clinical contribution of bcl2, p53 and ki67 protein in pancreatic ductal adenocarcinoma 〔Ｊ〕. Anticancer Res, 1998; 18(1B)∶615.
13.	Wright WE, Shay JW, Piatyszek MA, et al. Modification of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity 〔Ｊ〕. Nucleic Acid Res, 1995; 23(18)∶3794.
14.	Hiyama E, Kodama T, Shinbara K, et al. Telomerase activity is detected in pancreatic cancer but not in benign tumors 〔Ｊ〕. Cancer Res, 1997; 57(2)∶326.
15.	Iwao T, Hiyama E, Yokoyama T, et al. Telomerase activity for the preoperative diagnosis of pancreatic cancer 〔Ｊ〕. J Natl Cancer Inst, 1997; 89(21)∶1621.
16.	O’Beien C. New tumor suppressor found in pancreatic cancer 〔Ｊ〕. Science, 1996; 271(5247)∶294.
17.	Grau AM, Zhang L, Wang W, et al. Induction of p21 wafl expression and growth inhibition by transforming growth factor bate involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells 〔Ｊ〕. Cancer Res, 1997; 57(18)∶3927.
18.	Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 〔Ｊ〕. Science, 1996; 271(5247)∶350.
19.	Rozenblum E, Schutte M, Goggins M, et al. Tumorsuppressive pathways in pancreatic carcinoma 〔Ｊ〕. Cancer Res, 1997; 57(9)∶1731.
20.	Apple SK, Hecht M, Lewin DN, et al. Immunohistochemical evaluation of Kras, p53 and HER2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis 〔Ｊ〕. Hum Pathol, 1999; 30(2)∶23.

1. Parker SL, Tong T, Bolden S, et al. Cancer statistics 〔Ｊ〕. CA Cancer J Clin, 1997; 47(1)∶5.
2. Tada M, Ohashi M, Shiratori T, et al. Analysis of Kras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease 〔Ｊ〕. Gastroenterology, 1996; 110(1)∶227.
3. Tateishi K, Tada M, Yamagata M, et al. High proportion of mutant Kras gene in pancreatic juice of patients with pancreatic cystic lesion 〔Ｊ〕. Gut, 1999; 45(5)∶737.
4. Caldas C, Hahn SA, Hruban RH, et al. Detection of Kras mutation in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia 〔Ｊ〕. Cancer Res, 1994; 54(13)∶3568.
5. Hugh EM, Jacquekine L, Christine L, et al. A prospective study of Kras mutation in the plasma of pancreatic cancer patient 〔Ｊ〕. Clin Cancer Res, 1998; 4(2)∶272.
6. Yamada T, Nakamori S, Ohzato H, et al. Detection of Kras gene mutation in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathology feature 〔Ｊ〕. Clinic Cancer Res, 1998; 4(6)∶1527.
7. Demeure MJ, Doffek KM, Komorowski PA, et al. Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reactionbased assay 〔Ｊ〕. Cancer, 1998; 83(7)∶1328.
8. Demeure MJ, Doffek KM, Komorowski RA, et al. Molecular metastases in stage Ⅰ pancreatic cancer: improved survival with adjuvant chemoradiation 〔Ｊ〕. Surgery, 1998; 124(4)∶663.
9. Inoue S, Nakao A, Kasai Y, et al. Dectection of hepatic micrometastasis in pancreatic adenocarcinoma patients by twostage polymerase chain reaction/restriction fragment length polymorphism analysis 〔Ｊ〕. Jpn J Cancer Res, 1995; 86(7)∶626.
10. Suwa H, Ohshio G, Okada N, et al. Clinical significance of serum p53 antigen in patients with pancreatic carcinoma 〔Ｊ〕. Gut, 1997; 40(5)∶647.
11. Lundin J, Nordling S, von Boguslawsky K, et al. Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer 〔Ｊ〕. Oncology, 1996; 53(2)∶104.
12. Makinen K, Hakala T, Lipponen P, et al. Clinical contribution of bcl2, p53 and ki67 protein in pancreatic ductal adenocarcinoma 〔Ｊ〕. Anticancer Res, 1998; 18(1B)∶615.
13. Wright WE, Shay JW, Piatyszek MA, et al. Modification of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity 〔Ｊ〕. Nucleic Acid Res, 1995; 23(18)∶3794.
14. Hiyama E, Kodama T, Shinbara K, et al. Telomerase activity is detected in pancreatic cancer but not in benign tumors 〔Ｊ〕. Cancer Res, 1997; 57(2)∶326.
15. Iwao T, Hiyama E, Yokoyama T, et al. Telomerase activity for the preoperative diagnosis of pancreatic cancer 〔Ｊ〕. J Natl Cancer Inst, 1997; 89(21)∶1621.
16. O’Beien C. New tumor suppressor found in pancreatic cancer 〔Ｊ〕. Science, 1996; 271(5247)∶294.
17. Grau AM, Zhang L, Wang W, et al. Induction of p21 wafl expression and growth inhibition by transforming growth factor bate involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells 〔Ｊ〕. Cancer Res, 1997; 57(18)∶3927.
18. Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 〔Ｊ〕. Science, 1996; 271(5247)∶350.
19. Rozenblum E, Schutte M, Goggins M, et al. Tumorsuppressive pathways in pancreatic carcinoma 〔Ｊ〕. Cancer Res, 1997; 57(9)∶1731.
20. Apple SK, Hecht M, Lewin DN, et al. Immunohistochemical evaluation of Kras, p53 and HER2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis 〔Ｊ〕. Hum Pathol, 1999; 30(2)∶23.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

ADVANCES IN GENETIC DIAGNOSIS OF PANCREATIC CANCER

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