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find Keyword "化学治疗" 44 results
  • Current Status and Prospect of Surgical Treatment for Colorectal Cancer

    Release date:2016-09-08 11:47 Export PDF Favorites Scan
  • Research progress on drug therapy for metastatic colorectal cancer

    Objective To understand the latest research progress of chemotherapy, targeted therapy and immunotherapy drugs in the treatment of metastatic colorectal cancer. Method The literature on the efficacy of different treatment drugs for metastatic colorectal cancer in recent years both domestically and internationally was retrieved and reviewed. Results There had been many clinical research progress in the treatment of metastatic colorectal cancer, new drugs had emerged, targeted drugs were particularly prominent, and more trials of therapeutic drugs and drug combination treatment regimens were also being carried out. Different treatment methods were applied to patients according to the mutation status of RAS/RAF and the expression of mismatch repair protein, the survival benefit varied greatly. Conclusion Precision medicine is becoming increasingly important, screening patients to choose appropriate treatment modality can further improve survival benefit.

    Release date:2023-08-22 08:48 Export PDF Favorites Scan
  • Concomitant chemoradiation followed by radical surgery for locally advanced cervical cancer patients: a randomized controlled trial

    ObjectivesTo explore the efficacy of simultaneous chemoradiotherapy combined with surgery for locally advanced cervical patients and perform multivariable analysis.MethodsA total of 130 cases of patients with locally advanced cervical cancer who were admitted to the Second Affiliated Hospital of Fujian Medical University from June 2012 to December 2016 were randomly divided into case group and control group. The patients in the control group were treated with platinum-based radical concurrent chemoradiation. In the case group, patients received both treatment in the control group with the addition of extensive hysterectomy and pelvic lymph node dissection. The short-term efficacy and survival outcomes of the two groups were compared.ResultsThe present study was the final report of this randomized controlled trial. 68 patients were randomly enrolled into the case group and 50 patients into control group. The non-microscopic residual tumor (non-MRT) rates were 83.8% (57/68) and microscopic residual tumor (MRT) rates were 2.9% (2/68) in the experimental group. There was no significant difference between two groups (χ2=0.008, P=0.928) in 3-year progression-free survival rate (65.6%vs. 59.6%) and 4-year progression-free survival rate (52.5% vs. 56.3%). And there was no significant difference between two groups (χ2=0.361, P=0.548) in 3-year overall survival rate (80.3%vs. 74.6%) and 4-year overall survival rate (77.6% vs. 64.9%). Multivariable analysis showed that only tumor size and parametrial invasion were significant prognostic factors of PFS (P<0.05). And only parametrial invasion was a potential prognostic indicator affecting OS (P=0.078).ConclusionParametrial invasion is an important prognostic factor. Radical concurrent chemoradiotherapy combined with surgical treatment of locally advanced cervical cancer has not significantly improved progression-free survival and overall survival. The treatment regimen should be applied with caution and selectivity.

    Release date:2019-01-15 09:51 Export PDF Favorites Scan
  • 皮肤NK/T细胞淋巴瘤的治疗与研究现状

    结外鼻型NK/T细胞淋巴瘤(ENKTCL)是一种少见疾病,其分布具有明显的地域和种族特征,西方国家比较少见,多发生于亚洲、墨西哥及中南美洲,占所有非霍奇金淋巴瘤的5%~18%。按解剖部位被划分为上呼吸消化道NK/T细胞淋巴瘤(UAT-NKTCL)和非上呼吸消化道NK/T细胞淋巴瘤(NUAT-NKTCL)。在非上呼吸消化道病例中,皮肤往往是瘤体最常侵犯的器官。皮肤受累的结外鼻型NK/T细胞淋巴瘤称为皮肤NK/T细胞淋巴瘤(CNKTCL),包括了原发于皮肤以及原发于皮肤外的晚期ENKTCL皮肤浸润,但是不论是疾病原发或是继发的晚期皮肤浸润,其病程进展快,预后差,中位生存时间<12个月。侵袭性淋巴瘤常用的化学疗法方案如CHOP(环磷酰胺+多柔比星+长春新碱+泼尼松)或者CHOP类似方案以及对鼻部早期患者证实有效的局部放射治疗在皮肤NK/T患者中并未带来明显的生存获益,目前新的治疗方案还在探索中。随着肿瘤分子生物学的标靶干预和基因组研究的深入进展,靶向治疗有望为CNKTCL患者带来福音。本文将着重就CNKTCL治疗现状和预后加以综述。

    Release date:2016-09-08 09:11 Export PDF Favorites Scan
  • Fluoropyrimidine-induced cardiotoxicity: a review of diagnosis and management

    Fluoropyrimidines have been the standard care as ajuvant or palliative treatment for malignant gastrointestinal carcinoma over several decades. Their common adverse effects include gastrointestinal effects, myelosuppression, and hand-foot syndrome. Besides, fluoropyrimidines are the second cause of chemotherapy-induced cardiotoxicity and have the different manifestation and machanisms from anthracyclines. With the development of onco-cardiology, increasing concern is raised on fluoropyrimidine-induced cardiotoxicity. This review addresses the epidemiology, clinical manifestation, and proposed mechanisms; and also highlights the diagnosis, monitoring and management of fluoropyrimidine-induced cardiotoxicity.

    Release date:2018-04-23 05:00 Export PDF Favorites Scan
  • 肺切除术联合化疗治疗耐多药肺结核51例

    摘要: 目的 探讨肺切除联合化疗治疗耐多药肺结核的临床应用价值,总结治疗经验。 方法 1999年1月至2007年1月,我科共收治51例主病灶局限于肺叶或单侧全肺的耐多药肺结核患者,男38例,女13例;年龄18~56岁,平均年龄36.5岁。施行肺叶切除术30例,肺叶加同侧肺段切除术或同侧双肺叶切除术11例,全肺切除术10例;分析术后继续抗结核化疗18~24个月的疗效。 结果 51例患者均手术成功,46例完成化疗(18~24个月)后治愈;治疗失败5例,其中3例在疗程最后6个月痰菌仍为阳性,2例于围手术期内死于术后并发症。术后发生并发症12例,其中术后1个月内发生9例:呼吸功能衰竭3例,均经呼吸机辅助呼吸治愈;脓胸3例,2例经胸腔闭式引流治愈,1例术后3周死于多器官功能衰竭;支气管胸膜瘘1例,经留置胸腔引流管3个月后瘘口逐渐闭合治愈;暂时性视力障碍1例,未作特殊处理,1个月后视力恢复正常,急性肺水肿1例,治疗无效死亡。1个月后发生并发症3例:切口感染2例,经开放引流每日换药,行二期缝合伤口Ⅲ/丙愈合;支气管胸膜瘘1例,行胸部肌瓣填塞+胸廓成形术后支气管胸膜瘘再度复发,给予胸壁开放式引流,长期未愈,72个月后因大咯血窒息死亡。 结论 对主病灶局限的耐多药肺结核患者施行肺切除联合抗结核化疗,治愈率高,并发症发生率及病死率均在可接受范围内。

    Release date:2016-08-30 06:02 Export PDF Favorites Scan
  • Change of BAG 3 Expression of Pancreatic cancer Tissues and Cell Lines after Chemotherapy

    【Abstract】Objective To analyze the function of BAG3 in antiapoptosis and chemotherapy resistance induction process of pancreatic cancer.Methods The expressions of BAG-3 in pancreatic cancerous tissues of patients with chemotherapy and those without chemotherapy before resection were determined by immunohistochemistry. The expression difference of BAG-3 protein 18 hours after cultured with chemotherapy drugs (concentration of drugs: 5-FU 50 μg/ml, MMC 0.5 μg/ml, EADM 1.5 μg/ml) of 3 pancreatic cancer cell lines (MIACaPa-2, PANC-1, SW1990) was measured through Western blotting method.Results The median positive rate of pancreatic cancer tissue from patients accepted chemotherapy before resection was higher than those not accepted chemotherapy, but there wasn’t significant difference. Eighteen hours after cultured with drugs, the level of BAG-3 of this three cell lines had significant increased compared with control group (P<0.05). Conclusion Chemotherapy induces elevation of BAG-3 expression of pancreatic cancer. The upregulate of BAG-3 may associate with the chemotherapy resistance induced by drugs.

    Release date:2016-08-28 04:28 Export PDF Favorites Scan
  • Treatment of Bleeding and Prolapse of Hemorrhoids by Copper Ion Electrochemistry

    Objective To evaluate treatment of the bleeding and prolapse of hemorrhoids by copper ion electrochemistry.Methods All patients suffered from the bleeding and prolapse of internal hemorrhoids or mixed hemorrhoids were included in this study. There were 202 patients in trial group (79 patients with internal hemorrhoids,123 patients with mixed hemorrhoids). Control group contained 171 cases (64 patients with internal hemorrhoids,107 patients with mixed hemorrhoids). There were 56 patients with prolapse of inner hemorrhoids or mixed hemorrhoids. Copper ion electrochemistry was performed in trial group. Suppository was used in control group. After the rectum was sterilized, the copper needle was inserted into the hemorrhoid with the depth about 8-15 mm. Then we continued the therapy for 4 minutes and 40 seconds. Other hemorrhoids were treated in the same way. Results The cure rate in trial group with hemorrhoidal bleeding was 98.0%,special virtual rate was 1.50%,virtual rate was 0.5%, inefficiency rate was 0 (U=44.6,Plt;0.001). The cure rate in control group was 11.1%,special virtual rate was 24.6%,virtual rate was 28.1%,inefficiency rate was 36.3%. The cure rate of prolapse group was 48.2%,special virtual rate was 33.9%,virtual rate was 17.9%. The patients didn’t feel uncomfortable and recovered 4 hours later after operation. Conclusion This therapy was safe, effective and simple.

    Release date:2016-08-28 04:47 Export PDF Favorites Scan
  • Concomitant chemoradiation followed by radical surgery for locally advanced cervical cancer patients: preliminary results from a randomized, controlled trial

    Objective To evaluate the radical chemoradiotherapy plus surgery for locally advanced cervical patients. Methods 102 cases of patients with locally advanced cervical cancer were randomly divided into a trial group and a control group. In the control group, patients received radical chemoradiotherapy only, with chemotherapy consisted of cisplatin 35-40 mg/m2, one times a week. In the trial group, patients received both treatment in the control group and extensive hysterectomy and pelvic lymph node dissection. Results Fifty-two patients were randomly enrolled into the trial group and 50 patients into the control group. The microscopic residual tumor (MRT) rate was 5.8% (3/52) and non-microscopic residual tumor (NMRT) rate was 82.7% (43/52) in the trial group. Progression-free survival time was 3-40 months with a median survival time of 23 months, and the 3-year progression-free survival rate was 73.1% in the trial group, and progression-free survival time was 5–41 months with a median survival time of 22 months, and the 3-year progression-free survival rate was 64.8% in the control group; while the difference was not statistically significant (χ2=0.092,P=0.761). Overall survival time was 6–40 months with median overall survival time of 23 months, and the 3-year overall survival rate was 82.7% in the trial group, and overall survival time was 5-41 months with a median survival time of 22.5 months, and the 3-year overall survival rate was 81.8%; while the difference was not statistically significant (χ2=0.338,P=0.561). Conclusion Concomitant chemoradiation followed by radical surgery could not significantly improve progression-free survival and overall survival in patients with locally advanced cervical cancer. The treatment regimen should be applied with caution and selectivity.

    Release date:2017-01-18 07:50 Export PDF Favorites Scan
  • Refractory recurrent metastatic parathyroid carcinoma: MDT of a case and literatures review

    ObjectiveTo summarize the experience of comprehensive treatment of parathyroid carcinoma (PTC).MethodThe clinicopathologic data of patient with PTC admitted to the First Affiliated Hospital of Kunming Medical University were retrospectively analyzed.ResultsThe patient was a 42-year-old male, who was diagnosed with the primary hyperparathyroidism after suffering from systemic joint pain for more than 2 years. The patient accepted the first operation in a primary hospital, including the resection of the PTC and ipsilateral thyroid lobectomy, and the PTC was confirmed pathologically. The second operation was performed due to the tumor relapse within thyroid bed. The third operation was performed with the palliative resection of the recurrent tumor in the right neck and the three-dimensional conformal radiation therapy was performed. The fourth operation was performed in the left neck with lateral lymph node dissection of level Ⅲ and level Ⅳ. The lower left lung cuneiform resection was performed in the fifth operation. For the last operation, the mediastinal metastatic tumor was removed with thoracoscopy. The multiple imaging evaluation showed no evidence of recurrence in the neck, but the extensive pulmonary metastasis occurred.ConclusionsSurgery is the only effective treatment for PTC. En bloc excision consists of resection of primary tumor, ipsilateral thyroid lobectomy, other surrounding structures involved by the tumor and central neck dissection. During operation, tumor rupture should be avoided. Accessible metastatic tumor should be resected when possible. Radiotherapy should be performed in patient with local infiltration or unresectable tumor. Effect of chemotherapy for PTC is poor. Supportive medical care should be given for fatal hypercalcemia in patient when treatment failed to control tumor.

    Release date:2019-11-25 02:42 Export PDF Favorites Scan
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