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视网膜母细胞瘤侵犯视神经和脉络膜的临床病理分析

我们对87例经病理诊断为视网膜母细胞瘤(RB)并有视神经或脉络膜侵犯的病理切片作详细复查,分析其就诊年龄、病程、临床分期及组织学分型与视神经、脉络膜受累的关系。发现视神经、脉络膜受侵犯的程度随病程的延长而增加，肿瘤的搞基、转移与肿瘤细胞分化的程度亦有一定关系。提出临床应与病理紧密联系，根据病理检查结果作出相应的治疗选择，以减少RB转移的危险因素。同时，还乙随访的23例病人进行简要分析。 （中华眼底病杂志，1994，10：243-245）

必须重视感染性眼内炎的危害和诊治

Clinical histopathological and misdiagnostic analysis of 359 cases of intraocular tumors

Objective To probe the clinical character,the histopathological classification and misdiagnoses of intraocular tumors. Methods The clinical and pathological data of 359 patients with intraocular tumor diagnosed clinically between 1980～2000 were retrospectively analyzed. Results There were 300 cases of malignant tumor and 23 cases of benign tumor respectively. Non-oncologic malady and benign tumor misdiagnosed as tumor or malignant tumor were 40 cases. The two leading malignant tumors were retinoblastoma and melanoma. Conclusion The clinical and pathological analysis of intraocular tumor is beneficial to the correct clinical diagnosis and treatment. (Chin J Ocul Fundus Dis,2002,18:28-30)

先天性黄斑缺损伴聋哑一例

葡萄膜与结膜色素性肿瘤DNA含量的定量研究

PURPOSE: To evaluate the value of cellular DNA content and proliferative activity in an attempt to distinguish between benign and malignant or to estimate malignant potential of conjunetival and uveal pigmental tumors. METHODS :Cellular DNA content ,proliferative index(PI) and s-phase fraction(SPF)from uveal malignant melanomas (UMM),conjunctival nevi (CN) and malignant melanomas (CMM) were measured by flow cytometry(FCM). RESULTS:Seven cases of CN were diploid,aneuploid incidence of 7 cases of CMM and 39 cases of UMM was 57.14% and 74.36% respectively. SPF and PI in CMM were significantly higher than SPF (Plt;0.05) and PI(Plt;0.01)in CN;DNA index (DI) and aneuploid incidence in UMM were related to different pathological category (Plt;0.01). In 19 cases of UMM,there was a significantly positive correlation between DI and argyrophilic nucleolar organizer regions (AgNORs) asssociated proteins areas (Plt;0.01). CONCLUSIONS: It is suggested that aneuploid might be a characteristic feature of CMM and UMM ;SPF and PI might be used as adjunctive indexes in distinguishing between benign and malignant conjunctival melanomas :DI and silver-stained areas replenish each other to provide tumor biological information in different aspects. （Chin J Ocul Fundus Dis,1996,12: 94- 97）

脉络膜平滑肌瘤一例

本文报告1例男性，52岁，因右眼视力下降5月，检查见眼底下方视网膜灰白色包块隆起，经B超及CT扫描，发现右眼球内占位病变；临床拟诊为脉络膜恶性黑色素瘤，经病理确诊为脉络膜平滑肌瘤。 （中华眼底病杂志，1992，8：175-176）

The clinico-pathological analysis of choroidal metastatic carcinom aarising from lung carcinoma

Objective To observe the clinical and pathological characteristics of choroidal metastatic carcinoma from lung carcinoma.Methods The clinical and pathological data of 6 patients with choroidal metastatic carcinoma from lung carcinima were analysed retrospectively.Results All the 6 patients had severe visual impairment, including 3 with severe ophthalmalgia. Flat neoplasm were seen in the posterior pole of the eyes in all the 6 patients and retinal detachment were found in 5 patients. Fundus fluorescein angiography (FFA) examination had been performed on 1 patient and blocked fluorescence and hyperfluorescence were seen in the lesion with pinpoint fluorescein leakage loop around it. CT examination had been performed on 3 patients and the shadow of flat homogenous tumor was seen. MRI examination had been performed on 1 patient and high signal intensit ies on T1W and low signal intensities on T2W were found. In all the 6 patients with primary lung carcinoma, 5 were diagnosed with adenocarcinoma and 1 with cellule carcinoma through pathological examination, and 5 patients were diagnosed with choroidal metastatic carcinoma from adenocarcinoma and 1 with choroidal metastatic carcinoma from cellule carcinoma through pathological examination.Conclusion Rapid visual acuity decrease, severe ophthalmalgia, flat neoplasm in ocular fundus and secondary retinal detachment are the main clinical characteristics of the choroidal metastatic carcinoma from lung carcinoma. Most histopathologica l manifestations of the metastatic carcinoma like that of the primary focus, and adenocarninoma is the most common histoclassification. (Chin J Ocul Fundus Dis，2003，19：333-404)

视网膜神经细胞瘤一例

视网膜脱离术后伴酵母样菌感染一例

von Hippel-Lindau病伴双眼眼内骨化一例

报告1例von Hippel-Lindau病伴双眼眼内骨化的病例。该女性患者除有多灶性的视网膜血管瘤及严重的晚期并发症外，其中枢神经系统的毛细血管母细胞瘤发生于额叶实属罕见。既往病史及CT检查有助于眼内骨化的诊断。 （中华眼底病杂志，1994，10：40-41）