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find Author "张明" 69 results
  • Yamane 式后房型人工晶状体植入术后眼内炎一例

    Release date:2021-09-24 01:23 Export PDF Favorites Scan
  • 中心性浆液性脉络膜视网膜病变的光动力治疗

    中心性浆液性脉络膜视网膜病变(CSC),是一种好发于中青年男性的自限性疾病,但由于易反复发作,且对中心视力的严重损害往往是不可逆的,所以寻求安全有效的治疗方法一直是研究的热点。近几年来,光动力疗法(PDT)在不同发展阶段的CSC应用备受关注。现对PDT治疗CSC的进展作一综述。

    Release date:2016-09-07 02:38 Export PDF Favorites Scan
  • 渗出型老年性黄斑变性治疗药物的研究进展

    抗血管内皮生长因子(VEGF)生物制剂ranibizumab(商品名Lucentis)、pegaptanib(商品名Macugen)等的临床应用,改变了渗出型老年性黄斑变性(AMD)等脉络膜新生血管(CNV)疾病药物治疗的格局,但需要长时间反复玻璃体腔注射是其主要缺点。一些新型的VEGF受体融合蛋白、络氨酸激酶抑制剂、RNA干扰分子、调节细胞生长和代谢的sirolimus、整合素(integrin)拮抗剂以及基因治疗均引起了研究者关注,而且有些已经显露出良好的应用前景。随着对眼部新生血管机制研究的进一步深入,有望开发一些针对新生血管整个信号传递多个环节的治疗药物,或通过基因治疗手段在AMD病灶区域长久表达抗血管生成药物,为AMD的药物治疗带来了新的希望。

    Release date:2016-09-02 05:40 Export PDF Favorites Scan
  • 癫痫患者心率变异性的研究进展

    越来越多的研究发现癫痫患者存在发作相关的及发作间期的心脏自主神经功能障碍,并提示可能为癫痫猝死的机制之一。同时有学者从自主神经功能着手探索预测、减少或者控制癫痫发作的方法并取得了一定的成果。心率变异性(Heart rate variability,HRV)作为近年来被广泛认可的评估心脏自主神经功能的非侵入性检查方法,在癫痫领域的研究应用日益广泛。但是癫痫患者心脏自主神经功能障碍的影响因素及具体机制尚无定论。文章就癫痫HRV的相关研究作一综述。

    Release date:2017-07-26 04:06 Export PDF Favorites Scan
  • Development trend and new understanding of contemporary vitrectomy

    Vitrectomy is an important treatment for vitreoretinal diseases. After half a century of innovation and development, it has made a breakthrough from open type to micro-incision surgery. Minimally invasive vitrectomy has the advantages of wide indications and high cutting efficiency, which greatly improves the safety and efficacy of surgery, and minimizes the occurrence of trauma and complications during surgery. At present, with the development of surgical microscope system, ophthalmic microsurgery robot and other equipment, and the development and application of new artificial vitreous materials, vitrectomy is developing toward minimally invasive, accurate and intelligent development. The further development of vitrectomy innovative technology in the field of ophthalmology is hopeful in the future, so that clinicians can achieve the best surgical results with the minimum damage, and bring better light to patients.

    Release date:2022-11-16 03:11 Export PDF Favorites Scan
  • Evolution of optical coherence tomography

    Optical coherence tomography (OCT) is a non-invasive, rapid optical medical imaging modality and has become a hot topic in biomedical research. In recent years, several functional OCTs have emerged, including Doppler OCT, polarization-sensitive OCT, spectroscopic OCT, and optical coherence tomographic elastography, etc. These newer advances in functional OCT broaden the potential clinical application of OCT by providing novel ways to observe and understand tissue activity that cannot be accomplished by other current imaging methodologies.

    Release date:2018-11-22 04:28 Export PDF Favorites Scan
  • Understanding the development status of ophthalmic artificial intelligence, holding the challenges and opportunities

    With the rapid development of artificial intelligence (AI), especially deep learning, AI research in the field of ophthalmology has presented a trend of diversification in disease types, generalization in scenarios and deepening in researches. The AI algorithm has showed a good performance in the studies of diabetic retinopathy, age-related macular degeneration, glaucoma and other ocular diseases, yielding up the great potential of ophthalmic AI. However, most studies are still in their infancy, and the application of ophthalmic AI still faces many challenges such as lack of interpretability for results, deficiency of data standardization, and insufficiency of clinical applicability. At the same time, it should also be noted that the development of multi-modal imaging, the innovation of digital technologies (such as 5G and the Internet of Things) and telemedicine, and the new discovery that retina status can reflect systemic diseases have brought new opportunities for the development of ophthalmic AI. Learn the current status of AI research in the field of ophthalmology, grasp the new challenges and opportunities in its development process, successfully realizing the transformation of ophthalmic AI from research to practical application.

    Release date:2021-03-19 07:10 Export PDF Favorites Scan
  • Current status of low vision in a population with opportunistic diabetes based on a physical examination center

    ObjectiveTo investigate the current status of visual disability in people with opportunistic diabetes based on the physical examination center, and explore its related factors. MethodsPeople who went to West China Hospital of Sichuan University (West China Hospital district and Wenjiang hospital district) for physical examination between January 2019 and March 2020 were selected. The subjects were those who had a history of diabetes or fasting blood glucose≥7 mmol/L or glycosylated hemoglobin≥6.5%. They were divided into two groups according to visual acuity. The physical examinees with low vision were the observation group, and the physical examinees with normal vision were the control group (the number of cases was twice that of the observation group). The relevant data of the two groups were observed and compared, and the risk factors of low vision were analyzed by logistic regression. ResultsA total of 1 636 physical examinees with diabetes were included. There were 158 cases in the observation group and 316 cases in the control group. 158 cases (203 eyes) had low vision, and the incidence was 6.20% (203/3272). The main diseases leading to low vision were cataract (92 cases, 58.23%), high myopia (32 cases, 20.25%) and diabetes retinopathy (20 cases, 12.66%). Logistic regression analysis showed that the independent risk factors for low vision were age of diabetes patients, diabetes retinopathy, systolic blood pressure and glycosylated hemoglobin. ConclusionsThe incidence of low vision in diabetes population based on physical examination centers in Chengdu is low. Visual acuity examination should be strengthened for diabetes patients, especially the elderly, with diabetes retinopathy, high systolic blood pressure and glycosylated hemoglobin. Early effective prevention and treatment can reduce the damage to vision caused by diabetes.

    Release date:2022-06-27 09:55 Export PDF Favorites Scan
  • 心因性非癫痫性发作影像学检查方法的应用进展

    心因性非癫痫性发作(Psychogenic non-epileptic seizures,PNES)是阵发性疾病,临床症状与癫痫十分相似,临床上 PNES 确诊的金标准是视频脑电图(VEEG)。近年来,随着影像学技术的发展,一些影像学检查方法也已用于 PNES 的辅助诊断。回顾近年的相关文献,对 PNES 的影像学检查方法的应用进展进行综述。

    Release date:2018-03-20 04:09 Export PDF Favorites Scan
  • 频域光相干断层扫描的C-扫描图像解读

    频域光相干断层扫描(SD-OCT)的C-扫描功能实现了对视网膜各个层面进行独立的曲面拟合,用此功能对临床常见的玻璃体视网膜界面疾病、视网膜及脉络膜疾病进行检查、分析和评估时,能够更好地对特定层面进行分析。认识C-扫描图像的特征,探讨其形成的组织学基础,有助于加深对视网膜疾病发生发展过程的认识,对于视网膜病变诊断、随访、治疗及预后的评估都具有重要的指导意义。

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
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