west china medical publishers
Keyword
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Keyword "恶性肿瘤" 158 results
  • Treatment Experience of Unable Excision for Malignant Obstructive Jaundice in 68 Cases

    目的 探讨不能手术治疗的恶性梗阻性黄疸给予介入治疗及术后行放射治疗的效果。方法 对笔者所在单位2006年6月至2011年6月期间收治的68例不能手术治疗的恶性梗阻性黄疸患者在X线导向下行经皮经肝胆道内外引流及金属内支架引流术,对胆道金属内支架置入术后行放射治疗的临床资料进行回顾性分析与总结。结果 行内外引流管引流28例次,金属内支架置入63例次。55例胆管癌患者胆道金属内支架置入后再行放射治疗,13例患者单纯行胆道内外引流管引流,全部患者的黄疸均得到改善。行胆管肿瘤组织活检51例和胆汁脱落细胞学检查68例,总阳性率为58.8% (40/68),术后0.5、1及3年存活率分别为95.6% (65/68),70.6% (48/68)和14.7% (10/68)。结论 恶性梗阻性黄疸在失去手术治疗机会后采用介入治疗解除胆管梗阻,减轻肝脏损害,胆道金属内支架置入术后再行放射治疗,有助于提高患者生存质量,延长患者生存时间。

    Release date:2016-09-08 10:37 Export PDF Favorites Scan
  • Characteristics of Alu Repeats and Their Relationships with Malignant Tumors

    【Abstract】ObjectiveTo discuss the molecular structures and functions of Alu repeats,and its relationships with malignant tumors. MethodsAdvances in molecular biology and oncology of Alu repeats in recent years had been reviewed. ResultsHomologous recombination between Alu repeats may result in various genetic exchanges,including duplications, deletions and translocations,cause a series of malignancy alteration by activating some oncogenes. ConclusionAlu repeats as a sort of multifunction regulatory sequences may play an important role during the carcinogenesis and progression of some tumors.

    Release date:2016-09-08 11:54 Export PDF Favorites Scan
  • THE SIGNIFICANCE OF TUMOR SUPRESSOR GENES INACTIVATION IN CARCINOGENESIS OF MULTIPLE PRIMARY NEOPLASM

    Objective To investigate the effect of tumor suppressor gene on tumourigenesis in multiple primary malignant neoplasm (MPMN).Methods The retrospective analysis was used to summarize several common tumor suppressor genes correlation to MPMN. Results At current study of the tumor suppressor genes, the common genes studied in MPMN were p53, APC, p16, BRCA1, BRCA2 and PTEN/MMAC1, etc. The same mutation of tumor suppressor genes could be detected from PMNNs. Conclusion There are significant relations between MPMN and inactivation of tumor suppressor gene. By the study of tumor suppressor gene, it can reveal some common rules of tumourigenesis of MPMN.

    Release date:2016-09-08 02:01 Export PDF Favorites Scan
  • Shen-Mai Injection as an Adjunct Therapy to Tumor Chemotherapy: A Systematic Review

    Objective To assess the methodological quality of clinical studies using Shen-Mai injection as an adjunct therapy to tumor chemotherapy and to evaluate its efficacy and safety. Methods A comprehensive search strategy was designed to identify all randomized controlled trials (RCT) comparing Shen-Mai injection plus routine chemotherapy versus routine chemotherapy alone by searching for the CBMdisc (issue 3) and TCMLRS database (1981-2001). The methodological quality of the trials was assessed by two reviewers independently for which a meta analysis was perfermed. Results Thirteen RCTs met the inclusion criteria. methodological quality was poor (all the trials included were level C). Compared with the control group, the combined outcome of Shen-Mai injection increased the effect of chemotherapy (OR 1.73 95%CI 1.27 to 2.34, P=0.000 4), reduced the side effect of bone marrow inhibition (OR 0.29, 95%CI 0.16 to 0.52, P=0.000 04) in WBC counting and (OR 0.11, 95%CI 0.02 to 0.49, P=0.004 in PLT count. And Shen-Mai injection relieved the symptoms of nausea and vomiting (OR 0.26, 95%CI 0.16 to 0.43, Plt;0.000 01). Conclusions The methodological quality of the trails using Shen-Mai injection should be improved. Based on the results of the review and the meta-analysis, Shen-Mai injection may have positive effects on chemotherapy in patients with malignant tumor, although the evidence is weak. No serious adverse events are reported. Further well-designed clinical trials should be performed.

    Release date:2016-08-25 03:34 Export PDF Favorites Scan
  • 肝移植现状与面临的挑战

    进入21世纪以来,肝移植已经成为治疗终末期肝脏疾病、急性暴发性肝功能衰竭的一种最有效的选择。据美国UNOS报道,在过去10年中,全世界已实施26 040例肝移植; 在先进的移植中心,肝移植受者的1年和3年存活率分别达到90%和80%,5年存活率达65%~75%,儿童肝移植和亲属活体肝移植存活率更高,除了存活时间延长外,生活质量得到明显改善,包括恢复工作和生育能力。国内近年来肝移植也得到快速发展,年移植数在千例左右,开展的单位不断增加,存活率得到提高,在先进的单位,开展的项目和水平逐渐接近国际水平。

    Release date:2016-08-28 04:49 Export PDF Favorites Scan
  • Advancements in investigating Gas6/Axl in gastrointestinal malignant tumors

    Objective To understand the research progress and future prospects of the growth arrest specific protein 6/Axl receptor tyrosine kinase (Gas6/Axl) signaling pathway in gastrointestinal malignant tumors. Method Retrieve relevant literature on the Gas6/Axl signaling pathway in gastrointestinal malignant tumors and analyze and summarize. Results The Gas6/Axl signaling pathway was abnormally upregulated and activated in gastrointestinal malignancies, leading to malignant cell proliferation, invasion, and metastasis, thereby promoting the occurrence and development of gastrointestinal malignancies. At present, in the field of gastrointestinal cancer, the research of Gas6/Axl signaling pathway mainly involved tumor angiogenesis, tumor drug resistance, mesenchymal epithelial transformation, and tumor microenvironment. Conclusions The Gas6/Axl signaling pathway plays a critical role in governing various cellular processes and downstream effects. Its aberrant expression contributes to the development and advancement of gastrointestinal malignancies through diverse mechanisms. Thoroughly exploring the involvement of the Gas6/Axl signaling pathway in gastrointestinal tumors is of utmost significance, as it holds the potential to unveil novel therapeutic targets for effective management of gastrointestinal malignancies.

    Release date:2023-08-22 08:48 Export PDF Favorites Scan
  • Fifty-Eight Cases of Operations for Biliary Malignant Tumor by Using da Vinci Surgical System

    ObjectiveTo summarize the clinical experience of 58 operations for biliary malignant tumor with da Vinci surgical system. MethodsFrom January 2009 to October 2010, 180 patients with hepatopancreaticobiliary and gastrointestinal disease underwent robotic surgeries by using da Vinci surgical system, including 58 patients with biliary malignant tumor. The case distribution, intra and postoperative data were analyzed. ResultsOf 58 patients, 3 patients with intrahepatic bile duct cystadenocarcinoma received wedge resections of liver. In 36 patients with hilar cholangiocarcinoma, anatomical left hemihepatectomies were performed in 3 cases, resection of extrahepatic duct and gallbladder bridge type biliary revascularization in 3 cases, resection of extrahepatic duct and biliary-enteric Roux-en-Y anastomosis in 14 cases, tumor resection and revascularization of hepatic portal bile duct in 1 case, palliative external drainage of intrahepatic bile duct in 5 cases, and Y-internal drainage of hepatic portal in 10 cases. In 10 patients with gallbladder carcinoma, resection of extrahepatic duct and gallbladder and biliaryenteric Roux-en-Y anastomosis in 2 cases, cholecystectmy in 3 cases, cholecystectmy and external drainage of intrahepatic bile duct in 1 case, cholecystectmy and Y-internal drainage by suspension of hepatic portal in 4 cases. A patient with middle bile duct cancer received radical resection of cholangiocarcinoma and biliary-enteric Roux-en-Y anastomosis. Of 8 patients with distal bile duct cancer, Whipple procedure were performed. Of 58 patients, 2 cases converted to hand-assistant procedure (3.4%). For all patients, operation time was (6.18±1.71) h, blood loss was (116.66±56.06) ml, blood transfusion was (85.55±38.28) ml, ambulation time was (9.10±2.91) h, feeding time was (14.95±4.35) h, and hospital stay was (12.81±4.29) d. Postoperative complications occurred in 8 cases (13.8%), including bile leakage (3 cases), wound bleeding (1 case), pancreatoenteric anastomotic leakage (2 cases), pulmonary infection (1 case), and renal failure (1 case). Of these 8 cases, 6 cases recovered smoothly and 2 cases die of severe pulmonary infection and renal failure after conservative treatment (3 or 4 weeks), therefore, the mortality of patients was 3.4%. In 36 patients with hilar cholangiocarcinoma, 19 cases died (on 2 monthes 4 cases, on 6 monthes 5 cases, on 10 monthes 8 cases, and on 12 monthes 2 cases after operation), 11 cases survival well (gt;26 monthes 4 cases, gt;22 monthes 3 cases, and gt;19 monthes 4 cases), and 6 cases required hospitalization. Of 10 patients with gallbladder carcinoma, 7 cases died (on 3 monthes 1 case, on 5 monthes 1 case, on 8 monthes 1 case, on 11 monthes 3 cases, and on 12 monthes 1 case after operation) and 3 cases survival (gt;17 monthes 2 cases, gt;13 monthes 1 case). In 8 cases undergoing pancreatoduodenectomy, 5 cases died (on 4 monthes 2 cases, on 6 monthes 2 cases, and 10 monthes 1 case after operation) and 3 cases survived well over 2 years. Three patients with intrahepatic bile duct cystadenocarcinoma survived over 1 year. Conclusionsda Vinci surgical system can carry out all kinds of surgery for biliary malignant tumor, especially prominent in the complicated surgeries for hepatic portal, which breaks through the restricted area of laparoscope in hepatobiliary malignant tumor.

    Release date:2016-09-08 10:41 Export PDF Favorites Scan
  • Efficacy of High-dose Three-dimensional Conformal Radiotherapy Combined with Surgery on Primary Retroperitoneal Soft Tissue Sarcoma

    【摘要】 目的 评价大分割适形放射治疗对腹膜后软组织肿瘤术后患者的治疗作用。 方法 对1998年10月-2003年4月收治的16例腹膜后软组织急性肿瘤术后患者行大分割适形放射治疗,设计临床靶区等效生物剂量为55~62 Gy,观察放疗后2、5年局部控制率、生存率和无病生存情况。 结果 2、5年局部控制率较未行放疗患者明显提高并和其他放射治疗方式达到较高治疗剂量者近似;远期生存无改善,无病生存率较未行放疗患者有提高。 结论 大分割适形放射治疗方式对腹膜后软组织急性肿瘤术后患者有较好的局部控制作用,无瘤生存率有提高,远期生存无改善,无严重的远期放疗后遗症。【Abstract】 Objective To observe the effect of high-dose three-dimensional conformal radiotherapy combined with surgery on primary retroperitoneal soft tissue sarcoma. Methods A total of 16 patients with primary retroperitoneal soft tissue sarcoma underwent high-dose three-dimensional conformal radiotherapy after sarcoma excision from October 1998 to April 2003. The biologically effective dose was 55-62 Gy for CTV. The local control rate and long-term survival rate and disease free survival after 2 and 5 years were observed. Results The local control rate obviously raised in these patients after 2 and 5 years; but the long-term survival rate didn’t improve and the disease free survival improved in these patients compared with those wasn’t radiated. Conclusion High-dose three-dinensional comfomal radiotherapy is effective on the patients with retroperitoneal soft tissue sarcoma in local control rate and disease free survival, but long-term survival rate is not improved and the side-effect is not serious.

    Release date:2016-08-26 02:21 Export PDF Favorites Scan
  • 树突状细胞联合细胞因子诱导杀伤细胞治疗晚期恶性肿瘤患者近期临床疗效观察

    目的观察研究树突状细胞(DC)联合细胞因子诱导杀伤细胞(CIK)协同治疗晚期恶性肿瘤患者的近期临床疗效。 方法采集2013年1月-6月104例晚期恶性肿瘤患者外周血单个核细胞进行DC、CIK细胞培养,7~14 d后回输患者体内,观察治疗期不良反应症状及治疗前后免疫指标、生活质量变化情况,并评估治疗后病情缓解情况。 结果治疗期低热5例,乏力3例,皮疹1例,无其他任何不良反应症状;治疗后患者外周血中CD3+、CD4+及自然杀伤细胞百分比上升,CD8+细胞百分比下降,生活质量指标及Karnofsky功能状态评分均有改善,差异有统计学意义(P<0.05);68例可测量病灶患者治疗后部分缓解18例,稳定42例,进展8例,客观缓解率为26.5%,疾病稳定率为88.2%。 结论DC/CIK细胞免疫治疗在杀灭肿瘤细胞的同时,可以修复患者免疫系统,改善患者生活质量,且安全性高,不良反应小,可成为继手术、放射治疗、化学治疗后晚期恶性肿瘤治疗的重要手段。

    Release date: Export PDF Favorites Scan
  • 代谢组学在肺恶性肿瘤中的应用

    代谢组学( metabonomics/metabolomies) 是近年来发展很快的一门新学科, 与基因组学、蛋白质组学、转录组学一起构成了生物系统学, 在后基因时代的研究已成为热点。代谢组学处于基因组和蛋白质组的下游, 是基因组和蛋白质组的补充, 能够更为灵敏地鉴定出基因改变、疾病和环境因素作用所产生的特定代谢型( metabotype) 。随着各大检测分析技术的发展和联用, 使得代谢组学在生命科学诸多领域均有广泛应用, 尤其在肿瘤学方面。代谢组学以小分子代谢物为研究对象, 运用高通量、高敏感度的分析技术, 结合化学计量方法, 从代谢角度描述肿瘤病理过程的瞬间概况, 揭示恶性肿瘤整体性代谢变化, 在肿瘤早期诊断、预后判断以及个体化治疗等方面的研究具有独特优势和临床应用价值。

    Release date:2016-09-13 03:54 Export PDF Favorites Scan
16 pages Previous 1 2 3 ... 16 Next

Format

Content