Total hip arthroplasty (THA) is the mainstay of treatment for advanced hip arthritis, but a number of postoperative wound complications may occur, such as wound dehiscence, bleeding and infection. Among them, wound infection is one of the serious complications after THA, which may lead to hip dysfunction or even disability, prolong hospital stay, increase readmission rate and significantly increase related medical expenses. Therefore, further understanding and action to change modifiable risk factors associated with wound infection will not only reduce medical expenses, but also improve the prevention, treatment and care. This article reviews the risk factors of surgical wound infection over the past 5 years, including patients factors (serum albumin, serum transferrin, blood transfusion, congestive heart failure, diabetes, overweight or obesity, smoking, and long-term use of hormone) and medical factors (previous surgery, surgical approach, length of surgery, and operating room environment).
In order to investigate the therapeutic effects of ultrashort wave and He-Ne laser on experimentally infected skin flaps, 24 lower abdominal skin flaps on 24 rabbits were established, under each flap 1 ml of S. aureus (9 x 10(8) bacterials/ml) was injected respectively. Then, ultrashort wave and He-Ne laser were utilized respectively in 2 groups once a day for 6 days, with on treatment in two another two groups as control groups. After the period of treatment, the 4 groups were evaluated in the bacterial amounts, thickness of skin flaps and degree of infection. The results showed that the skin flaps in the treatment groups were much better than those in the control groups. It suggested that both the ultrashort wave and He-Ne laser are helpful in the treatment of infection of S. aureus in skin flaps.
目的 分析外科手术部位感染率过低的原因，掌握手术部位感染诊断标准，减少医院感染漏报，及时发现医院感染流行趋势，采取控制措施，防止医院感染暴发。 方法 选择开展较多、手术部位一旦发生感染对患者安全威胁性较大的手术：包括胆囊切除或（和）胆管手术，结肠、直肠切除术，阑尾切除术，疝手术，乳房切除术，剖宫产，子宫切除术及附件切除术，全髋关节置换术，食道贲门手术，腰椎间盘摘除术，监测时间为2011年1月1日－6月30日及2012年1月1日－6月30日，共监测1 180例手术，对手术部位感染率进行对比分析。 结果 2011年半年监测手术部位感染率1.99%，调整感染率4.74%；比国内报道低6～9倍；通过分析原因，对医院感染诊断标准再培训、加强病原微生物送检等，2012年半年监测手术部位感染率4.68%，调整感染率32.12%；与2011年比较差异有统计学意义（χ2=141.841，P=0.000）。 结论 手术部位感染率偏低的原因是医生漏报所致；采取整改措施后，提高了手术部位感染的识别能力，减少了漏报，对及时发现医院感染暴发具有重要意义。
Infectious and infection-related optic neuritis is an important type of optic neuritis. Infectious optic neuritis is caused by direct spread of pathogenic organism to optic nerve from local infection or blood transmission. Infection-related optic neuritis is caused by pathogens-induced immune allergic reaction. They present with atypical clinical features of optic neuritis, including progressive vision loss, persistent eye pain or headache, ineffectiveness or even worse of glucocorticoid therapy. Fundus manifestations include optic disc swelling with peripapillary hemorrhage or neuro-retinitis, and the feature of concurrent uveitis. When these patients first visit ophthalmic clinics, they often lack signs of systemic infection, thus it is easy to misdiagnose them as other types of optic neuropathy and mistakenly treat them. In particular, high-dose glucocorticoid therapy can lead to very serious consequences. Therefore, how to correctly diagnose infectious and infection-related optic neuritis in the early stages are very important for ophthalmologists and need to be seriously kept in our mind.
The morbidity and mortality of pulmonary infection are high among infectious diseases worldwide. Rapid and accurate etiological diagnosis is the key to timely and effective treatment. Metagenomic next-generation sequencing (mNGS) technology has brokenthrough the limitations of traditional pathogenic microorganism detection methods and improved the detection rate of pathogens. In this paper, the application and advantages of mNGS technology in the diagnosis of bacteria, fungi, viruses and mixed infections in the lungs are analyzed, and the challenges and breakthroughs in RNA detection, wall breaking of firmicutes and host DNA clearance are described, in order to achieve targeted and accurate etiological diagnosis through mNGS, so as to effectively treat pulmonary infections.