摘要:目的:调查格列本脲的10年来不良反应情况为临床上合理使用格列本脲提供参考。方法:检索近10年(1999~2009)维普中文科技期刊数据库报道的格列本脲的不良反应文献,进行统计、分析。结果:格列本脲不良反应表现较多,机制复杂,最常见的是低血糖,其次是肝功能损伤。结论:临床上应该重视格列本脲的不良反应情况,针对不同病人合理用药。Abstract: Objective: To investigate the adverse reaction of glibenclamide in resent ten years so as to promote rational clinical glibenclamide Use. Methods: The adverse reaction reports in the vipdatabase (19992009) were summarized and investigated. Results:There exist complicated mechanism and lots of clinical symptoms of the adverse reaction of glibenclamide. The most common adverse reaction of glibenclamide is glycopenia. Conclusion: Great attention should be paid to adverse reactions of glibenclamide for rational drug use. Glibenclamide should be used according to physiological and pathological situation of patients.
Objective To analyze acupuncture resources in the Cochrane Database of Systematic Reviews (CDSR). Methods We identified acupuncture literature from CDSR (2008 year) electronically. W analyzed this literature by research time date, author, study contents, and conCochrane Library usions. Results We initially found 82 articles. Finally, we identified 67 systematic reviews. The number of acupuncture articles has increased all over the world with higher growth rate in China than overseas. The disease spectrum of acupuncture treatment increased widely, focusing on nervous system diseases and pain diseases. Eight articles (25.8%) definitely supported the efficacy of acupuncture. Twenty two articles (71%) considered the efficacy of acupuncture as uncertain owning to insufficient evidence. Just one article expressed that acupuncture treatment was ineffective according to current evidence.
Objective To provide references for production and dissemination of evidence in the fields of medical emergency management, treatment, and prevention of epidemics after May 2008 Wenchuan earthquake by systematically reviewing, analyzing, and comparing quake related papers in medical journals. Methods We systematically searched MEDLINE and CBM (Chinese Biomedical Literature) databases (range: from inception to Sept. 2009). Quake related papers were imported into EndNote software, checked for duplication, and categorized by predefined standards. Descriptive statistical analysis was performed by SPSS 13.0. Results There were relatively fewer quake related articles globally before the occurrence of the Wenchuan earthquake, and the quantity of papers in MEDLINE was four times than that in CBM. In contrast, the quantity of Chinese quake articles increased rapidly after Wenchuan earthquake, peaking in Aug. 2008 at 6.9 times the average during the 50 years before the quake. The quake related papers in CBM appeared in 378 journals covering a diverse range of subject matter. Meanwhile, there was little change in the quantity of quake related articles in MEDLINE database. Conclusions The effort of producing and disseminating Wenchuan earthquake related medical research has been effectively organized and conducted in a scientific and timely manner, producing the largest in number of quake related medical papers in human history. It has provided first-hand guidance for disaster medical relief around the globe. We should strengthen the systematic construction of disaster medicine, and make an effort to summarize and disseminate evidence in the fields of rehabilitation, system reestablishment, and prevention of epidemics.
【摘要】 目的 探讨非诺贝特致药品不良反应（ADRs）的一般规律和特点。 方法 检索PubMed（1978年-2009年8月）、中国期刊全文数据库CNKI（1980年-2009年8月）、中国生物医学文献数据库CBMDise（1980年-2009年8月）非诺贝特所致ADRs文献，进行统计、分析。 结果 非诺贝特致ADRs多发生在gt;40岁年龄段，与性别无显著关联；64例ADRs主要涉及骨骼肌肉系统、消化系统、泌尿生殖系统、过敏反应，及时处理者预后良好。 结论 临床上应重视非诺贝特所致ADRs，及时处理。【Abstract】 Objective To analyse the clinical features, correlation factors, preventions and cures of (adverse drug reactions, ADRs) caused by fenofibrate. Methods The cases of ADRs caused by fenofibrate were collected and analyzed from Pubmed (1978 - August 2009), CNKI (1980 - August 2009) and CBMDise (1980 - August 2009). Results Fenofibrate-induced ADRs were mostly seen in patients over 40 years old, but which was independent for sex. Totally, 64 ADRs were involved in the skeletal musculature system, digestive system, urinogenital system, and allergic response. The prognosis was favorable. Conclusion More attention should be given to patients with fenofibrate and ADRs should be treated as soon as possibile.
目的 了解国内医院品质管理圈（品管圈）活动的发展现况，为品管圈活动的进一步推广和研究提供依据。 方法 2012年2月－6月采用文献研究法，检索公开发表于国内学术期刊的有关品管圈活动的所有文献，并阅读分析全文。 结果 共收集符合要求的文献125篇，文献主要来源于我国东部地区、类型以回顾性分析为主，主题内容侧重护理质量与药事服务管理。 结论 我国医院品管圈活动发展迅速，涉及面广，但研究方法、研究内容如社区发展等方面仍亟待进一步加强。
目的:减少雷公藤多苷片引起的严重不良反应发生,保证用药安全。方法:通过检索雷公藤多苷片不良反应相关文献,筛选个案或典型病例报告,分析该类不良反应的临床特征。结果:64例个案病例中,不良反应累及器官或系统以血液系统为主、其次为生殖系统、泌尿系统和肝胆系统,大多较轻微,为一过性,停药后对症治疗可以恢复,但长期或大剂量服用可能导致严重的不良反应。结论:雷公藤多苷片所致不良反应与服药时间相关,可累积多个系统,建议根据病情严格控制服药剂量,并且在服药前和服药期间检查血、尿常规和肝肾功能。
目的 总结鲑鱼降钙素致不良反应的一般规律和特点。 方法 检索中国期刊全文数据库（CNKI）、万方数据库（WanFang）1994年1月－2012年3月鲑鱼降钙素所致不良反应的个案报道，按患者年龄、性别、给药途径、用药剂量、不良反应发生时间、临床表现症状、有无过敏史、治疗与转归等进行分类统计分析。 结果 15例不良反应包括皮肤系统、心血管系统、消化系统、神经系统和超敏反应，高年龄段和女性发生率较高。 结论 临床上应重视鲑鱼降钙素可致不良反应，坚持合理用药。
Objective Through assessing the quality of systematic reviews/meta-analyses conducted by hospital pharmacists in China, to learn relevant situations and to promote the development and application of evidence-based pharmacy in hospital. Methods The following databases such as CBM, CNKI, Wanfang Database, VIP, CMCI, The Cochrane Library, EMbase and PubMed were searched from the establishment date to April 15th, 2011, to collect all published systematic reviews/meta-analyses conducted by hospital pharmacists in China. Two reviewers independently extracted the published information according to the inclusive and exclusive criteria, and assessed the methodology and reporting quality of the included literatures with OQAQ and PRISMA. Disagreements were discussed or resolved by the third reviewer. Data analysis was conducted by using SPSS17.0 software. Results Two hundred and sixteen Chinese literatures (including 40 on traditional Chinese medicine), and 15 English literatures were identified. The number of literatures has increased rapidly since 2008. Beijing and Sichuan were the top 2 districts in the number of literatures. All of the included literatures were published in 62 magazines sponsored by 87 hospitals, such as China Pharmacy, and Chinese Journey of Evidence-Based Medicine. The total downloads of Chinese literatures were 14346, and the total citations of all literatures were 154. The methodology and reporting quality of the randomized controlled trials (RCTs) involved in 220 systematic reviews/meta-analyses literatures were assessed, which showed the highest and lowest scores of methodological quality were 6 and 3, respectively, and the average score was 4.27±0.55. The highest and lowest scores of reporting quality were 22.5 and 9, respectively, and the average score was 16.49±2.98. Conclusion Although the evidence-based pharmacy in hospital begins late in China, it develops rapidly, and offers lots of evidence to policy decision, guidelines and rational drug use. However, there is still room for improvement of the methodology and reporting quality in future reviews.
Objective To explore the characteristics of articles related to Evidence-based Nursing (EBN) and to identify the problems and difficulties encountered by clinical nurses when they were engaged in evidence-based practice in China.Methods We searched for articles published in 6 nursing journals in China from 2000 to early 2006, and classified, investigated and analyzed the retrieved articles. Results Research on EBN has been changing from explaining theories and methods to applying research results in nursing practice. Among articles on clinical application, 90.9% did not describe the methods and search strategy used; 63.6% did not specify the sources of the evidence applied in practice; 93.9% did not describe the methodological quality of the evidence; only 6.1% used the results of systematic reviews or randomized trials to guide clinical practice; and 72.7% did not use effective evaluation methods to identify the nursing outcomes after applying evidences in clinical practice. Conclusions The quality of EBN related articles needs to improve further. Nurses should learn more about the knowledge and skills associated with EBN so as to improve the quality of nursing practice and of academic articles on EBN
ObjectiveTo investigate the current research status and its developing trend of Crohn’s disease (CD) in Chinese journals in the past 40 years, and to provide reference for future research on CD.MethodsWith “Crohn’s disease” as the retrieval word, the literature about CD published from January 1978 to December 2017 were retrieved in the SinoMed database. The distributions of publication dates, journals, research institutions, and regions of literature were analyzed by EndNote, Excel, MySQL, and GraphPad Prism softwares.ResultsA total of 2 140 papers matched the searching criteria, including 1 391 papers published in the core journals. The number of papers increased by year, especially in the past 20 years, the growth rate of the total number of papers every 5 years was 96.67%, 202.54%, 85.15%, and 29.35%, respectively. A total of 152 papers met the criteria of evidence-based documents, and the proportion of evidence-based articles in the total papers every 5 years was 2.54%, 3.92%, 4.69%, and 12.16%, respectively. In the respect of region distribution of literature, the first addresses of 1 060 papers were in East China, accounting for 50.36% of the total number of papers. Jiangsu Province, Guangdong Province, Shanghai, Zhejiang Province, and Beijing had published a total of 1 257 papers, accounting for 59.71% of the total number of papers. In our research field, most of the studies were conducted by teaching hospitals.ConclusionsIn the past 40 years, the output of research on CD increased significantly in China. The proportion of evidence-based articles has increased, while the number of evidence-based research still needs to be improved. The regional distribution of literature was unbalanced, and teaching hospitals played a vital role in the research field.