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find Author "李辉" 49 results
  • Some thoughts on immunotherapy for esophageal squamous cell carcinoma

    Great progress has been made in immunotherapy for esophageal squamous cell carcinoma in recent years. However, for thoracic surgeons, immunotherapy is still a new thing and they lack enough experience. Therefore, this paper attempts to discuss some hot issues of immunotherapy, including the indications, side effects, clinical efficacy and evaluation of efficacy. The author hopes that this article will help and attract the attention of thoracic surgeons.

    Release date:2021-03-05 06:30 Export PDF Favorites Scan
  • 管状胃技术在食管重建中的应用

    Release date:2016-08-30 06:01 Export PDF Favorites Scan
  • Interpretation of guideline for the prevention and management of perioperative venous thromboembolism in thoracic malignancies in China (2022 version)

    Patients with thoracic malignancy have a high incidence of perioperative venous thromboembolism (VTE), but its onset is insidious, often asymptomatic or atypical, and is easily overlooked. Early identification and standardized prevention of VTE can effectively reduce the risk of VTE. "Guideline for the prevention and management of perioperative venous thromboembolism in thoracic malignancies in China (2022 version)" has been officially released recently. This article closely follows the context, significance, core implications, and the impact of future VTE prevention in thoracic surgery. It is hoped that through our joint efforts, we can reduce the incidence of perioperative VTE and mortality of thoracic surgery, and strive to improve the long-term survival of patients with lung cancer and esophageal cancer.

    Release date:2022-10-26 01:37 Export PDF Favorites Scan
  • 单孔胸腔镜肺手术的扶镜体会与思考

    Release date:2018-11-27 04:47 Export PDF Favorites Scan
  • Correlation between osteoprotegerin / receptor activator of nuclear factor-κB ligand ratio and sepsis-related acute lung injury

    Objective To investigate the changes in osteoprotegerin (OPG) / receptor activator of nuclear factor-κB ligand (RANKL) ratio in sepsis-associated acute lung injury (SA-ALI) and the role of regulation of this ratio on the inflammatory response in SA-ALI. Methods Eighteen C57BL/6 male mice were randomly divided into sham operation group, cecal ligation and perforation (CLP) group and RANKL group, with 6 mice in each group. Before the experiment, the RANKL group was intraperitoneally injected with 5 μg (0.2 mL) of recombinant RANKL antibody, whereas both the sham operation group and the CLP group were intraperitoneally injected with a volume-matched normal saline. One hour later, the sham operation group underwent only abdominal exploration and repositioning, while the other groups underwent the CLP surgery to induce the SA-ALI model. After 24 h of modelling, all mice were sacrificed and samples were collected. Pathological evaluation of lung tissues was performed by haematoxylin-eosin staining; enzyme-linked immunosorbent assay was used to detect serum concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β; while the mRNA and protein expression of OPG and RANKL, along with their ratio values, were detected by real-time polymerase chain reaction for quantitative analysis and protein immunoblotting. Results The SA-ALI mouse model was successfully established. Compared with the sham operation group, mice in the CLP group showed disturbed alveolar structure, obvious alveolar and interstitial haemorrhage and inflammatory cell infiltration, elevated serum levels of IL-6, TNF-α and IL-1β (P<0.05), significantly increased mRNA and protein expression of OPG and elevated OPG/RANKL ratio in lung tissue (P<0.05), whereas RANKL mRNA and protein expression was significantly decreased (P<0.05). Compared with the CLP group, the pathological damage of lung tissue in the RANKL group was reduced, the infiltration of alveolar and interstitial inflammatory cells was significantly improved, and the alveolar structure and morphology were more regular, with lower serum levels of IL-6, TNF-α and IL-1β (P<0.05), significantly lower mRNA and protein expression of OPG and OPG/RANKL ratio in lung tissue (P<0.05), and significantly higher mRNA and protein expression of RANKL in lung tissue (P<0.05). Conclusion The alteration of OPG/RANKL ratio may be related to the pathophysiological process of SA-ALI, and the decrease in its level may reflect the attenuation of the inflammatory response in SA-ALI.

    Release date:2025-08-26 09:30 Export PDF Favorites Scan
  • COMPARISON OF THE CLINICAL EFFECT OF COMPLEX TRANSPLANTATION WITH HETERGENEOUS ACELLULAR DERMAL MATRIX (ADM) AND HETEROCATAL ADM

    Objective To explore the shortterm clinical effects of complex transplantation among the acellular dermal matrix(ADM) of heterogenic or heterocatal and autogenic split on the burnt wound as to find out a permanent substitution for the treatment on full skin thickness defect without scar. Methods Two kinds of ADM were used on the 18 patients with full thicknessburn wound through complex transplantation with autogenic splits. The patients with medialthickness autograft was used as control group. Survival rate was obtained 2 weeks after operation; contraction rate and the scores of Vancouver burn scale were obtained 8 weeks after operation. Results No significant difference was observed in survival rate among the three groups 2 weeks after operation(P>0.05); no significant difference was observed in contraction rate of autografts and scores of Vancouver burn scale among the three groups 8 weeks after operation(P>0.05). Conclusion ADM of heterogenic and ADM of heterocatal have similar effect on the reconstruction of skin, so the piglet ADM made in this way could be used as a substitution.

    Release date:2016-09-01 09:27 Export PDF Favorites Scan
  • 胸部开放伤后海水浸泡对实验犬呼吸功能的影响

    目的 探讨胸部开放伤后海水浸泡所致呼吸功能障碍的病理生理特点,为研究早期救治方案提供依据。方法 实验犬致伤后随机分为对照组(n=10)和海水浸泡组(n=10)。海水浸泡组:犬于致伤后置入人工配制的海水中,于致伤前及入海水后即刻、30分钟和45分钟取动脉血测定血气分析变化,同时监测通气功能和换气功能变化。对照组:不浸泡海水,于致伤前、致伤后即刻、30分钟、45分钟、1小时、2小时、3小时和4小时进行监测,处理同海水浸泡组。 结果 海水浸泡组的呼吸功能衰竭明显重于对照组,表现在严重的低氧血症和高碳酸血症,而且出现的时间早。对照组低氧血症的主要原因是以通气/灌注比率失调为主的换气功能障碍,同时并存一定程度的限制性通气功能障碍;而造成海水浸泡组低氧血症和高碳酸血症的主要原因是以严重肺泡通气不足为主的通气功能障碍和肺内分流引起的换气功能障碍。 结论 胸部开放伤后海水浸泡组与对照组所造成呼吸功能障碍的机制有所不同,前者可造成严重的Ⅱ型呼吸衰竭,对生命威胁更大

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • Treatment of achalasia by transthoracic Heller myotomy with a small incision

    Objective To review the clinical experience of Heller myotomy for treatment of achalasia through a small thoracotomy. Methods Twenty-five patients with achalasia (9 moderate, 16 severe) underwent Heller myotomy without concomitant antireflux procedure through a small incision. A left thoracotomy was carried out through either the seventh or eighth intercostals space. The length of skin incision was 6 to 8 cm. Results There was no hospital death and severe postoperative complications. The mean operating time was 50 minutes. Mean hospital stay was 10 days. There was one intraoperative perforation and repaired successfully. All patients reported good to excellent relief of dysphagia and no symptom of gastroesophageal reflux after surgery. Eight patients were subsequently studied with a 24-hour esophageal pH monitoring and no evidence of pathologic reflux found. Conclusions Transthoracic Heller myotomy with a small incision is effective and safe method for treatment of achalasia with minimal invasion, quick recovery, less postoperative complication and shorter hospital stay. Proper extent of the myotomy may decrease the risk of subsequent gastroesophageal reflux in the postoperative period.

    Release date:2016-08-30 06:28 Export PDF Favorites Scan
  • 右位主动脉弓致食管外压性狭窄一例

    Release date:2016-08-30 05:59 Export PDF Favorites Scan
  • 国产与进口消化道吻合器的临床应用

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
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