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find Keyword "特发性" 123 results
  • Developments in researches on acute exacerbation of idiopathic pulmonary fibrosis

    Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is defined as an acute and clinically significant respiratory deterioration characterized by evidence of new, widespread alveolar abnormality. In the past, AE-IPF was considered to be idiopathic, which was hard to be prevented and its prognosis was hard to be obviously improved; the latest researches have shown that AE-IPF can be triggered by known causes, including pulmonary infection, aspiration, etc. This review summarizes the etiology or risk factors, treatment and prevention of AE-IPF according to the latest researches.

    Release date:2018-01-23 02:34 Export PDF Favorites Scan
  • RESEARCH ADVANCEMENT OF THREE-DIMENSIONAL CORRECTION TECHNIQUES OF IDIOPATHIC SCOLIOSIS

    Objective To elucidate the new development and effects of three-dimensional correction techniques of idiopathic scol iosis (IS). Methods The related home and abroad l iterature concerning three-dimensional correction techniques of IS was extensively reviewed. Results With more and more attention to three-dimensional correction of IS, all kinds of surgery and developed techniques of correction are applied to the correction of IS. The effects of three-dimensional correction of IS are satisfied. Conclusion With more knowledge about IS and more developed theory of correction, more safe and effective techniques of correction is therefore the hot spot for future study.

    Release date:2016-08-31 04:23 Export PDF Favorites Scan
  • 成人特发性肺含铁血黄素沉着症一例

    患者女性,49岁。因“间断胸闷、咳嗽、咯血1+个月”,于2006年7月15日入院。曾在当地医院拟诊为“肺结核,肿瘤性病变待排,缺铁性贫血”,给予相应治疗无效。既往体健,无过敏史、寄生虫接触史及家族遗传史。体格检查:体温36.5 ℃,脉搏70次/min,呼吸22次/min,血压16.5/11.5 kPa,SaO2 97%(未吸氧);轻度贫血貌,皮肤黏膜、浅表淋巴结及心肺均未见异常,腹平软,肝右肋下2 cm,质中偏软,无压痛,脾肋下未及。

    Release date:2016-08-30 11:35 Export PDF Favorites Scan
  • EFFECTS OF MECHANICAL STIMULATION ON EXPRESSION OF AUTOANTIGENS IN MYOBLASTS

    Objective To explore the effects of mechanical stimulation on the expression of autoantigens in myoblasts. Methods According to different processing methods, C2C12 cells were divided into the experimental group and control group; the experimental group was divided into 4 subgroups: 2-, 4-, and 6-day and 1-day stretch groups. In 2-, 4-, and 6-day stretch groups, mechanical loading was added on the C2C12 cells at a stretching frequency of 0.25 Hz and cellular deformation amplitude of 10%, 2 hours a day for 2, 4, and 6 days respectively by Flexercell 5000 strain unit, and at a stretching frequency of 1 Hz and cellular deformation amplitude of 15% for 1 hour in 1-day stretch group. In the control group, the cells were routinely cultured for 1, 2, 4, and 6 days (1-, 2-, 4-, and 6-day control). The cells were observed by inverted phase contrast microscope. The cell proliferation was detected by flow cytometry; the expressions of autoantigens were detected by Western blot method, including the Ku/the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), U1-70 (A part of ATP-dependent DNA helicase II), histidyl tRNA synthetase (HRS), and Mi-2 (reconfigurable components deacetylase complexes of NuRD). Results The exfoliated cells were found in 1-day stretch group, but no exfoliated cell was seen in the control group for 1-day culture. The cells proliferated more obviously in 2-day stretch group than in the control group for 2-day culture; cell differentiation was found in 4-day stretch group, and cell fusion in 6-day stretch group, which were similar to those in the control group for 4- and 6-day culture. After single stretching, cell apoptosis was found in 1-day stretch group, showing no significant difference in the relative DNA proliferation index (DPI) when compared with DPI of control group for 1-day culture (t=0.346, P=0.747). After cyclic stretching, DPIs of 2- and 4- day stretch groups were significantly increased when compared with those of the control group for 2- and 4-day culture (P lt; 0.05), but no significant difference was found between control group for 6-day culture and 6-day stretch group (t=1.191, P=0.303). Compared with the control group for 2-day culture, the relative protein expression of autoantigens (DNA-Pkcs, Mi-2, HRS, and U1-70) in 2-day stretch group decreased significantly (P lt; 0.05), but no significant difference was found between control group for 4-day culture and 4-day stretch group (P gt; 0.05). The relative protein expressions of autoantigens in 4-day stretch group significantly increased when compared with those of 2-day stretch group (P lt; 0.05), but the relative protein expressions of autoantigens in the control group for 4-day culture significantly decreased when compared with those of the control group for 2-day culture (P lt; 0.05). Conclusion Short-term mechanical stimulation can inhibit the expressions of autoantigens in myoblasts, but with the time prolonging, cell differentiation and fusion and adaptation to mechanical stimulation would result in diminished inhibitory effect.

    Release date:2016-08-31 04:12 Export PDF Favorites Scan
  • Guidelines for diagnosis and treatment of Chinese medicine on idiopathic pulmonary fibrosis

    Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic and interstitial lung disease of unknown cause. It has a serious impact on people's health. Traditional Chinese medicine (TCM) has certain advantages in diagnosing and treating on IPF, which have been widely used in clinic. In order to improve the diagnostic and treatment level for IPF with TCM. The Internal Medicine Committee of World Federation of Chinese Medicine Societies organized and established a multidisciplinary background working group. The document was formulated by referring to the formulation method and process of clinical practice guidelines, which are based on the best evidence and the opinions of clinical physicians and patients. Physicians can use this guideline to make clinical decisions.

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  • 特发性黄斑视网膜前膜的视功能

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • 吡非尼酮治疗特发性肺纤维化: 我们拥有多少证据?

    特发性肺纤维化( idiopathic pulmonary fibrosis, IPF) 为原因不明, 局限于肺, 以普通型间质性肺炎( usual interstitialpneumonitis, UIP) 为病理特征的慢性进行性发展的纤维化性间质性肺疾病。该病预后不良, 现无有效治疗药物[1] , 寻找有效治疗IPF的药物始终是该研究领域的热点之一。迄今已有诸多针对肺纤维化发病机制的基础研究成果, 并陆续转化为新的研究药物[2] 。IPF 临床中心协作网的建立使数以百计的IPF患者比较快地入组参加新药物临床试验, 并顺利完成了多项高质量的双盲、随机、安慰剂对照临床试验, 有力推动了IPF 治疗领域的进展。遗憾的是, 近几年已发表的多项临床试验结果[3-6] 令人失望。在挫折和期盼之中, 最新发表的吡非尼酮( pirfenidone) 治疗IPF临床试验结果[7] 为无药可治的IPF患者带来了一线希望的曙光。

    Release date:2016-08-30 11:53 Export PDF Favorites Scan
  • 视网膜下内引流治疗特发性息肉样脉络膜血管病变引起的高眼压症2例

    Release date:2025-07-17 09:24 Export PDF Favorites Scan
  • Efficacy and Safety of Coenzyme Q10 for Idiopathic Oligoasthenoteratozoospermia: A Meta-analysis

    ObjectiveTo systematically review the efficacy and safety of CoQ10 for idiopathic oligoasthenoteratozoospermia (iOAT). MethodsWe searched databases including PubMed, EMbase, MEDLINE, The Cochrane Library, CBM, CNKI, VIP and WanFang Data from inception to May 31th 2016 for randomized controlled trials (RCTs) on CoQ10 in the treatment of iOAT. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. ResultsSeven RCTs involving 803 patients were included. The results of meta-analysis showed, compared with the control group, the CoQ10 group could significantly increase sperm concentration (MD=3.37, 95%CI 0.68 to 6.05, P=0.01), the number of A grade spermatozoa (MD=5.06, 95%CI 3.84 to 6.28, P < 0.000 01), the number of A+B grade spermatozoa (MD=7.72, 95%CI 4.19 to 11.26, P < 0.000 1), the rate of morphologically normal sperm (MD=1.89, 95%CI 0.63 to 3.16, P=0.003) and sperm coenzyme Q10 level (MD=40.02, 95%CI 24.73 to 55.31, P < 0.000 01), while not improve the levels of serum sex hormone (FSH: MD=–3.48, 95%CI –5.17 to –1.79, P < 0.000 1; LH: MD=–3.23, 95%CI –7.55 to 1.08, P=0.14; T: MD=0.45, 95%CI –3.31 to 4.20, P=0.82). No significant difference in adverse event was noted between two groups. ConclusionThe evidence suggests that CoQ10 as empiric medical therapy for iOAT with low non-serious adverse event associated, may improve sperm concentration and percent sperm motility. However, the strength of evidence is low due to high risk of bias of the included studies. More rigorous studies are needed to verify the above conclusion.

    Release date:2016-10-02 04:54 Export PDF Favorites Scan
  • Efficacy and Safety of Pirfenidone in Treatment of Idiopathic Pulmonary Fibrosis: A Meta-analysis

    ObjectiveTo evaluate the efficacy and safety of pirfenidone in patients with idiopathic pulmonary fibrosis. MethodsPubMed, Cochrane Library, CNKI, CBM, Wanfang, and VIP databases were searched for randomized controlled trials of pirfenidone as interventions for the treatment of idiopathic pulmonary fibrosis. According to the Cochrane system evaluation method, the methodological quality of included studies was evaluated and the effective data were extracted. The meta-analysis was performed with RevMan 5.2 software. ResultsSix studies were included with 1727 patients in total. Compared with placebo groups, pirfenidon could improve the changing rate of vital capacity at the end of the treatment[WMD=0.06, 95% CI (0.01, 0.12), Z=2.48, P=0.01; heterogeneity inspection χ2=1.03, P=0.31]. Pirfenidon could not improve the changing rate of lowest SpO2 in 6-minute walking test[WMD=0.82, 95% CI (-1.35, 2.98), Z=0.74, P=0.46; heterogeneity inspection χ2=8.90, P=0.003] and could not reduce the mortality[RR=0.62, 95% CI (0.37, 1.03), Z=1.85, P=0.06; heterogeneity inspection χ2=3.05, P=0.55]. The incidences of photosensitivity, dizziness, nausea, abdominal discomfort, joint pain, fatigue in pirfenidone group were more frequent than those in placebo group. ConclusionsBecause of lack of enough eligible studies and defects in design and reporting data in the studies, this meta-analysis can not evaluate pirfenidone's long-term efficacy and safety. Hence, the existed clinical evidences can't support pirfenidone to be the treatment of IPF medication.

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