Determination of free radical has been done in the fibrous capsules with electron spin resonaee (ESR). The results showed that there was a marked production of oxygen free radical, and the superoxide dismutase could scavenge it effectively. The author discussed the oxygen relationship of free radicals with the collagen synthesis in the fibrous capsule.
We determined superoxide radical in ischemia-reperfu-sion to skin flaps by electron spin resonance and observed itseffect to skin flap survival. The experimental results showthat superoxide radical arise in ischemia-reperfusion. By per-fusion with superoxide dismutase,as free radical scavengers,significantly improved flap survival rate over controls. Basedon experimental date, the pathology mechanisms of skin flapnecrosis is discussed.
The specimens were obtained from 7 fibrous capsules two years after mammoplasty with silicone prosthesis, and were examined by electron spin resonance (ESR) andmicroscope. The result showed that a marked quantities of oxygen free radical existed in the capsules and that the main pathological change was the infiltration of massive inflammatory cells and deposition of collagen. It was suggested that the fibrous capsule formation was concerned with the oxygen free radical. The origin of the oxygen free radical in mammoplasty with slicone was also discussed.