From jan.1984 through dec.1991,65 cases of hand skin defects were primarily repaired by podicled groin flap. Four of the 65 cases had skin defects on both sides of the palms and dorsal aspot of the hands which were treated by the Y-shaped hypogastric groin flap .Five easec had thumb loss in which the lxdicled groin tubed flap was used to reconstruct the thumb.The time of division of the pedicles ranged from 14 to 28 days(averaged 16 days).All flape survived after division of the podicl...
Since 1987, One hundred and fifty-four patients suffered from alopecia, neck and facial scar, and nasal defect had been treated with skin soft tissue expansion. The incidence of complication was decreased markedly, compared to previons report which was 11.7%. Two cases of this group were given up this procedure. The lessous learned from these case were as following. Strictly evaluated the case according to the indication, examined the expander carefully, improved the techniques to inbed the expander and infilled the sailine, those of which could obtain satisfactory result.
An in vitro experiment showed that the skin expanders were permeable to metronidazole and procaine. Twenty kidney shaped skin expanders were divided into four groups. Group 1. 100ml 0.2% metronidazole solution was injected into the expanders and the expenders were immersed in a flask filled with 100ml saline solution, and then were placed in a hermetically sealed glass chamber; Group 2.the whole procedure was the same as that of Group 1 except the expander was previously boiled in water for 30 minutes; Group 3. 100 ml 2% procaine was injected instead of metronidazole, other step was the same as that ofgroup I; and Group 4. the whole procedure was the same as that of Group 2 except the solutioninjected was 2% procaine. The concentration of metronidazole and procaine in the surrounding saline was measured at 1st, 2nd, 4th, 16th, 24th, 48th, 72nd 120th hours. The rate of diffusion of a drug was highest at 2 and 4 hous. The rate of diffusion was inversely proportional to its molecular weight, i.e., the smaller the molecular weight the greater the permeability. In view of this, during the process of expansion, metronidazole and procaine would diffuse out of the expander which might be beneficial for preventing infection and controlling pain.
OBJECTIVE: To evaluate the application of skin and soft tissue expansion in the treatment of deformity due to extensive severe burn injury and repair of severe deep electrical burned scalp and skull with fresh wound. METHODS: From 1988, 83 cases of application of skin and soft tissue expansion were reported. In those patients with deformity due to severe burn of large area and with whole nasal defect, soft tissue expander was used under the forehead skin graft and venter frontalis, followed by reconstruction of nose with the expanded vascularized skin flap and carved cartilago costalis as nasal frame. In patients of severe deep electrical burned scalp and skull with fresh wound, skin and soft tissue expansion were used to repair the wound simultaneously with scalp burn alopecia, anesthetics and antibiotics injected into the extracapsular space of the expander in case of pain and infection. RESULTS: All of the cases were successfully treated with little pain and minimized infection. CONCLUSION: Skin and soft tissue expansion in a safe and reliable measure in the treatment of deformity due to extensive severe burn injury and repair of severe deep electrical burned scalp and skull with fresh wound.
Soft tissue expander has been improved to perfection in recent ten years. Many excellent works have been accomplished for the patients who suffered from either soft tissue malformation or defects following traumatism, infection or benign tumors. But the reconstruction of soft tissue defects cause by malignant tumor hasbeen less studied.Four patients suffering from malignant tumour localized in the scalp and face, 1women and 3 men ranging from 65 to 75 years of age, have been operated on since1986. Their major deficits have been reconstructed with radican tissue expander, by the flap of the same colour and texture and also, similar thickness and sensation. There is no relapse in all the patients operated on reported until today.The surgical technique was discribed. The clinical results and the indication of tissue expander in the surgical treatment of malignant tumour are discussed.
As the largest barrier organ in the human body, once skin defect occur, it not only affects appearance but also cause clinical problems such as infections. Traditional skin defect repair methods, such as autologous skin transplantation and allogeneic skin transplantation, have shortcomings such as limited donor sources, potential immune rejection, and limited repair effects, and are difficult to meet the individualized treatment needs of complex wounds. Bioprinting technology, as a breakthrough approach in tissue engineering in recent years, can accurately control the spatial distribution of seed cells and biomaterials within scaffolds based on digital models, achieving personalized biomimetic structure of skin tissue. This article aims to summarize the application and research progress of bioprinting technology in skin tissue engineering, providing a theoretical basis for its further clinical application.