A acute partial obstructive hepatocholangitis model by selective ligation and injection of E coli into left hepatic bile duct was successfully founded in rat. Using parameters including mortality, mitochondrial glutamic oxalacetic transaminase and ornithine carbamoytransferase activity, pathological observation and blood culture of bacteria, we evaluated the model. The authors emphasize that this models is superior to the wole-bile-duct-challenged cholangitis model, which is characterized by liver injury.
Objective To evaluate the clinical value of ureteroscope in cholelithiasis treated by laparoscopic surgery. Methods The clinical data of 36 patients admitted because of hepatolithus with ureteroscope combination in laparoscopic surgery from February 2007 to September 2009 in Guidong People’s Hospital of Guangxi were analyzed retrospectively. Results In 33 cases, stones were removed once by ureteroscope in laparoscopic surgery with residual stones (in 3 cases residual stone were removed secondarily through T tube) and the other 3 cases were transferred to laparotomy forcedly due to bleeding of biliary duct and vessels of porta hepatis and tearing of bile duct. During operation, blood loss was 30-280 (94.51±54.70) ml; operation time was 110-260 (147.22±48.45) min; recovery time of bowel movement was 1-3 (2.03±0.76) d; postoperative hospitalization time was 6-13 (7.12±1.65) d (some discharged with T tube); the time of patients of T tubes pulled out was 28-45 (38.92±6.52) d. Bile leakage happened in 1 case and infection of biliary tract in 1 case, no complications such as biliary stricture or bile duct bleeding were found after operation. Conclusions Treatment of intrahepatic bile duct or a single extra-hepatic sand-like stones with ureteroscopy usage in laparoscopic surgery is feasible and less invasive. It is a minimally invasive treatment for intra- or extra-hepatic stones due to rapidly postoperative rehabilitation.
Hepatolithiasis is a common and frequently-occurring disease in China. Its condition is complex and variable, making diagnosis and treatment challenging. To standardize the diagnosis and treatment of hepatolithiasis, experts in hepatobiliary surgery from Hunan Province jointly discussed, drafted, and published the “Comprehensive Diagnosis and Treatment Expert Consensus on Hepatolithiasis in Hunan (2024 Edition)”, providing a more solid basis and more comprehensive guidance for the standardized diagnosis and treatment of hepatolithiasis. To help hepatobiliary surgeons better understand and apply this consensus, we provide a detailed interpretation of its key points and innovations.
目的探讨减少肝胆管结石术后残余结石的方法，降低术后结石残余率。方法回顾分析112例肝胆管结石术后残余结石病例的胆管造影X线片，观察残余结石的分布情况。结果胆总管残余结石者11例（9.8%），左肝管残余结石者15例（13.4%），右肝管残余结石者34例（30.4%），尾叶支肝管残余结石者20例（17.9%），左右肝管、胆总管残余结石者32例（28.6%）。结论合理选择手术方案是降低肝胆管结石术后残余结石的关键。
ObjectiveTo study the efficacy and safety of early laparoscopic cholecystectomy with percutaneous transhepatic gallbladder drainage (PTGBD) in the treatment of elderly patients with high risk moderate acute cholecystitis.MethodsThe clinical data of 218 elderly patients with high risk moderate acute cholecystitis admitted to Department of Hepatobiliary Surgery in Dazhou Central Hospital from January 2015 to October 2019 were retrospectively analyzed, including 112 cases in the PTGBD combined with early LC sequential treatment group (sequential treatment group) and 106 cases in the emergency LC group. In the sequential treatment group, PTGBD was performed first, and LC was performed 3–5 days later. The emergency LC group was treated with anti infection, antispasmodic, analgesia, and basic disease control immediately after admission, and LC was performed within 24 hours. The operation time, intraoperative blood loss, conversion to laparotomy rate, postoperative catheter retention time, postoperative anal exhaust time, postoperative hospitalization time, hospitalization cost, incidence of incision infection, and incidence of complications above Dindo-Clavien level 2 were compared between the two groups to evaluate their clinical efficacy and safety.ResultsAll patients in the sequential treatment group were successfully treated with PTGBD, and the symptoms were significantly relieved within 72 hours. There were significant differences in the operation time, intraoperative blood loss, conversion to laparotomy rate, postoperative tube retention time, postoperative anal exhaust time, postoperative hospitalization time, incidence of incision infection, and the incidence of complications above Dindo-Clavien level 2 between the two groups (P<0.05), which were all better in the sequential treatment group, but the hospitalization cost of the sequential treatment group was higher than that of the emergency LC group (P<0.05). There were no cases of secondary operation and death in the 2 groups. After symptomatic treatment, the symptoms of all patients were relieved, without severe complications such as biliary injury and obstructive jaundice. All the 218 patients were followed up for 4–61 months, with an average of 35 months. During follow-up period, 7 patients in the sequential treatment group had postoperative complications, and complications were occurred in 13 patients in the emergency LC group.ConclusionPTGBD is the first choice for elderly high risk moderate acute cholecystitis patients with poor systemic condition and high risk of emergency surgery, but it has the disadvantage of relatively high medical cost.
这个题目，讨论的文章已经很多，现只就几个问题谈一些个人看法。1我国多见的肝胆管结石病有许多特点1.1西方国家极少见原因何在？除感染因素早已确定外，可能有代谢因素和基因等其它问题。1.2病变部位可在肝内各处，较多见于左外叶。可能由于肝内胆管与其下游胆管间的交角较锐，胆流相对迂滞，固形物如结晶颗粒，或异物如蛔虫尸皮等，较易停留。除左肝外，右肝后叶或某些其它部位胆管支也有相似情况。我们还发现畸形发育的右后叶肝管开口于左肝管者，其右后叶中存积结石。1.3胆道蛔虫病仍是主因结石绝大多数是含菌的，这与胆道寄生虫感染有关。除广东、香港等地人们多吃鱼生致中华肝蛭病外，大陆多数地区是由肠蛔虫引致的胆道蛔虫病，都是肠属菌脓性胆管炎。我们还发现，人蛔虫与猪蛔虫不但形态无区别，它们的组织液成分也无区别，故可能交叉感染。我国各地特别是农村几乎家家养猪，这给预防带来很大困难。1.4胆管炎很难净化结石中含菌，有残石即不断感染。结石清除后，管壁的炎性反应伴腺体中残留的细菌将长期存在，以大肠杆菌为主，据文献报道可持续半年以上，很难清除。1.5病灶长期持续慢性炎症与急性发作反复交替，管壁增厚，管腔因结石存在而扩张，管口则常狭窄。受害区的肝组织逐渐萎缩，纤维化，成为一个包括结石、病变胆管和肝组织为一体的病灶。未病的邻近胆管和肝组织常为正常。病灶可能多数，甚至全肝多处分散存在。病灶较常位于肝内亚段胆管，可能的解释是蛔虫上入肝内时，纂到最细处，不能退出，死于其中。其后虫尸腐烂断落，大部可随胆汁流出，而在亚段中的虫尸未被排出者，日后便形成病灶。
目的 评价B超引导下经皮经肝胆囊穿刺引流术（PC）治疗老年急性重症胆囊炎的效果。方法 18例重症胆囊炎的老年患者接受了在局部麻醉下经皮经肝穿刺胆囊置管引流。结果 所有患者穿刺置管成功，无一例发生并发症，且症状及体征均于术后24～48 h明显改善。结论 PC是一种微创、有效、廉价、可靠的治疗老年急性重症胆囊炎的方法。