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Condition Judgement and Dynamic Observation of Acute Abdomen

目的 总结对急腹症在病情判断方面的经验。方法 回顾性分析310例急腹症患者的临床资料。结果 即时确诊211例，经短暂观察确诊54例，经手术探查确诊32例，未明确诊断但经保守治疗痊愈好转6例，误诊、漏诊7例，总确诊率为95.8%。结论 急腹症的病情判断和动态观察是明确诊断和及时治疗的前提。只有勤于实践并掌握正确的方法才能提高分析判断能力。

Treatment of Larynxderived Cough with Modified Zhisousan

目的：观察古方止嗽散加味治疗喉源性咳嗽的疗效。方法：采用加味止嗽散治疗喉源性咳嗽116例，并设西药对照组113例。结果：治疗组有效率87.3%，对照组有效率68.2%，两组比较有显著差异(Plt;0.01)。治疗组不良反应例数为零；对照组不良反应例数约占10.2%。结论：加味止嗽散具有疏风宣肺、清热解毒、利咽祛痰、益气养阴、扶正祛邪、抗病毒、抗菌、抗炎和增强免疫功能等功效，为治疗喉源性咳嗽的有效方药。

下肢骨折术后肺动脉栓塞治疗的临床观察

【摘要】目的回顾性总结下肢骨折并发肺动脉栓塞（PE）的诊治和转归情况,为临床预防、及早发现并及时治疗骨折并发PE提供参考。方法收集笔者所在科室近年收治的20例资料完整的骨折并发PE患者病历,回顾性分析其诊治方法及转归,总结防治策略。结果在20例患者中,2例住院期间因PE死亡,其余18例治愈出院随访至今效果满意。结论提高对PE的认识,是早期发现PE的前提,应对PE的最好措施是积极预防,特别是预防下肢静脉血栓形成。提高医生观察、判断病情的能力,争取治疗及抢救时机可减少PE的病死率。

甲状腺腺瘤122例病理组织学观察

目的 探讨甲状腺腺瘤诊断的准确性。 方法 2002年1月-2008年12月对122例甲状腺腺瘤标本，经常规石蜡制片，利用光镜进行组织形态学观察。 结果 122例甲状腺腺瘤中良性113例，占92.62%，恶性9例，占7.38%。 结论 主要根据肿瘤组织形态学进行回顾性分析，统一对诊断的认识，提高对组织形态学诊断的准确性。

输血相关性急性肺损伤观察护理一例

美罗华治疗非霍奇金淋巴瘤的观察及护理

目的:探讨美罗华治疗非霍奇淋巴瘤(NHL)时的观察及护理。方法:通过28例非霍奇金淋巴瘤患者应用美罗华,观察用药过程中的不良反应,采取护理对策。结果:通过用药前的处理及控制输液速度的方法,药物不良反应明显减少,副作用及时得到控制。28例患者只有3例第一次输注时出现发热、寒颤。结论:掌握正确的给药方法,严密监测生命体征,及时发现不良反应及时处理,将药物的不良反应降至最低。

N VITRO STUDIES ON TISSUE ENGINEERED INTERVERTEBRAL DISC

Objective To investigate the feasibility oftissue engineered intervertebral disc for regeneration of discs. Methods A three-dimensional porous poly(L-lactic-co-glycolic acid) (PLGA) scaffold was fabricated by temperature induced phase separation method. Human fetal disc cells were isolated and cultured in vitro. The disc cells labeledwith a PKH-26 fluorescent dye were seeded into a threedimensional porous scaffold. The proliferation of disc cells with PKH-26 fluorescent labels was assessed by using MTT uptake, laser fluorescence microscopy and SEM. Results Human fetal disc cells displayed a polygonal shape in primary monolayer culture. A regular arrangement and microtubules orientationstructure scaffold with 50-300 μm in diameter was fabricated by thermal-induced phase separation technique. MTT uptake and fluorescent microscopy examination indicated that the seeded disc cells were viable and showed proliferation activity within a porous scaffold. Conclusion The above findings support potential applications of tissue engineered disc in treatment of disc degenerative diseases.

Effects of breastfeeding on reducing the risk of overweight and obesity among offspring exposed to intrauterine hyperglycemia: a meta-analysis

ObjectiveTo systematically review the effectiveness of breastfeeding duration and intensity in reducing the risk of overweight or obesity among offspring exposed to intrauterine hyperglycemia. MethodsThe PubMed, EMbase, Web of Science, CBM, WanFang Data, CNKI and VIP databases were electronically searched to collect observational studies on the associations of breastfeeding with the risk of overweight or obesity among offspring exposed to intrauterine hyperglycemia from inception to September 25th, 2021. Two reviewers independently screened the literature, extracted data and assessed the risk of bias of the included studies. Stata 16.0 software was used for the meta-analysis. ResultsA total of 12 657 participants from 13 observational studies were included. The results of meta-analysis showed that breastfeeding could reduce the risk of overweight or obesity among offspring exposed to intrauterine hyperglycemia (OR=0.67, 95%CI 0.53 to 0.84, P=0.001). Subgroup analysis revealed a protective effect of breastfeeding for both 1-6 months (OR=0.53, 95%CI 0.37 to 0.75, P<0.001) and ≥6 months (OR=0.56, 95%CI 0.46 to 0.69, P<0.001); however, breastfeeding shorter than one month was suggested to increase the risk of overweight or obesity (OR=2.15, 95%CI 1.41 to 3.27, P<0.001). ConclusionAvailable evidence suggests that breastfeeding for more than one month is effective in reducing the risk of overweight or obesity in offspring exposed to intrauterine hyperglycemia, and women with hyperglycemia should be encouraged to breastfeed their offspring for at least 1 month to achieve the effect. Due to the limited quantity and quality of the included studies, more high-quality studies are needed to verify the above conclusion.

Analysis of Clinical Medicine Observation of the First Imported Case of Mainland China Influenza A/H1N1 Influenza 115 Close Contacts

目的：通过对首例甲型H1N1流感密切接触者临床医学观察发现二代患者,为大规模临床医学观察积累经验和参考。方法：对首例甲型H1N1流感患者密切接触者115例的临床医学观察资料进行回顾性分析。结果：115例密切接触者中,有6人出现不同程度咽充血、咽部疼痛症状,其中1例为糖尿病患者、2例为高血压患者;1例左前臂疱疹,1例口腔溃疡,4例结膜充血;观察第3天1例出现精神抑郁,1例出现情绪激动;观察第4天2例多次要求提前解除隔离,多例关心何时解除隔离。七日医学观察期间115例密切接触者均无咽痛、咳嗽、鼻塞等症状,体温均正常,情绪稳定,未发现二代患者。结论：对甲型H1N1流感患者的密切接触者进行临床医学观察是必要的,有助于发现二代患者,疾控中心(CDC)采样与临床医学观察和心理干预的有效结合,给传染病医学观察提供宝贵的经验和有效的工作模式。

Histamine H2-receptor Antagonists Therapy and Risk of Hip Fracture: A Meta-analysis

ObjectiveTo evaluate the association between H2RA and the risk of hip fracture by performing a meta-analysis. MethodsWe searched CNKI, PubMed and EMbase from inception to September 19th 2016, to collect case-control studies or cohort studies reporting the risk of hip fracture with H2RA. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed using Stata 13 software. ResultsEleven studies involving 206 276 hip fracture cases were included. The result of meta-analysis showed that patients receiving H2RA therapy had approximately 1.12 times the risk of developing hip fracture compared with nonusers (OR=1.12 95%CI 1.02 to 1.24, P=0.022). Subgroup analyses by interval time indicated that the risk appeared greater with the continuous users (OR=1.11, 95%CI 1.01 to 1.24, P=0.039) whereas the discontinuous users was not significantly associated with hip fracture risk. ConclusionH2RA therapy may be associated with an increased risk of hip fracture. For patients with intermittent medication, the side effect may disappear by discontinuation of PPI use for at least 30 days, but the study did not find time-effect relationship or dose-effect relationship. Considering the limitations of this study, more rigorous clinical trials evaluating the potential side-effect of H2RA are needed.