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find Keyword "重症" 502 results
  • DYNAMIC MEASUREMENT AND SIGNIFICANCE OF ENDOTHELIN IN BILE AND PERIPHERAL VEINOUS BLOOD IN PATIENTS WITH ACUTE CHOLANGITIS OF SEVERE TYPE

    Objective To evaluate the relationship between endothelin (ET) in bile and peripheral blood with systemic and hepatobiliary injury in patients with acute cholangitis of severe type (ACST). Methods ET, ALT and total bilirubin in bile and peripheral veinous blood of 25 patients with acute cholangitis of severe type (ACST) were detected during operation, one week and two weeks after operation. Results The contents of ET, ALT and total bilirubin were significantly lower on 7-day and 14-day after operations as compared with that during operations (P<0.05 and P<0.01). The concentration of ET in peripheral veinous blood paralleled with that in bile. Conclusion This suggests that ET is tightly related with the pathologic process of ACST. So, in patients with ACST, the dynamic measurement of ET in peripheral veinous blood can be an index for judging the degree of pathological damage either to the hepatobiliary or systemic systems.

    Release date:2016-09-08 01:59 Export PDF Favorites Scan
  • Management of Acute Severe Cholangitis

    【摘要】目的 探讨急性重症胆管炎(ASC)患者的手术时机、治疗方式的选择以及患者围手术期的治疗。方法 回顾性分析156例ASC患者的临床资料。结果 治愈131例,死亡25例,总死亡率为16.0%。入院后行急诊手术者32例,术后死亡9例,死亡率28.1%; 入院后经支持治疗、纠正休克和酸碱失衡及抗感染治疗后再行手术者53例,死亡9例,死亡率为17.0%。行ERCP+乳头括约肌切开术治疗17例,行PTCD 治疗12例,行保守治疗42例。结论 对ASC患者掌握好手术时机,根据病情选择治疗方式,重视围手术期支持治疗以及适时手术治疗,是降低死亡率,提高疗效的重要措施。

    Release date:2016-09-08 11:54 Export PDF Favorites Scan
  • Risk factors for sleep disorders in ICU patients: a meta-analysis

    ObjectiveTo systematically review the risk factors associated with sleep disorders in ICU patients.MethodsWe searched The Cochrane Library, PubMed, EMbase, Web of Science, CNKI, Wanfang Data, VIP and CBM databases to collect cohort studies, case-control studies and cross-sectional studies on the risk factors associated with sleep disorders in ICU patients from inception to October, 2018. Two reviewers independently screened literature, extracted data and evaluated the bias risk of included studies. Then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 9 articles were included, with a total of 1 068 patients, including 12 risk factors. The results of meta-analysis showed that the combined effect of equipment noise (OR=0.42, 95%CI 0.26 to 0.68, P=0.000 4), patients’ talk (OR=0.53, 95%CI 0.42 to 0.66, P<0.000 01), patients’ noise (OR=0.39, 95%CI 0.21 to 0.74, P=0.004), light (OR=0.29, 95%CI 0.18 to 0.45, P<0.000 01), night treatment (OR=0.36, 95%CI 0.26 to 0.50, P<0.000 01), diseases and drug effects (OR=0.17,95%CI 0.08 to 0.36, P<0.000 01), pain (OR=0.37, 95%CI 0.17 to 0.82, P=0.01), comfort changes (OR=0.34,95%CI 0.17 to 0.67,P=0.002), anxiety (OR=0.31,95%CI 0.12 to 0.78, P=0.01), visit time (OR=0.72, 95%CI 0.53 to 0.98, P=0.04), economic burden (OR=0.63, 95%CI 0.48 to 0.82, P=0.000 5) were statistically significant risk factors for sleep disorders in ICU patients.ConclusionCurrent evidence shows that the risk factors for sleep disorders in ICU patients are environmental factors (talking voices of nurses, patient noise, and light), treatment factors (night treatment), disease factors (disease itself and drug effects, pain,) and psychological factors (visiting time, economic burden). Due to the limited quality and quantity of included studies, more high quality studies are needed to verify the above conclusions.

    Release date:2019-07-18 10:28 Export PDF Favorites Scan
  • Clinical Analysis of 34 Patients with Severe H1N1 Influenza

    Objective To analyze the clinical features and treatment of severe H1N1 influenza.Methods The clinical data of 34 patients with severe H1N1 influenza admitted to intensive care unit from October to December 2009 were reviewed. Results The patients aged 3 months to 60 years with an average of ( 13. 9 ±4. 5) years, of which 24 patients were younger than 7 years old. Fever( 30 cases) , cough( 32 cases) , progressive shortness of breath( 19 cases) were the main symptoms. White blood cell count was normal in 21 cases, increased in 6 cases, and decreased in 7 cases. Lymphocyte count was normal in 16 cases, increased in 12 cases, and decreased in6 cases. Chest X-ray films showed bilateral or unilateral patchy pulmonary fuzzy shadows in28 cases. Chest CT showed diffuse interstitial lesion in1 case, pleural effusion in 2 cases, and bronchiectasis in 1 case. The hepatic and myocardial enzymogramparameters were all abnormal.30 cases were treated by oseltamivir and ribavirin, 4 cases by methyllprednisolone, and 6 cases by gamma globulin. 8 cases underwent routine intubation and mechanical ventilation, and 5 cases received non-invasive mechanical ventilation. All 34 patients were cured. Conclusions Lung, heart, and liver are the major target organs in severe H1N1 influenza. Mechanical ventilatory support is an important treatment for severe H1N1influenza.

    Release date:2016-08-30 11:53 Export PDF Favorites Scan
  • Experimental Study of Relationship of Zonula Occludens-1 and Microvascular Injury in Rats with Severe Acute Pancreatitis

    Objective To investigate the changes of expression of zonula occludens-1(ZO-1) in rats with severe acute pancreatitis (SAP), and to study the relationship between the ZO-1 protein and microvascular injury in rats with SAP. Methods Forty-eight Wistar rats were randomly divided into sham-operation (SO) group and SAP group, each group enrolled 24 rats. Pancreas of rats in SO group were flipped only after laparotomies, but rats of SAP group were injected with 5% sodium taurocholate by retrograding cholangiopancreatography micro pump to produce the SAP model. At 6, 12, and 24 hours after operation, 8 rats were sacrificed to get abdominal aortic blood for testing the levels of peripheral blood amylase, trypsin, interleukin-8(IL-8), tumor necrosis factor-α(TNF-α), and ZO-1 protein. At the same time, pancreatic tissues were got to perform HE staining and immunohistochemical staining for observation of the pathological changes and the expression of ZO-1 protein respectively. Results Compared with SO group at the same time, the levels of peripheral blood amylase, trypsin, IL-8, TNF-α, and ZO-1 protein were all higher in SAP group (P < 0.05). The level of amylase in SAP-24 hours group was higher than those of 6 hours group and 12 hours group(P < 0.05), the levels of trypsin, IL-8, and ZO-1 protein in SAP group increased over time (P < 0.05), but levels of TNF-αin 3 time points of SAP group did not differ with each other significantly(P > 0.05). Results of regression showed that in the SAP group, the level of ZO-1 protein in serum was significantly positive correlated with pathological score of pancreatic tissue(b=0.96, P < 0.05), levels of serum amylase(b=0.87, P < 0.05), trypsin(b=0.72, P < 0.05), and serum IL-8 (b=0.69, P < 0.05), but was not significantly correlated with level of TNF-α(P > 0.05). HE staining results showed that damage of pancreatic tissues became worse over time in SAP group, and the pathological score of SAP-6 hours group was lower than those of 12 hours group and 24 hours group (P < 0.05). Immunohistochemical staining results showed that, in SAP group, with the extension of time, the number of ZO-1 protein granules in pancreatic acinar cells and capillary wall reduced, and expressed in capillaries discontinuously. Conclusion During the course of SAP, the concentration of serum ZO-1 protein increase, but its expression in the pancreatic tissue degrade, which is closely associated with microvascular injury and progression of pancreatic tissues.

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  • Percutaneous Cholecystostomy Guided by Ultrasound for Acute Cholecystitis in High-Risk Patients

    目的 评价B超引导下经皮经肝胆囊穿刺引流术(PC)治疗老年急性重症胆囊炎的效果。方法 18例重症胆囊炎的老年患者接受了在局部麻醉下经皮经肝穿刺胆囊置管引流。结果 所有患者穿刺置管成功,无一例发生并发症,且症状及体征均于术后24~48 h明显改善。结论 PC是一种微创、有效、廉价、可靠的治疗老年急性重症胆囊炎的方法。

    Release date:2016-08-28 04:47 Export PDF Favorites Scan
  • 血清胆碱酯酶水平对危重症病情判断的意义

    目的 了解危重症患者血清胆碱酯酶( CHE) 的变化情况, 探讨血清CHE 水平下降的原因及对病情严重程度和预后判断的作用。方法 观察2007 年5 月至2008 年3 月入北京协和医学院整形外科医院ICU 病房的42 例危重症患者。用APACHEⅡ评分系统评价病情的危重程度, 分析血清CHE 浓度变化与APACHEⅡ评分的相关性, 同时观察患者肝功能的变化情况。结果 患者血清CHE 浓度较发病前降低[ ( 187. 83 ±78. 18) U/L 比( 270. 43 ±91. 66) U/L, P lt;0. 01] , 其中23 例低于正常参考值。死亡患者CHE 浓度显著低于存活患者[ ( 140.26 ±54. 81) U/L 比( 208. 84 ±69. 96) U/L, P lt;0. 01] 。血清CHE 水平与APACHEⅡ评分呈显著负相关( r = - 0. 43, P lt; 0. 01) 。血清总胆汁酸( TBA) 发病前后无显著差异。死亡组与存活组丙氨酸转氨酶与门冬氨酸转氨酶无显著差异。结论 ICU 中危重症患者血清CHE 浓度下降明显, APACHEⅡ评分越高, CHE 下降程度越大。患者CHE 下降不是由肝实质损害引起。测定血清CHE 可作为判断ICU 危重症患者病情和预后的一个有意义的指标。

    Release date:2016-09-14 11:25 Export PDF Favorites Scan
  • Effects of Early Hemofiltration on TNF-α and IL-1β in Pigs with Severe Acute Pancreatitis

    【Abstract】Objective To study the influence of early hemofiltration on plasma concentrations of proinflammatory cytokines TNF-α and IL-1β and their transcription levels in severe acute pancreatitis (SAP) pigs. Methods The model of SAP was induced by retrograde injection of artificial bile into pancreatic duct in pigs. Animals were divided randomly into two groups: SAP hemofiltration treatment group (HF group, n=8) and SAP no hemofiltration treatment group (NHF group, n=8). TNF-α and IL-1β plasma concentrations were measured by ELISA. Their transcription levels in the tissues of pancreas, liver and lung were assayed by semi-quantitative reverse transcription polymerase chain reaction. Results After hemofiltration treatment, the plasma concentrations of TNF-α and IL-1β increased gradually but were lower than those of NHF group at the same time spot 〔at 6 h after hemofiltration treatment, (618±276) pg/ml vs (1 375±334) pg/ml and (445±141) pg/ml vs (965±265) pg/ml, P<0.01〕. At 6 h after hemofiltration treatment, the transcription levels of TNF-α and IL-1β in tissues of pancreas, liver and lung were lower than in NHF group (57.8±8.9 vs 85.7±17.4, 48.0±8.1 vs 78.1±10.2, 46.2±9.6 vs 82.4±10.5; 55.9±9.0 vs 82.2±15.7, 40.6±9.2 vs 60.0±10.6, 35.7±9.8 vs 58.1±9.3, P<0.01). Conclusion Early hemofiltration can reduce TNF-α and IL-1β plasma concentrations and transcription levels in SAP pigs.

    Release date:2016-08-28 04:44 Export PDF Favorites Scan
  • 胸腺瘤合并重症肌无力患者的手术及围术期处理

    目的 为提高胸腺瘤合并重症肌无力(MG)患者手术的安全性和治愈率,总结其临床经验。方法 1991年7月至2005年8月收治胸腺瘤合并MG23例,术前均给予肾上腺糖皮质激素和抗胆碱酯酶药物治疗,病情稳定后行胸腺扩大切除术,对发生MG危象患者予以气管切开或气管内插管,必要时使用呼吸机辅助呼吸。结果 全组无手术死亡,术后2例发生MG危象,经处理后痊愈。随访20例,失访3例,随访时间3个月~10年,缓解3例,明显改善11例,改善5例,无变化1例。其中1例胸腺瘤部分切除患者术后4个月死于肿瘤复发。结论 胸腺瘤合并MG患者除临床证实肿瘤无法切除或已胸外转移者外,其余均应手术治疗,完全切除胸腺瘤并清除前纵隔脂肪组织;正确的围术期处理是降低手术并发症及死亡率的关键。

    Release date:2016-08-30 06:23 Export PDF Favorites Scan
  • 106例重症急性胰腺炎临床治疗分析

    Release date:2016-08-29 09:20 Export PDF Favorites Scan
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