【Abstract】ObjectiveTo review the epidemiology, etiology, pathology, clinical presentation, diagnosis and treatment, recurrance and prognosis of Mondor disease. MethodsLiteratures on Mondor disease were reviewed, and our study of Mondor disease was also included. ResultsMondor disease is difficult to diagnose, but is with good prognosis in most patients. It’s unclear whether Mondor disease is associated with the etiology of breast cancer. ConclusionThe diagnosis and therapy of Mondor disease are important, especially when it is accompanied with breast cancer.
ObjectiveTo systematically review the effect of pre-treating the catheters with dexamethasone for preventing PICC-associated phlebitis. MethodsWe electronically searched PubMed, EMbase, The Cochrane Library (Issue 4, 2012), CNKI, CBM, WanFang Data and CQVIP for studies about pre-treating the catheters with dexamethasone to prevent PICC-associated phlebitis from inception to March 2013. Relevant studies including grey literature were also manually searched. Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data and evaluated the methodological quality of the included studies. Then meta-analysis was performed using the software RevMan 5.0. ResultsA total of 13 studies involving 1 965 cases (1 025 cases in the dexamethasone group, and 940 cases in the control group) were included. The results of meta-analysis showed that pre-treating the catheters with dexamethasone could significantly decrease the incidence of PICC-associated phlebitis (RR=0.29, 95%CI=0.22 to 0.39, P < 0.000 1). However, no significant difference was found for the PICC-associated other complications, such as pipe blockage, bleeding, swelling of puncture site, allergy and atopic catheter. ConclusionPre-treating the catheters with dexamethasone soltion before inserting could reduce the incidence of PICC-associated phlebitis. The aforementioned conclusion needs to be further validated by more high-quality and large-scale randomized controlled trials.
PURPOSE:To investigate the content of vascular endothelial growth factor (VEGF)in vitreous of patients with retinal vascula'r proliferative diseases. METHODS:The concentration of VEGF in undiluted vitreous samples from patients with retina vein occlusion (RVO) (n=7),Eales disease (n=7)and controls (n=7) was measured by enzyme linked immunosorbent assay (EL1SA). RESULTS:The levels of vitreous VEGF were significantly higher 13 folds in patients with RVO(4.67plusmn;3.38)ng/ml and 5 folds in patients with Eales disease(1.79plusmn;0.44)ng/ml than in controls (0.35plusmn;0.15)ng/ml separately(P＜0. 01). CONCLUSIONS:VEGF might play a part in mediating the neovascularization of retinal vascular diseases. （Chin J Ocul Fundus Dis,1997,13:171-173）
Objective To assess the efficacy and safety of Hirudoid for microcirculation disorder. Methods We searched The Cochrane Library (Issue 4, 2009), PubMed, EMbase, CNKI, CBM, and VIP databases up to December 2009. Randomized controlled trials (RCTs) or quasi-RCTs concerning Hirudoid for microcirculation disorder were included. The methodological quality of the included studies was assessed according to the Cochrane Reviewer’s Handbook 5.0.1, and meta-analyses were conducted using RevMan software 5.0. Results Twenty-five RCTs were included, of which only one was graded as high quality and others were of low quality. The results of meta-analyses showed: Hirudoid could be effective in preventing the occurrence of phlebitis (OR=0.18, 95%CI 0.13 to 0.25). Hirudoid for treating phlebitis was also significantly better than magnesium sulfate or placebo (OR=7.18, 95%CI 4.59 to 11.22) and the time to symptom relief of Hirudoid was significantly shorter than placebo (MD= – 29, 95%CI – 37.30 to – 20.70). Hirudoid for internal fistula in hemodialysis patients was better than the simple hot compress (OR=8.89, 95%CI 4.25 to 18.58), and also better than the magnesium sulfate plus hot compress (OR=7.62, 95%CI 2.84 to 20.44). Hirudoid could also prevent the formation of hematoma and eliminate hematoma quickly. Hirudoid for tissue injury caused by irritating fluid extravasation was significantly better than magnesium sulfate (OR=4.25, 95%CI 2.06 to 8.78). Conclusion Hirudoid can significantly improve the microcirculation disorder, especially to the phlebitis. Due to the low quality of the included studies, further, more high quality trials are required.
ObjectiveTo investigate the effect of 5% dextrose intravenous infusion for phlebitis caused by amiodarone. MethodsA total of 136 patients treated in our hospital between June 2011 and March 2012 were randomly assigned into control group with 63 patients and intervention group with 73 patients. The control group was administrated 600 mg amiodarone with 15 drops/minute intravenous injection once daily, for 3 days, while for the intervention group patients, we added 5% dextrose solution infusion in the same channel at the same time. ResultsPhlebitis occurred in 22 patients (34.9%) in the control group, while the intervention group had only 11 (15.0%) (χ2=7.252,P=0.007). ConclusionInfusion of 5% dextrose solution can significantly reduce the occurrence of phlebitis caused by amiodarone.
目的:观察艾灸联合芦荟、红花、当归酒精提取液治疗输液并发静脉炎的临床疗效。方法:将60例静脉炎患者随机分为两组,观察组采用艾灸联合芦荟、红花、当归酒精提取液治疗,对照组采用50%硫酸镁治疗,并进行疗效对比。结果: 观察组痊愈22例、显效6例、有效2例、无效0例,有效率100%;对照组痊愈13例、显效8例、有效3例、无效6例,有效率80%;两组相比差异有统计学意义(Plt;0005)。结论:艾灸联合芦荟、红花、当归酒精提取液具有活血化瘀、散结止痛、抗炎解毒、促进损伤组织细胞修复作用。