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find Keyword "靶点" 22 results
  • Target and mechanism of traditional Chinese medicine in acute pancreatitis

    Acute pancreatitis (AP) is a common clinical emergency of the abdomen with increasing incidence and lack of effective treatment. Traditional Chinese medicine, as a treasure of the Chinese people, has been used in the treatment of AP for decades with favorable therapeutic effects. Currently, clinical trials and experimental studies have shown that traditional Chinese medicine has the effects of inhibiting pancreatic enzyme activity, anti-inflammation, promoting gastrointestinal dynamics, as well as delaying the progress of AP, improving clinical symptoms, reducing related complications, and reducing the mortality rate. Therefore, traditional Chinese medicine has considerable clinic value in treating AP. Based on the related research progress and clinical practice of our team, the authors summarized the targets and mechanism of traditional Chinese medicine in treating AP.

    Release date:2024-03-23 11:23 Export PDF Favorites Scan
  • Research progress of circRNAs in thyroid papillary carcinoma

    ObjectiveTo summarize the role of circular RNA (circRNAs) in thyroid papillary carcinoma (PTC) and the emphasis of future research.MethodRelevant literatures in recent years about the biological function of circRNA and its role in PTC were reviewed.ResultscircRNAs had abnormal expression in PTC tissues. Besides, by working as miRNA sponges or interacting with RNA-binding proteins, circRNAs regulated the expression of proteins that were associated with cell proliferation, apoptosis, invasion, and metastasis, which could affect the biological characteristics of tumor cells.ConclusioncircRNAs are expected to be the biomarkers for early diagnosis of PTC or potential targets for PTC therapy and provid therapeutic bases to prevent PTC.

    Release date:2020-07-26 02:35 Export PDF Favorites Scan
  • A comparative cross-sectional study of Chinese and American lung caner drug trial in 2019

    ObjectiveTo compare the current status of clinical studies regarding lung cancer between China and the United States in 2019, and to indicate the weakness, trend and future development direction of clinical studies drug treatment in China.MethodsThe data of lung cancer clinical studies from January 1st to November 30th, 2019 in China and the United States were retrieved and analyzed through Informa pharmaprojects database.ResultsThe United States was superior on the number of projects (128 vs. 156) and research institutions (743 vs. 2 250). Compared with the United State, there were more phase Ⅲ confirmatory researches (19.5% vs. 10.3%), bioequivalent drug researches (3.1% vs. 0%), and researches initiated by academic institutions (39.8% vs. 28.1%) in China. The United States exhibited advantages in phaseⅠ andⅠ/Ⅱstudies (25.8% vs. 60.3%), immunodrugs (49.2% vs. 60.3%), primary tested drug ratio (61.7% vs. 93.6%), targets abundance (32.9% vs. 69.6%), and chimeric antigen receptor-T (CAR-T, 0.7% vs. 7.1%).ConclusionCompared with the United States, China should pay more attention to innovative drug investigations in early phase of clinical studies, especially novel immune agents, vaccines, and CAR-T.

    Release date:2020-03-25 09:52 Export PDF Favorites Scan
  • Nuclear Factor Kappa B and Liver Injury

    Objective To summarize the role of nuclear factor kappa B (NF-κB) in the occurrence and progression of various sorts of liver injury. Methods Literatures on the structures, property of molecular biology and function of NF-κB, as well as its relationships with liver injury were collected and reviewed. Results NF-κB was an important nuclear factor existed in cells widely distributed in most cell types. The activation of NF-κB was induced by various sorts of liver injury. The activated NF-κB could affect the liver injury by regulating cytokines, adhesion molecules, and activating factor involving in immunologic reaction, inflammatory reaction and the apoptosis. Conclusion  NF-κB plays an important role during the occurrence and progression of liver injury, and may become a new target in the treatment of liver injury.

    Release date:2016-08-28 04:08 Export PDF Favorites Scan
  • 微小 RNA 和伴海马硬化的内侧颞叶癫痫:人类海马全微小 RNA 组谱

    内侧颞叶癫痫(mesial temporal lobe epilepsy, mTLE)是一种严重的以反复癫痫发作为特征的神经系统疾病。mTLE 通常伴有海马神经元变性导致的海马硬化(Hippocampal sclerosis,HS), 它是与 mTLE 患者耐药性相关的最常见的形态学改变。对 mTLE+HS 的认识不足使其治疗复杂化。mTLE+HS 的潜在病理机制可能涉及异常的基因表达调控,包括涉及微小 RNA(microRNA, miRNA)的转录后网络。 miRNA 表达调控在包括癫痫的多种疾病中都有报道。但是,mTLE+HS 的 miRNA 谱暂未被完全了解,需要进一步解决。在此,为了揭示 miRNA 的异常表达,我们关注了 33 例 mTLE+HS 患者和 9 具对照者尸检的海马 miRNA 分析。研究中,通过联合两种不同的 miRNA 分析方法,以及下一代测序技术和 miRNA 特异性实时定量聚合酶链式反应,我们显著降低了技术相关的偏移(最常见的是 miRNA 分析数据的假阳性)。这些方法结合起来明确并验证了 20 例癫痫患者海马中 miRNA 的表达改变。在 mTLE+HS 患者中,有 19 例 miRNA 上调,1 例下调。其中 9 种 miRNA 以往没有报道与癫痫有联系,19 例异常表达的 miRNA 可能调节与癫痫相关的靶点和通路(例如:钾离子通道,γ-氨基丁酸,神经营养因子信号传导和轴突导向)。研究通过明确 miRNA 在 mTLE+HS 中表达,扩展了当前对 mTLE+HS 中 miRNA 介导的基因表达调控的认知,包括 9 个新发现的 miRNA 异常表达及其可能的靶点。 这些发现进一步提升了基于 microRNA 的生物标志物或疗法的可能性。

    Release date:2018-03-20 04:09 Export PDF Favorites Scan
  • The role of retinal signaling molecules in the occurrence and progression of myopia

    With the surged prevalence of myopia, the pathogenic mechanism underlying myopia has attracted attention. At present, it is generally believed in the flied that the reduced blood perfusion in the choroid is crucial for myopigenesis. Then, in the process of myopigenesis, how are the blurred visual signals transmitted to the choroidal blood vessels through the retina and retinal pigment epithelium, leading to the reduced choroidal blood perfusion. The cellular and molecular mechanisms underpinning this process remain elusive. In recent years, the theory of scleral hypoxia has attracted much attention. Popular signaling molecules in current research include dopamine, epidermal growth factor, retinoic acid, cholinergic molecules and adenosine, etc. These factors are likely to participate in signal transduction in retina and RPE, thus causing changes in choroidal blood flow and affecting the occurrence and development of myopia. Therefore, these signaling factors and their downstream pathways may provide new ideas for the prevention and control of myopia targets.

    Release date:2023-09-12 09:11 Export PDF Favorites Scan
  • Research progress of effect of gut microbiota on non-small cell lung cancer

    The human gut microbiota regulates many host pathophysiological processes including metabolic, inflammatory, immune and cellular responses. In recent years, the incidence and mortality of lung cancer have increased rapidly, which is one of the biggest challenges in the field of cancer treatment today, especially in non-small cell lung cancer. Animal models and clinical studies have found that the gut microbiota of non-small cell lung cancer patients is significantly changed compared with the healthy people. The gut microbiota and metabolites can not only play a pro-cancer or tumor suppressor role by regulating immune, inflammatory responses and so on, but also be related with radiotherapy and chemotherapy of non-small cell lung cancer and the resistance of immunotherapy. Therefore, gut microbiota and related metabolites can be both potential markers for early diagnosis and prognosis in patients with non-small cell lung cancer and novel therapeutic targets for targeted drugs. This study will review the latest research progress of effect of gut microbiota on non-small cell lung cancer, and provide a new diagnosis and treatment ideas for non-small cell lung cancer.

    Release date:2023-05-09 03:11 Export PDF Favorites Scan
  • Research progress of molecular targeted therapy for pancreatic cancer

    Objective To summarize the progress in related basic research of molecular targeted therapy in pancreatic cancer. Method The relevant literatures on oncogenes, epigenome, tumour microenvironment and immunotherapy in recent years at home and abroad were reviewed. ResultsIn basic research, molecularly targeted drugs had shown some efficacy in the treatment of progression of pancreatic cancer, however, in clinical trials, more satisfactory results were not achieved. Conclusion Molecularly targeted therapies for pancreatic cancer are still at a preliminary stage of exploration, and basic research has not yet been effectively translated clinically, which requires further exploration efforts in subsequent studies to provide a more solid and reliable basis for precise treatment of pancreatic cancer and achieve better clinical benefits.

    Release date:2022-12-22 09:56 Export PDF Favorites Scan
  • 深部脑刺激治疗药物难治性癫痫的研究现状

    癫痫是一种短暂性脑神经异常放电引起人体机能出现异常的一种疾病,该疾病目前已然波及全球5 000万余人,人们通常使用药物控制发作,尽管引入了各种新型抗癫痫发作药物(Anti-seizure medications,ASMs),仍有约1/3的患者无法通过ASMs正规治疗得到有效控制,进而发展为药物难治性癫痫(Drug-resistant epilepsy,DRE),持续的癫痫发作会对患者的身体、心理、家庭以及社会造成严重的负担。随着神经外科对立体定向技术的逐步深入研究,研究发现深部脑刺激(Deep brain stimulation,DBS)是一种广泛应用于精神和神经疾病的有效治疗手段,目前,DBS在治疗帕金森病(Parkinson’s disease,PD)方面已取得良好成效,同时该技术的可调节性、可逆性及良好的安全性促使人们通过DBS对精神神经系统疾病进行更深入的研究。目前世界各地已有一定数量的患有不同精神障碍或神经障碍的患者接受DBS治疗,其运用于DRE也得到了良好疗效,本文就DBS的神经调控机制、相关靶点、副作用及研究现状作如下概述,以期对DRE的治疗提供治疗新思路。

    Release date:2023-03-13 02:15 Export PDF Favorites Scan
  • Research progress of targeted therapy for radioactive iodine-refractory differentiated thyroid cancer

    Objective To summarize the advance in targeted therapy for radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC). Method The literatures relevant to the targeted therapy for RAIR-DTC were reviewed and summarized. Results Targeted therapy for RAIR-DTC mainly included multi-kinase inhibitors suppressing angiogenesis and mutation-specific kinase inhibitors targeting specific mutations. Representative multi-kinase inhibitors such as sorafenib and lenvatinib, which significantly prolonged progression-free survival, had been approved to put into clinical use, though there were shortcomings such as adverse effects and resistance. Mutation-specific kinase inhibitors acted on targets such as RET, mitogen-activated protein kinase pathway, phosphoinositide 3-kinase pathway respectively, with relatively small side effects, most of which had only been applied in clinical trials up to now. Conclusions Targeted therapy for RAIR-DTC has made rapid progress in recent years, filling the gap in treatment for RAIR-DTC. Further explorations and investigations are needed to establish a more effect and safer treatment mode.

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