目的 研究盐酸氨基葡萄糖联合抗骨增生片治疗膝骨关节炎（KOA）的可行性及安全性。 方法 2011年1月－2012年8月选取90例KOA患者，按关节面改变部位归入A组（髌股关节面改变）、B组（胫股关节面改变）、C组（全关节软骨改变），每组30例。均予以盐酸氨基葡萄糖、抗骨增生片治疗，12周后观察治疗前后临床疗效、综合疗效及安全性等指标及评分。 结果 ① 3组比较，A组疗效高于B、C组（P＜0.05）；② A组与B、C两组在平地行走20 m疼痛评分、关节压痛度评分和骨关节炎指数（WOMAC）评分方面差异有统计学意义（P＜0.05）；③ A组和B、C两组在患者自我疗效评价、医生疗效评价方面差异有统计学意义（P＜0.05）；④ A组在治疗12周后血液血沉、C反应蛋白（CRP）、白细胞介素（IL）-1、IL-6、肿瘤坏死因子-α（TNF-α）较治疗前差异有统计表学意义（P＜0.05）；B组则在CRP、IL-6、TNF-α较治疗前有差异（P＜0.05）；C组仅在CRP、TNF-α较前有差异（P＜0.05）；⑤3组不良反应发生率则无明显差异（P＞0.05）。 结论 盐酸氨基葡萄糖联合抗骨增生片治疗髌股关节面改变的KOA疗效优于胫股关节改变，且治疗方案可行、安全、优效。
目的 探讨关节镜清理术配合盐酸氨基葡萄糖对膝骨关节炎的治疗作用。 方法 2009年6月－2011年6月纳入轻度膝骨关节炎（AhlbackⅠ级）患者135例，随机分成3组。A组（n=45）接受关节镜清理术治疗；B组（n=45）口服盐酸氨基葡萄糖胶囊治疗；C组（（n=45）先行关节镜清理术治疗，术后口服盐酸氨基葡萄糖胶囊。观察3组Lequesne评分和WOMAC指数，用以评价治疗效果。 结果 成功随访患者123例，随访时间8个月。治疗后各组Lequesne评分和WOMAC指数较治疗前均显著好转（P＜0.01），其中治疗后C组好转较A组和B组具有显著性（P＜0.01），但B组和C组之间差异无统计学意义（P＞0.05）。 结论 关节镜清理术配合盐酸氨基葡萄糖，较之单用关节镜清理术或盐酸氨基葡萄糖，对膝骨关节炎的治疗有更好的效果。
ObjectiveTo evaluate the efficacy and safety of glucosamine hydrochloride in the treatment of osteoarthritis. MethodsA total of 150 patients with osteoarthritis treated between April 2014 and April 2015 were randomly divided into control group and trial group with 75 in each. Patients in the trial group accepted oral glucosamine hydrochloride, while those in the control group were given diclofenac sodium. Lequesne index, total effective rate and the incidence of adverse reactions of both groups were calculated before and 2, 4, 6 and 8 weeks after treatment, and 2 weeks after drug withdrawal. ResultsIn both groups, Lequesne index started to decrease after 2 weeks of treatment (P<0.05), and reached the minimum value at treatment week eight (P<0.05). The Lequesne index 2 weeks after drug withdrawal was still obviously lower than that before treatment (P<0.05). There was no significant differences in the total effective rate at treatment week eight (83.1% for the control group and 80.9% for the trial group) or the total effective rate 2 weeks after drug withdrawal (80.0% for the control group and 79.4% for the trial group) between the control group and the trial group (P>0.05). The incidence of adverse reactions of the trial group (6.7%) was significantly lower than that of the control group (21.3%) (P<0.05). ConclusionGlucosamine hydrochloride is effective and safe in the treatment of osteoarthritis, which is suitable for long-term treatment.
ObjectiveTo compare the clinical efficacy of glucosamine hydrochloride and diacerein for patients with knee osteoarthritis and the MRI variation. MethodsBetween January and June 2014, 90 patients with knee osteoarthritis were randomized into three groups: group A (treated by glucosamine hydrochloride), group B (treated by diacerein) and group C (treated by both glucosamine hydrochloride and diacerein). The score of Western Ontario and McMaster Universities (WOMAC) index of osteoarthritis, MRI cartilage injury Recht grading and the curative effects for bone marrow edema, joint cavity effusion and meniscus injury were compared before and after the treatment. ResultsThe scores of WOMAC after treatment in all the groups were improved, while the therapeutic effect of group C lasted longer when medical treatment suspended. The number of articular surface with different degrees of cartilage injury showed no statistically significant change in all three groups (P ＞ 0.05) . The state of bone marrow edema and joint cavity effusion were improved with a statistically significant difference in all groups (P ＜ 0.05) . Patients with lateral meniscus degeneration in group A and patients with medial meniscal tear in group B both increased with statistically significant differences (P ＜ 0.05) . However, in group C, patients with lateral meniscus degeneration or meniscal tear decreased with statistically significant differences (P ＜ 0.05) . ConclusionsThe treatment for osteoarthritis by glucosamine hydrochloride is effective, and the curative effect lasts longer when treated by both glucosamine hydrochloride and diacerein. Glucosamine hydrochloride ameliorates the bone marrow edema and joint cavity effusion. Treatment together with diacerein leads to a better therapeutic effect for patients with meniscus degeneration, yet further studies are needed to prove its effects in ameliorating cartilage injury.
ObjectiveTo observe the clinical effect of combined traditional Chinese and Western medicine in the treatment of knee osteoarthritis (KOA). MethodsA total of 180 KOA patients treated between January 2012 and June 2015 were randomly assigned to 3 groups: Chinese medicine group (group A, n=60) with acupuncture and irradiation therapy of specific electromagnetic wave therapeutic apparatus , western medicine group (group B, n=60) with oral glucosamine hydrochloride tablets and knee joint cavity injection of sodium hyaluronate, and integrated traditional Chinese and Western medicine group (group C, n=60) with treatments combining those in both group A and B. The treatment course was 6 weeks. The Western Ontario & McMaster University (WOMAC) osteoarthritis index score and total effective rate were evaluated before treatment and 2 weeks after treatment, end of treatment and 5 months after treatment. ResultsAfter treatment, the average improvement of WOMAC scores in the three groups was significantly different (P ＜ 0.05) . The total effective rate was 78.33% in group A, 83.33% in group B, and 91.67% in group C. The difference of total effective rate between group C and A, and between group C and B was statistically significant (P＜0.05) ; and it was also statistically significant between group A and B (P ＜ 0.05) . There were two cases of adverse reactions in group A, two in group B, and two in group C, and the reactions were all relatively mild without any serious adverse events. ConclusionsChinese medicine and western medicine are both effective and safe for the treatment of KOA. When they are combined, the effect is further enhanced with no increase of adverse reactions.
目的 探讨关节镜手术联合口服盐酸氨基葡萄糖治疗膝骨关节炎（KOA）的近期临床疗效。 方法 选取2011年1月－12月具有关节镜手术指征的KOA患者86例，按手术顺序单双号分成两组，试验组（单号）行关节镜手术联合口服盐酸氨基葡萄糖治疗，对照组（双号）行关节镜手术治疗。采用Lequesne指数对两组患膝术前，术后第4、6周进行评分及疗效分析。 结果 两组患膝术前与术后第4、6周Lequesne指数得分比较，差异有统计学意义（P＜0.05）；两组术后近期疗效比较，差异有统计学意义（P＜0.05）。 结论 关节镜手术联合口服盐酸氨基葡萄糖治疗KOA具有良好的近期疗效，优于单用关节镜手术治疗者。
ObjectiveTo observe the effectiveness of oral glucosamine hydrochloride and cupping therapy in the treatment of knee osteoarthritis. MethodsA total of 113 patients treated from February 2013 to February 2015 were randomly divided into three groups. All the three groups of patients underwent conventional treatment. The Cupping treatment group had 39 patients; 37 patients were treated with oral glucosamine hydrochloride, and another 37 patients accepted combined treatments of cupping therapy with oral glucosamine hydrochloride. Six weeks after treatment, pain degree of the patients and Lequesne index were used to assess the clinical efficacy of the treatments. Patients who had oral glucosamine hydrochloride underwent routine examinations of blood and urine, and received liver and kidney examinations. One year later, telephone follow-up was conducted to observe long-term efficacy. ResultsSix weeks after treatment, the combined treatment group was significantly better than the other two groups in terms of pain relief degree and effective rate (P ＜ 0.05) . One year after treatment, the combined treatment group and the oral treatmentgroup had a significant advantage over the cupping treatment group (P ＜ 0.05) , while there was no significant difference between the combined treatment group and oral treatment group. ConclusionsThe combined oral glucosamine hydrochloride and cupping therapy has an obvious short-term efficacy, which quickly relieves pain and improves the activity function of the knee. Oral glucosamine hydrochloride has a very good effect in the long-term treatment of osteoarthritis.
ObjectiveTo discuss the efficacy and safety of the joint application of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection in the treatment of knee osteoarthritis. MethodsFrom January 2014 to January 2015, 72 patients who matched the criteria of moderate knee osteoarthritis were randomly divided into two groups according to the table of random number: oral glucosamine hydrochloride tablet and knee joint cavity ozone injection group (group G+O) and ozone group (group O). Patients of group G+O orally took glucosamine hydrochloride tablets (0.48 g, 3 times/day) for twelve weeks, and ozone was injected into the patients’ knee joint once a week for the first four weeks. The treatment for group O patients was the same with Group G+O, except that the glucosamine hydrochloride tablets were replaced by glucosamine hydrochloride placebo (2 tablets, 3 times/day, taking orally). We recorded the Visual Analogue Scale (VAS) score, Western Ontario & McMaster University (WOMAC) osteoarthritis index score and the adverse reactions before treatment and in the first, third and sixth month after treatment. ResultsPatients’ VAS scores and WOMAC scores of both the two groups in the first, third and sixth month after treatment were significantly different from those before the treatment (P ＜ 0.05) . In the first month after treatment, there were no significant difference in patients’ VAS scores and WOMAC scores between the two groups (P ＞ 0.05) . In the third and sixth month after treatment, there were significant differences in patients’ VAS scores and WOMAC scores between the two groups (P ＜ 0.05) . There was no obvious adverse reactions during the treatment. ConclusionsThe combined application of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection and the ozone treatment for moderate knee osteoarthritis are both effective, without any adverse reaction. The combined treatment of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection on moderate knee osteoarthritis has better long-term efficacy, and it is worth spreading.
目的 观察盐酸氨基葡萄糖治疗膝骨关节炎（KOA）的临床疗效。 方法 2010年5月－2012年7月将130例经膝关节镜清理术后的KOA患者随机分成A、B两组，每组65例。A组联合口服盐酸氨基葡萄糖胶囊750 mg，2次/d，6周为1个疗程，治疗3个疗程；B组联合口服尼美舒利胶囊0.1 g，2次/d，服用12周。采用Lequesne指数作为疗效评定指标，观察治疗前后膝关节体征及症状变化，休息痛、运动痛、压痛、肿胀、晨僵和行走能力的改善情况。 结果 B组患者在治疗早期症状改善优于同期A组，且在第3个月有统计学意义（P＜0.05），随着治疗时间的延长，A组患者总有效率在1、3、6个月分别为70.8%、76.9%和92.3%，均呈逐渐上升趋势，且第6个月疗效较前2个时间点差异有统计学意义（P＜0.05）。分别停药后继续随访至1年，两组患者总有效率均有所下降，但A组疗效仍优于B组，且有统计学意义（P＜0.05）。A组出现不良反应2例，B组4例，均较轻微，无严重不良事件发生。 结论 盐酸氨基葡萄糖在改善OA患者膝关节症状等方面效果肯定，且疗效较稳定，安全性良好；但远期疗效仍需随访观察。
目的 观察评价盐酸氨基葡萄糖结合塞来昔布治疗膝骨关节炎（KOA）的疗效及安全性。 方法 2001年3月－2012年3月采用随机对照方法，将184例KOA患者随机分为对照组与试验组，各92例。对照组单独给予塞来昔布，试验组给予塞来昔布和盐酸氨基葡萄糖，共治疗8周，停药后继续观察4周。采用Lequesne指数作为疗效评分标准，观察服药前后的膝关节症状变化，包括休息痛、运动痛、压痛、肿胀、晨僵和行走能力的改善程度，纪录不良反应及实验室生化指标等。 结果 两组Lequesne指数在治疗前相比均明显下降，两组治疗8周后Lequesne总指数比较差异均有统计学意义（P＜0.05）。治疗8周后试验组总有效率明显优于对照组。安全性方面两组比较无差异。 结论 盐酸氨基葡萄糖结合塞来昔布治疗KOA，能明显改善患者的临床症状，疗效优于单纯的塞来昔布治疗，且不会增加药物不良反应，具有较好的临床价值。