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find Keyword "黄斑变性" 205 results
  • Current progress on the study of microparticles in ocular fundus diseases

    Microparticles are small vesicles that are released by budding of the plasma membrane during cellular activation and apoptotic cell breakdown. A spectrum of cell types can release microparticles including endothelial cells, platelets, macrophages, lymphocytes and tumor cells. Biological effects of microparticles mainly include procoagulant activity, inhibition of inflammation and cancer progression. The present study shows that vitreous microparticles isolated from proliferative diabetic retinopathy (PDR) stimulated endothelial cell proliferation and increased new vessel formation, promoting the pathological neovascularization in PDR patients. Oxidative stress induces the formation of retina pigment epithelium-derived microparticles carrying membrane complement regulatory proteins, which is associated with drusen formation and age related macular degeneration. Microparticles from lymphocyte (LMP) play an important role in anti-angiogenesis by altering the gene expression pattern of angiogenesis-related factors in macrophages. Besides, LMP are important proapoptotic regulators for retinoblastoma cells through reduction of spleen tyrosine kinase expression and upregulation of the p53-p21 pathway which ultimately activates caspase-3. However, how to apply the microparticles in the prevention and treatment of retinal diseases is a major challenge, because the study of the microparticles in the fundus diseases is still limited. Further studies conducted would certainly enhance the application of microparticles in the fundus diseases.

    Release date:2018-03-16 02:36 Export PDF Favorites Scan
  • Exploration of the relations of diabetic retinopathy and maculopathy

    Purpose To clarify the relationship between diabetic retinopathy (DR) and maculopathy (DM) and explore the clinical implication of independent graduation of DM. Methods Fundus fluorescein angiography and routine ophthalmological examination were performed on 582 cases of diabetes.Their ocular fundi and macular impairments were graded. Results In general,the severity of diabetic macular impairment was accompanied by retinal involvement,but discrepancy existed between DM and DR.Degree I DM occurred in 5.4% (16/294) among cases without DR,in stage IV DR,degree Ⅲ DM accounted for the most part ,54.5% (116/213).There were still 5.1% (2/39) cases without DM in stage Ⅴ DR. Conclusion The degree of the macular lesions in DM is often not in parallel with the gradation of general affections in retinal tissue other than in macular region in DR,therefore,independentg radation of diabetic maculopathy has its clinical significance for choosing the optimal period of treating maculopathy and preserving the macular function. (Chin J Ocul Fundus Dis,2000,16:153-154)

    Release date:2016-09-02 06:05 Export PDF Favorites Scan
  • 老年黄斑变性患者的血液流变学改变

    本文报告23例老年黄斑变性(AMD)患者的血液流变学改变。结果血沉、血沉方程K值、血浆比粘度明显升高;红细胞电泳率明显加快;红细胞压积、全血比粘度、高切变率下的全血还原比粘度明显降低;红细胞聚集指数、低切变下全血还原比粘度无明显改变。AMD的血液流变学特点:⑴呈血液高粘滞综合征;⑵血浆成份及比例可能异常;⑶明显的低比容状态;⑷红细胞变性能力和聚集性正常。 (中华眼底病杂志,1993,9:27-28)

    Release date:2016-09-02 06:35 Export PDF Favorites Scan
  • 渗出型老年性黄斑变性玻璃体积血的追踪观察

    Release date:2016-09-02 06:01 Export PDF Favorites Scan
  • 光动力疗法治疗视网膜血管瘤样增生初步报告

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • 重复光动力疗法治疗脉络膜新生血管的疗效观察

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • 补体在渗出型老年性黄斑变性中的作用研究进展

    补体系统是机体免疫系统的重要组成部分,广泛参与机体抗微生物防御反应,清除凋亡细胞和免疫复合物以及维持组织稳态,进行免疫调节。补体系统与老年性黄斑变性(AMD)发生也密切相关。在玻璃膜疣中,含有多种选择激活途径中的蛋白;补体成分基因变异也使AMD的发病风险大大增加。补体系统多种分子与AMD CNV形成关系密切,针对补体系统异常激活的治疗可能为渗出型AMD的治疗带来新的曙光。

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • 玻璃体手术治疗老年性黄斑变性玻璃体积血

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • 影响抗血管内皮生成因子治疗渗出型老年性黄斑变性预后的因素

    玻璃体腔注射抗血管内皮生长因子(VEGF)药物是治疗渗出型老年性黄斑变性(AMD)脉络膜新生血管(CNV)的安全有效方法 。但基线视力、年龄、首发症状、开始治疗的时间、对最初3次治疗的反应以及光相干断层扫描、荧光素眼底血管造影、眼底自身荧光检查结果不同的患者,其治疗预后差异较大;除了上述临床特征和指标外,基因及生物学标记物方面的差异对治疗预后也有影响。探讨影响渗出型AMD患者抗VEGF治疗预后众多相关因素中的主要因素并采取相应的对策,对于提升抗VEGF药物治疗效果具有积极意义。

    Release date:2016-09-02 05:22 Export PDF Favorites Scan
  • 老年性黄斑变性的视觉电生理检测

    视觉电生理检查是一种客观的定性的视功能检查法,在老年性黄斑变性(AMD)的早期诊断、病情监测、疗效判定、预后评估中有较好的应用价值。在常规电生理检测方法中, 局部视网膜电图(L-ERG)是较理想的视功能测定法,图形视网膜电图(P-ERG)、图形视 觉诱发电位(P-VEP)也有一定的应用价值。振荡电位可能是新的敏感指标。多焦电生理检测作为新的视功能测定方法,可对AMD患者病变部位的视功能进行定量检测,先于形态学的改 变发现AMD的视功能异常,是AMD早期诊断、病情监测、预后及疗效判断的有价值工具。 (中华眼底病杂志,2004,20:328-330)

    Release date:2016-09-02 05:58 Export PDF Favorites Scan
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