ObjectiveTo identify factors and strategies for the sustainability of evidence-based health promotion programs. MethodsThe articles related to program sustainability factors and strategies were retrieved from the CNKI, WanFang Data, VIP, PubMed, and Web of Science database. The search period for English literature was from June 19, 2018, to December 3, 2024, while no start date was set for Chinese literature, with the same end date. Three researchers independently screened studies based on predefined inclusion and exclusion criteria and subsequently extracted the basic characteristics from the included studies. Thematic analysis was conducted to identify the sustainability factors and strategies from the included studies. ResultsA total of 65 articles were included in the scoping review. Through thematic analysis, 23 factors were identified and classified into six categories: program characteristics, organization characteristics, human resources, material resources, community resources and policy resources, along with 44 strategies grouped into six categories: programming strategies, collaborative strategies, capacity-building strategies, resource mobilization strategies, communication and dissemination strategies, and evaluative strategies. ConclusionThe sustainability factors and strategies identified in this study exhibit conceptual and structural alignment with existing frameworks and strategy sets in implementation science. Concurrently, by incorporating a full life-cycle perspective, this study delineates context-specific factors and strategies tailored to the unique requirements of sustaining programs over time, thereby contributing to a more nuanced understanding of program sustainability and offering practical guidance for strengthening the longevity of evidence-based health promotion programs.