Objective To assess the efficacy and safety of gabapentin for restless legs syndrome (RLS). Methods Such databases as PubMed, EMbase, CENTRAL and CBM were searched for collecting the randomized controlled trials (RCTs) on the efficacy and/or tolerability of gabapentin for restless legs syndrome. Methodological quality of the trials was evaluated using the Cochrane risk-of-bias criteria, and meta-analysis was carried out using RevMan 5.1. Results Seven RCTs involving 1 163 patients which met the criteria were included, of which 4 were placebo parallel controlled trials and 3 were placebo cross-over trials. The outcomes of meta-analysis suggested that a) As to the change of RLS severity based on IRLSSG score, gabapentin was superior to placebo in alleviating the severity of RLS (MD= –3.24, 95%CI –4.40 to –2.09, Plt;0.000 01); b) As to the response rate based on investigator-rated CGI-I scale, it was higher in the gabapentin group (77%) compared with that in the placebo group (50%) (RR=1.81, 95%CI 1.54 to 2.11, Plt;0.000 01); c) As to quality of sleep, gabapentin was superior to placebo in reducing sleep disturbance (MD= –11.31, 95%CI –14.46 to –8.16), assuring quality of sleep (MD= 0.27, 95%CI 0.10 to 0.44) and alleviating daytime somnolence (MD= –3.96, 95%CI –6.42 to –1.50); and d) As to the RLS pain score, gabapentin was better in relieving pain compared with placebo (MD= –0.97, 95%CI –1.47 to –0.47). In addition, main side effects were somnolence (3.1% to 26.5%) and dizziness (2.1% to 19.5%), and there was a significant difference between two groups. Conclusion Gabapentin can effectively alleviate RLS patients’ condition, improve quality of sleep, relieve pain and show good tolerability.
Objective To analyze the current state, evaluate the accuracy, and determine the influencing factors of diabetes-related subscriptions on the WeChat platform. Methods The top 100 WeChat platforms on the "China WeChat Platform New Rank Annual List 2020" were searched using the term "diabetes". We identified diabetes-related subscriptions published from June 1, 2021 to August 31, 2021. The accuracy of subscriptions was analyzed according to the consistency with clinical practice guidelines, and was independently assessed by two specialists. SPSS 22.0 software was used for data analysis. Results Sixty-eight subscriptions from 26 WeChat platforms were included. Twenty-five (36.8%) subscriptions were evaluated as inconsistent. The numbers of "wow" per thousand reads and "like" per thousand reads of inconsistent diabetic subscriptions were statistically higher than those of consistent diabetic subscriptions (P<0.05). Subscriptions with expert support (80.8% vs. 52.4%) and evidence support (91.7% vs. 57.1%) shared a higher consistency (P<0.05). Subscriptions with commercial promotion (16.7% vs. 67.7%) had a lower consistency (P=0.02). Conclusion Although some content is inconsistent with guidelines, diabetes-related subscriptions have a certain dissemination ability on the WeChat platform. Moreover, readers are more likely to "wow" or "like" for inconsistent subscriptions. Diabetes-related subscriptions on the WeChat public platform need supervision and can be further regulated by providing evidence support and regulating commercial promotion.
ObjectiveThe aim of this study was to investigate the changes in peripheral blood metabolites and transcriptomes in patients with obstructive sleep apnea (OSA) and to assess their diagnostic value as biomarkers. MethodsIn this study, we utilized liquid chromatography-tandem mass spectrometry (LC-MS/MS) lipid-targeted metabolomics to compare the metabolic profiles of 30 OSA patients with those of 30 healthy controls, identifying differential lipid metabolites. Through Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, we determined that the glycerolipid metabolism pathway was significantly different. Furthermore, we conducted transcriptome analysis on peripheral blood mononuclear cells (PBMCs) from six OSA patients and six healthy controls to evaluate the expression of molecules related to the pathway. ResultsA total of 168 differential lipid metabolites were identified, with significant differences in the glycerolipid metabolism pathway between OSA patients and healthy controls. Transcriptome analysis revealed that glycerolipid metabolism-related molecules GPAT, AGPAT, and LPIN were under expressed in OSA patient PBMCs, suggesting that the glycerolipid metabolism pathway is suppressed in OSA patients. Additionally, diagnostic value analysis showed that GPAT and AGPAT had high AUC values, indicating their potential as biomarkers for OSA. ConclusionThe suppression of the glycerolipid metabolism pathway is closely related to the development of OSA, and the under expression of key genes in this pathway, such as GPAT, AGPAT, and LPIN, may be involved in the pathophysiological process of OSA. These findings not only provide a new perspective for understanding the pathogenesis of OSA but also offer new scientific evidence for the treatment of OSA from the perspective of glycerolipid metabolism regulation.
Objective To study the differences of obstructive sleep apnea hypopnea syndrome (OSAHS)-related indexes between Uyghur and Han, and to provide evidence for the development of individualized treatment measures for different ethnic groups. Methods 224 Han OSAHS patients were collected from Guangdong Provincial Hospital of Chinese Medicine, and 178 Uygur OSAHS patients were collected from The First People’s Hospital of Kashi between January 2018 and December 2019. The collected data information included age, sex, nationality, body mass index (BMI), apnea hypopnea index (AHI), lowest oxygen saturation (LSaO2), OSAHS stage, mean corpuscular hemoglobin concentration (MCHC), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting blood glucose (FBG), and glycosylated hemoglobin (HbAlc). After using propensity matching scores to reduce confounding factors, differences in above indicators between different nationalities were compared. Results The mean values of MCHC, TC and HDL in Uygur OSAHS patients were lower than those in Han patients at the same stage, and the mean values of LSaO2 and LDL in mild and severe Uygur OSAHS patients were lower than those in Han patients at the same stage, with statistically significant differences (all P<0.05). There were no significant differences in AHI, TG, FBG or HbAlc between Uygur and Han patients with OSAHS. Conclusion There are significant differences in LSaO2, LDL, MCHC, TC and HDL between Uygur and Han Chinese patients with OSAHS.