目的 探讨环氧化酶-2（COX-2）在幽门螺杆菌（Hp）感染与非感染性胃溃疡及胃癌的表达。 方法 选择绵阳市404医院消化内科2011年2月－2012年2月的门诊及住院患者，用免疫组织化学方法检测196例经胃镜和组织病理学检查明确为胃溃疡（病理分型：肠上皮化生、异型增生）、胃癌及正常胃黏膜者的胃黏膜COX-2蛋白的表达，比较各病理分类之间及Hp感染与非感染之间COX-2蛋白表达的差异。 结果 胃溃疡（肠上皮化生、异型增生）、胃癌组的炎症细胞、腺上皮细胞、癌细胞及极少量正常黏膜上皮细胞中有COX-2表达。从正常胃黏膜-胃溃疡（肠上皮化生、异型增生）-胃癌COX-2的阳性表达有逐渐增强的趋势（P＜0.05）。Hp阳性组COX-2的阳性表达高于Hp阴性组（P＜0.05），胃癌组COX-2的阳性表达高于胃溃疡组（P＜0．05）。 结论 COX-2在胃癌的表达高于胃溃疡。Hp感染可诱导COX-2过度表达。
Objective To analyze the application research of prehabilitation in patients with lumbar degenerative spine surgery, and to review the intervention content, outcome index, and applied effect of prehabilitation of lumbar spine surgery patients, to provide references for the future clinical development of related research. Methods Guided by the methodology of scope review, systematic searches were conducted on China National Knowledge Infrastructure, Wanfang Database, VIP, China Biomedical Literature Database, PubMed, Embase, CINAHL, Web of Science, and Cochrane Library databases from the establishment of the database to June 2024, and the included literature was screened, refined and summarized. Results A total of 21 papers were included, including 15 randomized controlled trials, 5 quasi-experimental studies, and 1 retrospective study. The main components of prehabilitation included exercise, preoperative psychological support, nutritional interventions, and multiform health education; and the main outcome indicators included pain, assessment of low back function, sleep quality, anxiety and depression, and healthy quality of life.Conclusion Preoperative prehabilitation has a positive effect on patients undergoing surgery for lumbar degenerative disease, and the existing studies are heterogeneous in terms of content and outcome indicators, and the follow-up should continue to construct a more scientific and multimodal intervention program and carry out large-scale high-quality studies.