Objective To analyze and summarize the research progression of phenotypic markers of hepatic sinusoidal endothelial cell （HSEC） and its role in the development and progression of the liver diseases. Methods Databases such as PubMed， Wanfang， CNKI， etc were retrieved for the latest articles on research advance in HSEC using “hepatic sinus endothelial cell”， “liver regeneration”， and “liver disease” as key words. All of the publications about studies on relation between HSEC and liver disease were reviewed and summarized. Results HSEC with specific cytoarchitectures and phenotypic markers was initially received “the message of damage” in the process of liver regeneration， hepatic immunological tolerance， hepatic fibrosis， and liver damage. Additionally， HSEC as the first barrier not only enabled liver to be protected but also was regarded as the first alternation of liver damage. Therefore， HSEC played a great important role in the process of the onset and progression of the liver disease. Conclusions The function of HSEC is complex. How do play a role and its the mechanism is unclarified， it is needed to be further studied.
ObjectiveTo investigate the optimal treatment scheme for the first primary spontaneous pneumothorax (PSP) in young patients.MethodsThe clinical data of 171 patients with the first PSP were retrospectively analyzed who were treated in Huaihe Hospital of Henan University between November 2011 and October 2017. There were 157 males and 14 females with a median age of 18 years at onset and a median body mass index of 18.51 kg/m2. According to the treatment methods, they were classified into two groups, a conservative treatment group (a non-surgical group, n=86) and a surgical group (n=85). The characteristics including clinical data, efficacy evaluation criteria, complications and recurrence of the two groups were analyzed.ResultsAs a result, 73.68% of the patients suffered PSP in their daily routine. The drainage duration in the non-surgical group was longer than that in the surgical group (4 d vs. 3 d, P=0.008). There was no statistical difference in the success rate of lung re-expansion between the two groups (98.85% vs. 100.00%, P=1.000). The proportion of the surgical group using postoperative analgesic drugs was higher than that in the non-surgical group (48.23% vs. 10.46%, P=0.000). The recurrence rate of the surgical group was lower than that of the non-surgical group (3.53% vs. 46.51%, P=0.000). No relationship between smoking and recurrence of pneumothorax was found in both groups (P=0.301, P=1.000). The success rate of lung re-expansion in the non-surgical group was not statistically different between the 24F subgroup and the 12F subgroup (39/39 vs. 33/34, P=0.458). No advantage of intraoperative pleural fixation was found in the surgical group (P=0.693).ConclusionThoracoscopic surgery is the first choice for the treatment of the first PSP in young patients.
ObjectiveTo explore the effects of Baduanjin combined with breathing exercises and bedside cycle training on the recovery of lung function in patients after thoracoscopic surgery for lung cancer. MethodsPatients who underwent thoracoscopic radical surgery for lung cancer at the Huaihe Hospital of Henan University from January 2024 to January 2025 were selected. Through the random number table method, patients were randomly divided into a Baduanjin combined with breathing exercises group (experimental group) and a bedside cycle group (control group). The changes in lung function indicators, pain levels, exercise endurance, cellular immunity, and inflammatory factor levels before and after rehabilitation training in both groups were compared to evaluate the clinical effects of the two rehabilitation methods. ResultsA total of 100 patients were included, with 52 in the experimental group, including 28 males and 24 females, with an average age of (57.50±7.15) years; and 48 in the control group, including 26 males and 22 females, with an average age of (57.80±6.40) years. There was no statistical difference in baseline data between the two groups (P＞0.05). In the experimental group, the forced expiratory volume in one second (FEV1) [(2.48±0.32) L vs. (2.00±0.27) L, P＜0.001], forced vital capacity (FVC) [(3.55±0.42) L vs. (2.95±0.34) L, P＜0.001], and FEV1/FVC (69.9%±3.8% vs. 67.8%±3.6%, P=0.006) were higher, pain scores were lower [(1.4±0.4) points vs. (2.0±0.5) points, P＜0.001], 6-minute walking distance was longer [(432.35±30.84) m vs. (411.82±33.75) m, P=0.002], CD4+/CD8+ ratio was higher (1.72±0.32 vs. 1.52±0.29, P=0.002), and levels of tumor necrosis factor-α [(8.1±1.8) pg/mL vs. (9.2±2.1) pg/mL, P=0.006] and interleukin-6 [(8.3±2.1) ng/L vs. (10.1±2.7) ng/L, P＜0.001] were lower. ConclusionThe combination of Baduanjin and breathing exercises is superior to bedside stationary bike training in improving lung function, reducing pain levels, enhancing exercise endurance, decreasing pro-inflammatory factor levels, and boosting immune function in patients post-thoracotomy for lung cancer. As a equipment-free, low-cost, and easy-to-implement rehabilitation method, it holds high clinical application value, offering a more scientific and economical option for postoperative lung cancer patients' pulmonary rehabilitation.