• Department of Thyroid and Breast Surgery, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu 225001, P.R.China;
FU Deyuan, Email: fdy1003@163.com
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Objective To explore advances in clinical applications of circulating tumor DNA (ctDNA) for early diagnosis of breast cancer.Method Reviewed on the latest literatures about studies of advances in clinical applications of ctDNA for early diagnosis of breast cancer.Results ctDNA was a cell-free DNA generated by tumor cells that contained tumor-associated mutations and could dynamically reflect the entire picture of the tumor genome. It was a very important potential tumor biomarker. ctDNA had been widely used in a variety of tumors for early diagnosis, curative effect assessment, and prognosis evaluation due to its advantages such as small trauma and real-time monitoring, and its role in breast cancer had attracted more and more attention.Conclusion Early diagnosis is critical to improve the breast cancer patients’ overall survival rate and ctDNA plays an important role in early diagnosis and early detection of recurrence and metastasis of breast cancer.

Citation: TANG Lei, FU Deyuan. Advances in clinical applications of circulating tumor DNA for early diagnosis of breast cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(8): 1086-1090. doi: 10.7507/1007-9424.202011048 Copy

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