• Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P. R. China;
DU Chengyou, Email: duchengyou@126.com
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Objective To summarize the research progress of hepatocellular carcinoma (HCC) based on tumor microenvironment immunophenotyping.Method The related literatures of basic and clinical studies on HCC immunophenotyping in the recent years were reviewed.Results HCC could be divided into different immunophenotypes based on tumor microenvironment, and it showed different immune molecular characteristics, immune cell infiltration characteristics, and anti-tumor ability. At the same time, the HCC immunophenotype was significantly associated with patients’ survival and had been proved to be able to better evaluate the prognosis of HCC patients. According to the relevant molecular characteristics in the HCC immune microenvironment, it could provide guidance for the drug regimen of immunotherapy.Conclusion HCC immunophenotyping is still in the early stage of research, and its clinical application value has been preliminarily shown for the evaluation of patients’ prognosis and immunotherapy decision-making, which is a new idea of individualized treatment of HCC in the future.

Citation: LIU Jiarui, XIAO Heng, DU Chengyou. Advances in immunophenotyping of hepatocellular carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(9): 1237-1242. doi: 10.7507/1007-9424.202011062 Copy

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